Published in Hum Mol Genet on January 06, 2006
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Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell (2007) 5.91
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol (2006) 5.70
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science (2006) 5.31
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Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity (2009) 5.10
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
PI3 kinase signals BCR-dependent mature B cell survival. Cell (2009) 4.43
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell (2004) 4.31
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. N Engl J Med (2014) 4.00
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity (2006) 3.74
Differential roles of macrophages in diverse phases of skin repair. J Immunol (2010) 3.56
Vagaries of conditional gene targeting. Nat Immunol (2007) 3.51
Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol (2007) 3.51
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol (2006) 3.39
Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell (2013) 3.34
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet (2007) 3.30
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature (2011) 3.17
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell (2012) 3.10
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity (2011) 3.10
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
Yin Yang 1 is a critical regulator of B-cell development. Genes Dev (2007) 3.06
B cell receptor signal strength determines B cell fate. Nat Immunol (2004) 3.06
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc Natl Acad Sci U S A (2002) 3.01
Potential risks of bone marrow cell transplantation into infarcted hearts. Blood (2007) 2.97
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J (2003) 2.94
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol (2004) 2.94
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Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77
BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. Cancer Cell (2010) 2.73
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.66
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol (2003) 2.65
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med (2012) 2.59
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med (2004) 2.58
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol (2004) 2.51
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol (2006) 2.48
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A (2004) 2.46
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet (2002) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44