Published in Trends Cell Biol on March 05, 2012
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol (2015) 2.02
PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells. PLoS One (2016) 1.37
Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells. Br J Cancer (2013) 1.14
Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors. Elife (2014) 0.98
Notch signaling during cell fate determination in the inner ear. Semin Cell Dev Biol (2013) 0.97
Hajdu-Cheney syndrome: a review. Orphanet J Rare Dis (2014) 0.93
Beyond NF-κB activation: nuclear functions of IκB kinase α. J Biomed Sci (2013) 0.93
Notch is a direct negative regulator of the DNA-damage response. Nat Struct Mol Biol (2015) 0.90
Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Mol Cell Biol (2013) 0.88
Notch signaling pathway and human placenta. Int J Med Sci (2012) 0.88
Notch signaling: its roles and therapeutic potential in hematological malignancies. Oncotarget (2016) 0.87
Ligand-Independent Mechanisms of Notch Activity. Trends Cell Biol (2015) 0.84
The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia. J Pathol (2013) 0.83
Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β. Oncotarget (2015) 0.82
Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells. PLoS One (2014) 0.82
Crosstalk between Nrf2 and Notch signaling. Free Radic Biol Med (2015) 0.82
Stem cells in gastrointestinal cancers: The road less travelled. World J Stem Cells (2014) 0.81
Reinforcing targeted therapeutics with phenotypic stability factors. Cell Cycle (2014) 0.81
Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function. Front Physiol (2014) 0.81
BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. Elife (2016) 0.80
Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis. Ann N Y Acad Sci (2014) 0.80
The NOTCH signaling pathway in normal and malignant blood cell production. J Cell Commun Signal (2015) 0.80
Expression of notch family proteins in placentas from patients with early-onset severe preeclampsia. Reprod Sci (2013) 0.80
From Drosophila development to adult: clues to Notch function in long-term memory. Front Cell Neurosci (2013) 0.80
No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One (2012) 0.80
Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway. Biochem Pharmacol (2016) 0.80
Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells. PLoS One (2014) 0.79
Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway. World J Gastroenterol (2016) 0.78
Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad. Oxid Med Cell Longev (2016) 0.78
The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks. Hippocampus (2015) 0.78
Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice. Cancer Res (2016) 0.78
Notch Signaling in Neuroendocrine Tumors. Front Oncol (2016) 0.78
A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death. Mol Cell Biol (2015) 0.77
Transglutaminase 2--a novel inhibitor of adipogenesis. Cell Death Dis (2015) 0.77
Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology. J Cancer Res Clin Oncol (2015) 0.76
Notch signaling represses hypoxia-inducible factor-1α-induced activation of Wnt/β-catenin signaling in osteoblasts under cobalt-mimicked hypoxia. Mol Med Rep (2016) 0.76
Notch Intracellular Domain (NICD) Suppresses Long-Term Memory Formation in Adult Drosophila Flies. Cell Mol Neurobiol (2015) 0.76
Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis. Cell Death Dis (2016) 0.76
Interaction of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells. Cell Mol Neurobiol (2013) 0.76
Notch-Mediated Cell Adhesion. Biology (Basel) (2016) 0.76
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity. Stem Cell Reports (2017) 0.76
Requirement of HDAC6 for activation of Notch1 by TGF-β1. Sci Rep (2016) 0.76
Coins of the realm in atrioventricular junction development. Circ Res (2015) 0.75
Glycosylated Notch and Cancer. Front Oncol (2016) 0.75
NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex. Cell Rep (2016) 0.75
Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis. Elife (2016) 0.75
A dual molecular analogue tuner for dissecting protein function in mammalian cells. Nat Commun (2016) 0.75
The role of Notch signaling in the mammalian ovary. Reproduction (2017) 0.75
Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun (2017) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev (1999) 6.56
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer (2003) 4.75
Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron (1996) 4.69
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell (1994) 4.24
The suppressor of hairless protein participates in notch receptor signaling. Cell (1994) 3.81
Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. Ann Intern Med (2007) 3.64
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest (2003) 3.50
Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell (1997) 3.48
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol (1995) 3.46
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell (1993) 3.35
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell (2002) 3.16
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 2.94
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development (1996) 2.92
Asymmetric segregation of Numb and Prospero during cell division. Nature (1995) 2.87
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development (2006) 2.82
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell (1989) 2.72
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol Cell Biol (1994) 2.71
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep (2001) 2.70
Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. J Biol Chem (1999) 2.65
Notch and cancer: a double-edged sword. Cell Mol Life Sci (2007) 2.59
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A (2007) 2.56
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts. Development (1999) 2.55
Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron (1996) 2.44
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A (2009) 2.34
