Published in EMBO J on May 01, 2003
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell (2008) 7.61
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res (2012) 3.74
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev (2006) 3.31
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev (2012) 2.82
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol Oncol (2011) 2.52
Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab (2008) 2.47
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol (2007) 2.22
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci U S A (2004) 2.20
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells. Nucleic Acids Res (2007) 2.08
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J (2006) 1.97
Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Proc Natl Acad Sci U S A (2003) 1.85
Parthanatos, a messenger of death. Front Biosci (Landmark Ed) (2009) 1.84
Repair Pathway Choices and Consequences at the Double-Strand Break. Trends Cell Biol (2015) 1.84
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol (2007) 1.75
Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab (2014) 1.72
The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series. EMBO Rep (2008) 1.69
Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Mol Aspects Med (2013) 1.62
CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery. J Biol Chem (2008) 1.62
PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab (2011) 1.55
Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. PLoS Genet (2015) 1.53
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem (2008) 1.45
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination. J Exp Med (2009) 1.44
Histone variants in metazoan development. Dev Cell (2010) 1.42
The roles of PARP1 in gene control and cell differentiation. Curr Opin Genet Dev (2010) 1.40
Chromatin remodeling in cardiovascular development and physiology. Circ Res (2011) 1.34
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment. Mol Psychiatry (2013) 1.30
Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res (2009) 1.30
Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2. Mol Cell Biol (2004) 1.27
Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death. Biochem J (2006) 1.27
PARP-1 and PARP-2: New players in tumour development. Am J Cancer Res (2011) 1.23
A systematic analysis of the PARP protein family identifies new functions critical for cell physiology. Nat Commun (2013) 1.19
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes. EMBO J (2006) 1.18
DNA repair proteins as molecular targets for cancer therapeutics. Anticancer Agents Med Chem (2008) 1.17
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood (2013) 1.16
Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry. Proteome Sci (2010) 1.14
Poly(ADP-ribosyl)ation in mammalian ageing. Nucleic Acids Res (2007) 1.13
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A (2006) 1.13
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Res (2004) 1.12
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS One (2010) 1.10
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein. Nucleic Acids Res (2004) 1.09
PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. J Biol Chem (2009) 1.08
ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation. Cell Commun Signal (2013) 1.08
PARP inhibitor treatment in ovarian and breast cancer. Curr Probl Cancer (2011) 1.08
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood (2009) 1.08
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc Natl Acad Sci U S A (2005) 1.05
PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks. J Cell Biol (2011) 1.02
Targeting abnormal DNA double strand break repair in cancer. Cell Mol Life Sci (2010) 1.01
Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. Genetics (2006) 1.00
SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency. Proc Natl Acad Sci U S A (2012) 0.99
PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1. Nucleic Acids Res (2014) 0.98
Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. Cancer J (2010) 0.98
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. Chromosoma (2013) 0.98
Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma (2005) 0.97
Base excision repair, aging and health span. Mech Ageing Dev (2008) 0.97
Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol Cell Biol (2004) 0.97
Targeting poly(ADP-ribose) polymerase activity for cancer therapy. Cell Mol Life Sci (2010) 0.96
Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles. PLoS One (2012) 0.95
The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. Am J Cancer Res (2010) 0.95
Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair. Antioxid Redox Signal (2013) 0.95
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod (2011) 0.93
Telomere biology: integrating chromosomal end protection with DNA damage response. Chromosoma (2005) 0.92
Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life. DNA Repair (Amst) (2014) 0.92
The role of ADP-ribosylation in regulating DNA double-strand break repair. Cell Cycle (2012) 0.91
Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair. Nucleic Acids Res (2014) 0.91
Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation. Oxid Med Cell Longev (2012) 0.90
PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses. PLoS Genet (2015) 0.90
Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod (2009) 0.90
PARP is involved in replicative aging in Neurospora crassa. Fungal Genet Biol (2010) 0.90
Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway. Stem Cells (2011) 0.89
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. Chem Rev (2015) 0.88
PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. J Biol Chem (2009) 0.87
Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res (2015) 0.87
Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development. BMC Mol Biol (2004) 0.87
MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs (2011) 0.87
The BRCT domain of PARP-1 is required for immunoglobulin gene conversion. PLoS Biol (2010) 0.86
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease. Reproduction (2011) 0.86
Metabolic modulation of chromatin: implications for DNA repair and genomic integrity. Front Genet (2013) 0.85
Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions. J Biol Chem (2014) 0.85
Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation. Br J Pharmacol (2009) 0.85
Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer. Invest New Drugs (2014) 0.85
Interference between PARPs and SIRT1: a novel approach to healthy ageing? Aging (Albany NY) (2011) 0.85
DNA ligases as therapeutic targets. Transl Cancer Res (2013) 0.85
Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes. Dev Biol (2009) 0.84
Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation. J Neurochem (2008) 0.84
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. J Neurochem (2010) 0.84
Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma (2013) 0.84
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death Differ (2014) 0.83
Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis. Int J Mol Sci (2015) 0.83
Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes (2013) 0.82
The chromatin remodeling factor Chd1l is required in the preimplantation embryo. Biol Open (2012) 0.82
Development of synthetic lethality anticancer therapeutics. J Med Chem (2014) 0.82
Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP‑ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells. Int J Oncol (2012) 0.81
Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. J Virol (2012) 0.81
Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase. Mol Cell Biol (2014) 0.81
The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev (2002) 5.92
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
Segregating sister genomes: the molecular biology of chromosome separation. Science (2002) 4.92
Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol Cell Biol (1999) 4.20
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem (2002) 3.92
X-chromosome inactivation: counting, choice and initiation. Nat Rev Genet (2001) 3.75
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A (1996) 3.34
A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24
PARP is important for genomic stability but dispensable in apoptosis. Genes Dev (1997) 3.20
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem (1999) 2.92
Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry (2000) 2.84
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci (1998) 2.78
Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev Biol (1999) 2.64
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DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. Nucleic Acids Res (1998) 2.21
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene. Nucleic Acids Res (2001) 1.96
MACROH2A2, a new member of the MARCOH2A core histone family. J Biol Chem (2001) 1.86
A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability. Nat Genet (2000) 1.80
Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem (1998) 1.79
A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity. Mutat Res (1998) 1.74
Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat Genet (1997) 1.71
Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Annu Rev Biochem (2001) 1.55
Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development. Genes Dev (2000) 1.48
The response of Parp knockout mice against DNA damaging agents. Mutat Res (2000) 1.34
Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated. J Biol Chem (2002) 1.27
A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene. J Biol Chem (2000) 1.24
Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc. Hum Mol Genet (2002) 1.17
Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase. Hum Mol Genet (2000) 1.15
A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets. Cytogenet Cell Genet (1977) 1.08
DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53. Mol Cell Biol (2000) 1.07
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Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2. J Biol Chem (2002) 1.02
Accelerated telomere shortening in the human inactive X chromosome. Am J Hum Genet (1999) 0.99
Female embryonic lethality in Msh2-Trp53 nullizygous mice is strain dependent. Mamm Genome (1999) 0.89
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med (2006) 10.48
Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol (2006) 9.58
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
The PARP superfamily. Bioessays (2004) 6.14
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem (2002) 3.92
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol (2006) 3.39
Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell (2013) 3.34
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell (2004) 3.32
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol (2003) 2.65
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med (2012) 2.59
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation. Mol Cell (2009) 2.56
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A (2004) 2.46
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet (2002) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology (2007) 2.40
The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol (2002) 2.40
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab (2006) 2.26
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol (2002) 2.25
International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22
Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell (2011) 2.22
Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis (2008) 2.21
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol (2005) 2.13
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A (2011) 2.10
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells. Nucleic Acids Res (2007) 2.08
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A (2003) 2.07
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A (2005) 2.07
State of the art in research into the risk of low dose radiation exposure--findings of the fourth MELODI workshop. J Radiol Prot (2013) 2.06
Function of retinoic acid receptors during embryonic development. Nucl Recept Signal (2009) 2.06
Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res (2002) 2.05
International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev (2006) 2.04
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J (2006) 1.97
Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A (2006) 1.95
Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proc Natl Acad Sci U S A (2008) 1.94
Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A (2005) 1.92
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art. Biochem Pharmacol (2012) 1.89
Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci (2009) 1.89
Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci U S A (2003) 1.87
Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci (2003) 1.84
Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development (2005) 1.83
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice. J Clin Invest (2011) 1.81
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep (2002) 1.79
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76
Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis. Endocrinology (2005) 1.76
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. Genes Dev (2004) 1.76
PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli. J Cell Sci (2005) 1.73
RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J Exp Med (2006) 1.72
Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci U S A (2003) 1.72
Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun (2011) 1.69
Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation. Arterioscler Thromb Vasc Biol (2008) 1.69
The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series. EMBO Rep (2008) 1.69
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet (2007) 1.68
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A (2013) 1.67
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1. J Biol Chem (2003) 1.67
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev (2002) 1.67
Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science (2005) 1.66
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc Natl Acad Sci U S A (2009) 1.63
T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. J Biol Chem (2003) 1.62
Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis (2004) 1.61
Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev (2006) 1.60
Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. J Cell Sci (2002) 1.59
Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair. Methods Enzymol (2006) 1.59
Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest (2003) 1.59
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development. DNA Repair (Amst) (2004) 1.58
Human telomerase reverse transcriptase (hTERT) and Ki-67 are better predictors of survival than established clinical indicators in patients undergoing curative hepatic resection for colorectal metastases. Ann Surg Oncol (2004) 1.58