Published in Development on April 21, 2004
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40
Scratching the surface of skin development. Nature (2007) 4.61
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16
Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res (2004) 2.91
Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A (2006) 2.72
Skin stem cells: rising to the surface. J Cell Biol (2008) 2.66
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development (2012) 2.01
Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell (2012) 1.99
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol (2009) 1.73
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol (2009) 1.65
Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell (2008) 1.61
Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation. Dev Biol (2006) 1.54
Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A (2013) 1.52
Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol (2006) 1.50
Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling. Semin Cell Dev Biol (2012) 1.41
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev (2005) 1.38
Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development (2009) 1.37
Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities. J Immunol (2008) 1.37
Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proc Natl Acad Sci U S A (2006) 1.35
FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development (2009) 1.35
Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. Dev Cell (2012) 1.34
Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol (2010) 1.34
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
What does the concept of the stem cell niche really mean today? BMC Biol (2012) 1.32
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32
Fate of HERS during tooth root development. Dev Biol (2009) 1.31
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol (2006) 1.28
Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One (2010) 1.25
Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res (2010) 1.24
Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol (2012) 1.22
Current knowledge of tooth development: patterning and mineralization of the murine dentition. J Anat (2009) 1.21
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis. Proc Natl Acad Sci U S A (2012) 1.19
Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function. Mol Biol Cell (2007) 1.16
Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling. Mol Biol Cell (2007) 1.14
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet (2010) 1.13
Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression. Dev Biol (2010) 1.12
BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol (2010) 1.12
Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12
Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery. Gene Ther (2007) 1.12
Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol (2013) 1.11
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (2012) 1.11
Evolved tooth gain in sticklebacks is associated with a cis-regulatory allele of Bmp6. Proc Natl Acad Sci U S A (2014) 1.06
Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity. Int J Dev Biol (2009) 1.05
Molecular patterning of the mammalian dentition. Semin Cell Dev Biol (2013) 1.05
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation. Dev Biol (2008) 1.04
Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development (2013) 1.04
The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development (2013) 1.04
Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Am J Pathol (2009) 1.04
Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. PLoS Genet (2009) 1.04
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem (2009) 1.04
Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell (2014) 1.04
Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS One (2010) 1.03
Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J Exp Zool B Mol Dev Evol (2009) 1.02
MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes. J Cell Sci (2011) 1.01
A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet (2013) 1.00
BMP signaling and its pSMAD1/5 target genes differentially regulate hair follicle stem cell lineages. Cell Stem Cell (2014) 0.98
Tissue interaction is required for glenoid fossa development during temporomandibular joint formation. Dev Dyn (2011) 0.98
Signaling involved in hair follicle morphogenesis and development. Int J Mol Sci (2014) 0.97
Stem cells and female reproduction. Reprod Sci (2009) 0.96
Disruption of Smad4 in mouse epidermis leads to depletion of follicle stem cells. Mol Biol Cell (2008) 0.94
Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol (2011) 0.94
Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol (2012) 0.93
Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci (2010) 0.93
BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts. J Invest Dermatol (2009) 0.93
From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol (2012) 0.92
Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem (2013) 0.90
Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene (2014) 0.90
Stem Cell Fate Determination during Development and Regeneration of Ectodermal Organs. Front Physiol (2012) 0.89
miR-24 affects hair follicle morphogenesis targeting Tcf-3. Cell Death Dis (2013) 0.89
Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev Biol (2008) 0.89
Developmental stalling and organ-autonomous regulation of morphogenesis. Proc Natl Acad Sci U S A (2011) 0.89
Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol (2013) 0.89
BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell (2015) 0.89
BMP activity is required for tooth development from the lamina to bud stage. J Dent Res (2012) 0.87
Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn (2011) 0.86
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife (2015) 0.86
The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development. Development (2014) 0.86
Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development. Dev Biol (2014) 0.86
Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state. Stem Cells (2014) 0.85
Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a β-catenin-dependent manner. Mol Cell Biol (2013) 0.85
BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin. PLoS Genet (2014) 0.84
Development and homeostasis of the skin epidermis. Cold Spring Harb Perspect Biol (2012) 0.84
Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PLoS One (2013) 0.84
An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud. PLoS One (2012) 0.84
An ideal society? Neighbors of diverse origins interact to create and maintain complex mini-organs in the skin. PLoS Biol (2005) 0.84
A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia. J Clin Invest (2014) 0.84
Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development. Development (2013) 0.83
Noggin is required for early development of murine upper incisors. J Dent Res (2012) 0.83
Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17
Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A (2003) 7.87
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med (2008) 4.20
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol (2008) 4.07
Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. N Engl J Med (2014) 4.00
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (2003) 3.49
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol (2006) 3.39
Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell (2013) 3.34
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. Proc Natl Acad Sci U S A (2006) 3.32
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity (2008) 3.25
Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem (2004) 3.21
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A (2002) 2.99
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J (2003) 2.94
Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation (2007) 2.93
beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev Biol (2003) 2.85
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A (2005) 2.82
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77
Requirement of Bmpr1a for Müllerian duct regression during male sexual development. Nat Genet (2002) 2.75
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature (2013) 2.70
Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem (2004) 2.70
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol (2003) 2.65
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A (2006) 2.60
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med (2012) 2.59
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Distinct functions for Bmp signaling in lip and palate fusion in mice. Development (2005) 2.46
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A (2004) 2.46
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet (2002) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet (2006) 2.43
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Autoregulation of neurogenesis by GDF11. Neuron (2003) 2.40
Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology (2007) 2.40
The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol (2002) 2.40
Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists. Nat Med (2011) 2.40
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab (2007) 2.39
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab (2006) 2.26
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A (2004) 2.25
BMP signaling and early embryonic patterning. Cytokine Growth Factor Rev (2005) 2.25
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development (2004) 2.24
International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22
Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell (2011) 2.22
Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis (2008) 2.21
BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology (2006) 2.21
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature (2007) 2.21
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol (2005) 2.13
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells (2006) 2.09
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A (2003) 2.07
Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage. Gastroenterology (2007) 2.07
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A (2005) 2.07
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med (2005) 2.06
Function of retinoic acid receptors during embryonic development. Nucl Recept Signal (2009) 2.06
BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol (2004) 2.05
α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal (2011) 2.05
Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res (2002) 2.05
GDF11 controls the timing of progenitor cell competence in developing retina. Science (2005) 2.04
International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev (2006) 2.04
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest (2012) 2.01