Published in Genesis on January 01, 2006
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Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature (2012) 3.51
Clonal dynamics of native haematopoiesis. Nature (2014) 3.15
The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell (2013) 3.14
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature (2014) 2.77
FragSeq: transcriptome-wide RNA structure probing using high-throughput sequencing. Nat Methods (2010) 2.71
A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods (2009) 2.65
Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol (2014) 2.62
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol (2013) 2.53
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. Proc Natl Acad Sci U S A (2007) 2.27
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet (2012) 2.19
Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods (2009) 1.92
A pipeline for the generation of shRNA transgenic mice. Nat Protoc (2012) 1.76
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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature (2016) 1.62
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis. J Clin Invest (2016) 1.48
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. Cancer Cell (2015) 1.47
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proc Natl Acad Sci U S A (2008) 1.41
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun (2012) 1.35
Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J (2013) 1.35
The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation. Development (2010) 1.35
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nat Cell Biol (2013) 1.33
Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors. Cell Stem Cell (2012) 1.33
SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet (2013) 1.32
Silencing and un-silencing of tetracycline-controlled genes in neurons. PLoS One (2007) 1.32
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Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia (2011) 1.28
Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines. Stem Cells (2009) 1.26
Stable RNA interference rules for silencing. Nat Cell Biol (2014) 1.26
The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Mol Cell Biol (2010) 1.23
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance. Cell Stem Cell (2014) 1.23
Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proc Natl Acad Sci U S A (2011) 1.23
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development (2013) 1.19
Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med (2014) 1.17
An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol (2011) 1.17
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell Stem Cell (2014) 1.13
Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep (2012) 1.12
Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors. J Biol Chem (2012) 1.10
The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol (2011) 1.07
PTEN action in leukaemia dictated by the tissue microenvironment. Nature (2014) 1.06
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J (2014) 1.06
Specific expression of channelrhodopsin-2 in single neurons of Caenorhabditis elegans. PLoS One (2012) 1.04
Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state. Elife (2014) 1.04
In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene (2012) 1.03
Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation. Cell Stem Cell (2015) 1.00
A modular and flexible ESC-based mouse model of pancreatic cancer. Genes Dev (2014) 0.99
D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev (2014) 0.97
Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A (2015) 0.97
Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice. PLoS One (2014) 0.96
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nat Commun (2015) 0.96
Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. PLoS One (2013) 0.96
Endangered species hold clues to human evolution. J Hered (2010) 0.96
Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells. Genes Dev (2015) 0.95
Transformation of the intestinal epithelium by the MSI2 RNA-binding protein. Nat Commun (2015) 0.93
Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus. Am J Hum Genet (2012) 0.92
Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter. EMBO J (2008) 0.92
Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Stem Cells Dev (2011) 0.92
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports (2015) 0.92
Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun (2016) 0.91
Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function. Cell Rep (2012) 0.91
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med (2014) 0.91
Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1. PLoS One (2012) 0.91
Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis. Genes Dev (2014) 0.91
Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer. Proc Natl Acad Sci U S A (2015) 0.90
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res (2010) 0.90
Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models. Bioessays (2011) 0.89
A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors. Mol Cell (2016) 0.89
Transcriptional profiling of cells sorted by RNA abundance. Nat Methods (2014) 0.88
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood (2015) 0.88
Cornerstones of CRISPR-Cas in drug discovery and therapy. Nat Rev Drug Discov (2016) 0.88
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res (2014) 0.87
H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation. PLoS Genet (2013) 0.87
The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. Epigenetics Chromatin (2014) 0.87
A system for genome-wide histone variant dynamics in ES cells reveals dynamic MacroH2A2 replacement at promoters. PLoS Genet (2014) 0.86
Essentials of recombinase-based genetic fate mapping in mice. Methods Mol Biol (2014) 0.86
Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos. Mol Cell Biol (2012) 0.84
EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice. J Clin Invest (2013) 0.83
Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. J Immunol (2012) 0.83
Transgenic, inducible RNAi in megakaryocytes and platelets in mice. J Thromb Haemost (2010) 0.83
Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model. Proc Natl Acad Sci U S A (2013) 0.83
FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells. Development (2015) 0.83
A non-surgical approach for male germ cell mediated gene transmission through transgenesis. Sci Rep (2013) 0.82
The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer. Elife (2015) 0.82
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 7.57
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell (2010) 7.16
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02
A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell (2008) 5.99
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66
Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet (2002) 5.51
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell (2007) 5.29
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron (2006) 4.74
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr Biol (2008) 4.34
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell (2011) 4.29
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science (2013) 4.12
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell (2004) 3.94
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet (2009) 3.73
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell (2010) 3.70
Nuclear reprogramming and pluripotency. Nature (2006) 3.68
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell (2009) 3.42
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev (2006) 3.41