Published in Cell on April 18, 2008
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Myc's broad reach. Genes Dev (2008) 7.56
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Retracted Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature (2014) 6.57
Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol (2009) 6.39
A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell (2008) 5.99
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell (2008) 5.83
Deterministic direct reprogramming of somatic cells to pluripotency. Nature (2013) 5.18
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Elite and stochastic models for induced pluripotent stem cell generation. Nature (2009) 5.06
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
Generation of induced pluripotent stem cells from human blood. Blood (2009) 4.92
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr Biol (2008) 4.34
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood (2009) 4.22
Adult mice generated from induced pluripotent stem cells. Nature (2009) 4.21
Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A (2011) 3.93
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells (2009) 3.46
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest (2010) 3.12
Reprogramming of human peripheral blood cells to induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One (2009) 3.07
Small RNA-mediated regulation of iPS cell generation. EMBO J (2011) 2.95
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr Biol (2009) 2.89
Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet (2011) 2.81
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60
Transgenic mice with defined combinations of drug-inducible reprogramming factors. Nat Biotechnol (2009) 2.46
Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell (2014) 2.44
Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci U S A (2009) 2.44
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35
Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci (2009) 2.33
Pluripotent stem cell lines. Genes Dev (2008) 2.25
Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging. Cell Rep (2013) 2.19
Generation of induced pluripotent stem cell lines from Tibetan miniature pig. J Biol Chem (2009) 2.17
Mechanisms and models of somatic cell reprogramming. Nat Rev Genet (2013) 2.09
Overcoming reprogramming resistance of Fanconi anemia cells. Blood (2012) 2.07
Mouse differentiating spermatogonia can generate germinal stem cells in vivo. Nat Cell Biol (2008) 2.05
Differentiation therapy of leukemia: 3 decades of development. Blood (2009) 2.02
Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet (2008) 2.01
Generation of iPSCs from cultured human malignant cells. Blood (2010) 1.99
Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods (2009) 1.92
Recent advances in lentiviral vector development and applications. Mol Ther (2010) 1.89
Digital transcriptome profiling from attomole-level RNA samples. Genome Res (2010) 1.83
Chromatin dynamics during cellular reprogramming. Nature (2013) 1.79
DNA methylation and cellular reprogramming. Trends Cell Biol (2010) 1.77
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res (2009) 1.77
Molecular roadblocks for cellular reprogramming. Mol Cell (2012) 1.74
A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients. Blood (2009) 1.74
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
iPS cells reprogrammed from human mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells Dev (2010) 1.73
Epigenetics of reprogramming to induced pluripotency. Cell (2013) 1.73
Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth. Circ Res (2011) 1.62
Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? Nat Rev Mol Cell Biol (2011) 1.58
CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation. Proc Natl Acad Sci U S A (2011) 1.57
C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature (2013) 1.57
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes. PLoS One (2010) 1.54
Reprogrammed mouse astrocytes retain a "memory" of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts. Protein Cell (2011) 1.52
Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol (2015) 1.48
Adult palatum as a novel source of neural crest-related stem cells. Stem Cells (2009) 1.45
The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells. Mol Syst Biol (2011) 1.44
Advances in reprogramming somatic cells to induced pluripotent stem cells. Stem Cell Rev (2010) 1.43
Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions. Stem Cells (2009) 1.41
Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape. Cell Res (2011) 1.41
iPS cell-derived cardiogenicity is hindered by sustained integration of reprogramming transgenes. Circ Cardiovasc Genet (2014) 1.40
A deterministic map of Waddington's epigenetic landscape for cell fate specification. BMC Syst Biol (2011) 1.21
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res (2012) 1.21
A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. Sci Rep (2012) 1.18
Stable isotope labeling by amino acids in cell culture (SILAC) and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells. Mol Cell Proteomics (2009) 1.17
Derivation of human induced pluripotent stem cells for cardiovascular disease modeling. Circ Res (2011) 1.17
A decade of transcription factor-mediated reprogramming to pluripotency. Nat Rev Mol Cell Biol (2016) 1.16
Safeguarding nonhuman primate iPS cells with suicide genes. Mol Ther (2011) 1.16
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol (2009) 1.15
Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors. PLoS One (2011) 1.15
Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes. Nucleic Acids Res (2011) 1.15
Gene and cell-mediated therapies for muscular dystrophy. Muscle Nerve (2013) 1.14
Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts. Proc Natl Acad Sci U S A (2013) 1.14
Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases. Mod Pathol (2011) 1.13
Stem cells derived from cord blood in transplantation and regenerative medicine. Dtsch Arztebl Int (2009) 1.13
Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurologic function in a rat model of middle cerebral artery occlusion. Stem Cell Res Ther (2013) 1.11
Autologous blood cell therapies from pluripotent stem cells. Blood Rev (2009) 1.09
Stem cells in plastic surgery: a review of current clinical and translational applications. Arch Plast Surg (2013) 1.09
Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells. Blood (2011) 1.08
Identification of inappropriately reprogrammed genes by large-scale transcriptome analysis of individual cloned mouse blastocysts. PLoS One (2010) 1.08
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007) 21.93
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
Stepwise reprogramming of B cells into macrophages. Cell (2004) 7.68
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J (2002) 6.83
Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell (1981) 6.31
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A (2001) 5.76
Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature (2007) 5.56
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature (2007) 5.39
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell (1982) 3.86
Pax5: the guardian of B cell identity and function. Nat Immunol (2007) 3.15
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07
The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A (2003) 2.99
Mice cloned from olfactory sensory neurons. Nature (2004) 2.90
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J Exp Med (1991) 2.88
Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity (2006) 2.64
Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity (2006) 2.58
Mouse cloning with nucleus donor cells of different age and type. Mol Reprod Dev (2001) 2.16
Reversion of B cell commitment upon loss of Pax5 expression. Science (2002) 2.16
From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. Annu Rev Cell Dev Biol (2006) 1.91
IL-7 does not prevent pro-B/pre-B cell maturation to the immature/sIgM(+) stage. Eur J Immunol (2004) 1.90
A CD133-expressing murine liver oval cell population with bilineage potential. Stem Cells (2007) 1.87
Immunoglobulin somatic hypermutation. Annu Rev Genet (2007) 1.87
Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr Biol (2005) 1.49
Murine lambda gene rearrangements: the stochastic model prevails over the ordered model. EMBO J (1990) 1.44
Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J (1992) 1.37
Mice cloned from skin cells. Proc Natl Acad Sci U S A (2007) 1.23
Role of TLR in B cell development: signaling through TLR4 promotes B cell maturation and is inhibited by TLR2. J Immunol (2005) 1.22
Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements. J Exp Med (2003) 1.02
Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells. Hepatology (2004) 1.01
The origin of hepatocytes. Gastroenterology (2005) 0.99
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature (2003) 6.78
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02
Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet (2002) 5.51
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell (2007) 5.29
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron (2006) 4.74
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem (2005) 3.97
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94