The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch. Nature (1988) 2.27
Notch tumor suppressor function. Oncogene (2008) 2.26
Wnt/Notch signalling and information processing during development. Development (2008) 2.18
LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway. Nature (2000) 2.17
Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J (2005) 2.16
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. Genes Dev (1994) 2.08
Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol (1998) 1.99
Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila. Curr Biol (2001) 1.91
Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89
Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Invest (1995) 1.81
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol (2009) 1.73
Notch is required for wingless signaling in the epidermis of Drosophila. Cell (1994) 1.67
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol (2011) 1.66
Glycogen synthase kinase-3beta modulates notch signaling and stability. Curr Biol (2002) 1.66
Rethinking WNT signaling. Trends Genet (2004) 1.63
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62
Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. Science (2011) 1.61
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol (1999) 1.61
RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2. Nucleic Acids Res (1995) 1.61
Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. J Biol Chem (2006) 1.61
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr Biol (2001) 1.55
Ligand-induced signaling in the absence of furin processing of Notch1. Dev Biol (2001) 1.51
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res (2010) 1.45
The notch intracellular domain can function as a coactivator for LEF-1. Mol Cell Biol (2001) 1.45
Wnt pathway activation: new relations and locations. Cell (2005) 1.43
Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors. J Cell Biol (2010) 1.39
Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc Natl Acad Sci U S A (1996) 1.27
Wnt signaling and dorso-ventral axis specification in vertebrates. Curr Opin Genet Dev (1999) 1.25
Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development. Development (2002) 1.25
Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras. J Biol Chem (2007) 1.23
Bafilomycin A1 inhibits lysosomal, phagosomal, and plasma membrane H(+)-ATPase and induces lysosomal enzyme secretion in macrophages. J Cell Physiol (1995) 1.19
An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila. Curr Biol (1999) 1.19
Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo. Mech Dev (1998) 1.10
Wnt signaling and phosphorylation status of beta-catenin: importance of the correct antibody tools. Blood (2007) 1.03
Evidence for a novel Notch pathway required for muscle precursor selection in Drosophila. Mech Dev (1998) 1.03
Identification and characterization of presenilin-independent Notch signaling. J Biol Chem (2001) 1.00
Modulation of wingless signaling by Notch in Drosophila. Mech Dev (1994) 0.99
Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis. J Biol Chem (2003) 0.97
Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila. PLoS Biol (2009) 0.96
The abruptex mutations of notch disrupt the establishment of proneural clusters in Drosophila. Dev Biol (1999) 0.96
Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway. Mol Cell Biol (2005) 0.94
Repression by Notch is required before Wingless signalling during muscle progenitor cell development in Drosophila. Curr Biol (1999) 0.92
A role of receptor Notch in ligand cis-inhibition in Drosophila. Curr Biol (2010) 0.89
Celecoxib induces dose dependent growth inhibition in nasopharyngeal carcinoma cell lines independent of cyclooxygenase-2 expression. Biomed Pharmacother (2005) 0.89
Wingless modulates the effects of dominant negative notch molecules in the developing wing of Drosophila. Dev Biol (1999) 0.88
Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development. Dev Growth Differ (2003) 0.83
Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila. Development (2011) 0.82
Notch destabilises maternal beta-catenin and restricts dorsal-anterior development in Xenopus. Development (2011) 0.79
A widespread and early requirement for a novel Notch function during Drosophila embryogenesis. Dev Biol (1999) 0.76
Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation (2008) 3.11
Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors. J Cell Biol (2010) 1.39
Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One (2011) 1.33
Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization. Stem Cells (2012) 1.27
Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes. Stem Cells (2007) 1.17
Randomized, controlled trial of intramuscular or intracoronary injection of autologous bone marrow cells into scarred myocardium during CABG versus CABG alone. Nat Clin Pract Cardiovasc Med (2008) 1.13
Limitations of conventional approaches to identify myocyte nuclei in histologic sections of the heart. Am J Physiol Cell Physiol (2010) 1.09
Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. Biochem Biophys Res Commun (2008) 0.98
Epigenetic factors and cardiac development. Cardiovasc Res (2011) 0.97
Fibronectin mediates mesendodermal cell fate decisions. Development (2013) 0.95
A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Dev Cell (2011) 0.93
The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res (2009) 0.92
Direct contact with endoderm-like cells efficiently induces cardiac progenitors from mouse and human pluripotent stem cells. PLoS One (2012) 0.90
Regenerative medicine for the heart: perspectives on stem-cell therapy. Antioxid Redox Signal (2014) 0.87
Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet (2013) 0.86
Fluctuation theorems and entropy production with odd-parity variables. Phys Rev Lett (2013) 0.75
Multiple dynamic transitions in nonequilibrium work fluctuations. Phys Rev Lett (2013) 0.75
Everlasting initial memory threshold for rare events in equilibration processes. Phys Rev E Stat Nonlin Soft Matter Phys (2013) 0.75