Wnt signaling promotes reprogramming of somatic cells to pluripotency.

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Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90

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A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64

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Transgenic mice with defined combinations of drug-inducible reprogramming factors. Nat Biotechnol (2009) 2.46

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Maintaining embryonic stem cell pluripotency with Wnt signaling. Development (2011) 1.57

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res (2010) 1.51

myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation (2010) 1.50

Canonical Wnt/β-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells (2010) 1.43

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Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Res (2012) 1.39

JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency. Nat Commun (2012) 1.37

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Cancer stem cells. Int J Biochem Cell Biol (2012) 1.35

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Derivation of human induced pluripotent stem cells for cardiovascular disease modeling. Circ Res (2011) 1.17

Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells (2013) 1.14

Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep (2013) 1.11

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth. Proc Natl Acad Sci U S A (2013) 1.11

Defined three-dimensional microenvironments boost induction of pluripotency. Nat Mater (2016) 1.11

Simple generation of human induced pluripotent stem cells using poly-beta-amino esters as the non-viral gene delivery system. J Biol Chem (2011) 1.06

Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming. PLoS One (2012) 1.06

Leukemia inhibitory factor (LIF)-dependent, pluripotent stem cells established from inner cell mass of porcine embryos. J Biol Chem (2011) 1.05

Linking cell signaling and the epigenetic machinery. Nat Biotechnol (2010) 1.03

Conserved expression patterns predict microRNA targets. PLoS Comput Biol (2009) 1.02

The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming. Stem Cell Reports (2014) 1.01

Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors. PLoS One (2012) 1.01

Safely targeting cancer stem cells via selective catenin coactivator antagonism. Cancer Sci (2014) 1.00

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MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs. PLoS One (2012) 0.99

Histone deacetylase inhibitors stimulate dedifferentiation of human breast cancer cells through WNT/β-catenin signaling. Stem Cells (2012) 0.97

Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors. Stem Cells (2011) 0.96

Combinatorial modulation of signaling pathways reveals cell-type-specific requirements for highly efficient and synchronous iPSC reprogramming. Stem Cell Reports (2014) 0.96

MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat Struct Mol Biol (2013) 0.95

Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles. Stem Cells Dev (2011) 0.95

T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications. Proc Natl Acad Sci U S A (2011) 0.94

A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling. Stem Cells (2015) 0.94

Mapping key features of transcriptional regulatory circuitry in embryonic stem cells. Cold Spring Harb Symp Quant Biol (2008) 0.93

Progress in the reprogramming of somatic cells. Circ Res (2013) 0.92

Proliferation rate of somatic cells affects reprogramming efficiency. J Biol Chem (2013) 0.92

Mechanistic insights into reprogramming to induced pluripotency. J Cell Physiol (2011) 0.92

Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A (2012) 0.91

The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies. Lab Invest (2015) 0.91

Downregulation of miR-452 promotes stem-like traits and tumorigenicity of gliomas. Clin Cancer Res (2013) 0.89

iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol Sin (2013) 0.89

miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway. Oncotarget (2015) 0.88

Temporal perturbation of the Wnt signaling pathway in the control of cell reprogramming is modulated by TCF1. Stem Cell Reports (2014) 0.88

Regulation of induced pluripotent stem (iPS) cell induction by Wnt/β-catenin signaling. J Biol Chem (2014) 0.88

The Wnt/β-catenin signaling pathway tips the balance between apoptosis and reprograming of cell fusion hybrids. Stem Cells (2010) 0.87

Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells (2014) 0.87

Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med (2011) 0.87

Watching reprogramming in real time. Nat Biotechnol (2009) 0.87

Reprogramming with Small Molecules instead of Exogenous Transcription Factors. Stem Cells Int (2015) 0.87

Intestinal stem cells and the colorectal cancer microenvironment. World J Gastroenterol (2014) 0.86

Small molecules and stem cells. Potency and lineage commitment: the new quest for the fountain of youth. J Med Chem (2010) 0.86

Induced pluripotent stem cells: emerging techniques for nuclear reprogramming. Antioxid Redox Signal (2011) 0.85

The use of small molecules in somatic-cell reprogramming. Trends Cell Biol (2013) 0.85

Induced pluripotent cancer cells: progress and application. J Cancer Res Clin Oncol (2010) 0.85

The path from skin to brain: generation of functional neurons from fibroblasts. Mol Neurobiol (2012) 0.85

Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells. PLoS One (2011) 0.85

Activated β-catenin forces N2A cell-derived neurons back to tumor-like neuroblasts and positively correlates with a risk for human neuroblastoma. Int J Biol Sci (2012) 0.85

Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine. J Am Coll Cardiol (2016) 0.85

The histone methyltransferase inhibitor BIX01294 enhances the cardiac potential of bone marrow cells. Stem Cells Dev (2012) 0.84

Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq. Nat Cell Biol (2013) 0.84

EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. J Hepatol (2016) 0.84

HPV-16 E6 promotes cell growth of esophageal cancer via downregulation of miR-125b and activation of Wnt/β-catenin signaling pathway. Int J Clin Exp Pathol (2015) 0.83

Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev (2013) 0.83

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors. Development (2015) 0.83

Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives. Stem Cells Cloning (2015) 0.82

A stochastic model dissects cell states in biological transition processes. Sci Rep (2014) 0.82

Inhibition of transforming growth factor β (TGF-β) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotency. J Biol Chem (2014) 0.82

Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy. Expert Opin Ther Targets (2015) 0.81

Reprogramming fibroblasts to pluripotency using arginine-terminated polyamidoamine nanoparticles based non-viral gene delivery system. Int J Nanomedicine (2014) 0.81

Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation. Stem Cell Reports (2016) 0.81

Nuclear F-actin enhances the transcriptional activity of β-catenin by increasing its nuclear localization and binding to chromatin. Histochem Cell Biol (2016) 0.80

Genetic background affects induced pluripotent stem cell generation. Stem Cell Res Ther (2012) 0.80

A poor imitation of a natural process: a call to reconsider the iPSC engineering technique. Cell Cycle (2012) 0.80

Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation. Stem Cells Dev (2011) 0.80

Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells. Stem Cell Res Ther (2012) 0.80

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50

Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24

Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol (2007) 21.93

The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44

Wnt signalling in stem cells and cancer. Nature (2005) 19.26

An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med (2003) 12.94

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04

c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52

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T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells (2008) 2.43

Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells (2008) 2.20

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wnt3a but not wnt11 supports self-renewal of embryonic stem cells. Biochem Biophys Res Commun (2006) 1.53

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48

Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93

Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29

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Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21

Transcriptional regulatory code of a eukaryotic genome. Nature (2004) 27.21

Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90

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A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38

Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13

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Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34

BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell (2011) 14.34

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29

Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05

Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78

Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76

c-Myc regulates transcriptional pause release. Cell (2010) 11.64

Divergent transcription from active promoters. Science (2008) 11.03

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev (2002) 10.06

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84

RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet (2007) 9.56

Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell (2013) 9.55

Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25

HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04

Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86

Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69

Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48

c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46

Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell (2013) 8.37

Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24

YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52

Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50

Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc (2006) 7.29

Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17

Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell (2011) 7.03

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56

Computational discovery of gene modules and regulatory networks. Nat Biotechnol (2003) 6.55

Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet (2004) 6.33

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Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02

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Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40

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Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00

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Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev (2008) 4.77

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Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67

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Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59

Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52

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Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell (2010) 4.36

Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol Cell (2002) 4.35

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32

Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16

Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling. Cell (2003) 4.12