Published in Cancer Res on April 21, 2009
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell (2011) 2.06
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
The regulatory crosstalk between kinases and proteases in cancer. Nat Rev Cancer (2010) 1.80
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem (2010) 1.75
Neuroblastoma and MYCN. Cold Spring Harb Perspect Med (2013) 1.75
Caspase control: protagonists of cancer cell apoptosis. Exp Oncol (2012) 1.69
Rab5 mediates caspase-8-promoted cell motility and metastasis. Mol Biol Cell (2009) 1.28
Metastasis suppressor genes at the interface between the environment and tumor cell growth. Int Rev Cell Mol Biol (2011) 1.18
Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact. PLoS One (2010) 1.11
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance. Cancer Res (2011) 1.05
Metastasis suppressors and the tumor microenvironment. Semin Cancer Biol (2010) 1.03
The executioners sing a new song: killer caspases activate microglia. Cell Death Differ (2011) 1.02
Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J Biol Chem (2011) 0.98
Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin. Cell Death Differ (2010) 0.96
Impact of heparanase and the tumor microenvironment on cancer metastasis and angiogenesis: basic aspects and clinical applications. Rambam Maimonides Med J (2011) 0.92
The death effector domains of caspase-8 induce terminal differentiation. PLoS One (2009) 0.92
Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. Am J Cancer Res (2011) 0.91
Integrin adhesions: who's on first? What's on second? Connections between FAK and talin. Cell Adh Migr (2012) 0.90
Caspase-8 as a therapeutic target in cancer. Cancer Lett (2010) 0.89
New roles for old enzymes: killer caspases as the engine of cell behavior changes. Front Physiol (2014) 0.89
FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma. Mol Biol Cell (2012) 0.86
Caspase-8 as a regulator of tumor cell motility. Curr Mol Med (2014) 0.85
Killing me softly--future challenges in apoptosis research. Int J Mol Sci (2014) 0.83
Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adh Migr (2013) 0.79
MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness. Cell Death Dis (2014) 0.76
The enigmatic roles of caspases in tumor development. Cancers (Basel) (2010) 0.76
More than the genes, the tumor microenvironment in neuroblastoma. Cancer Lett (2015) 0.76
Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma. BMC Cancer (2013) 0.75
Novel role of ASC as a regulator of metastatic phenotype. Cancer Med (2016) 0.75
Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes. World J Gastroenterol (2015) 0.75
Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis. Oncotarget (2016) 0.75
Integrins in the Spotlight of Cancer. Int J Mol Sci (2016) 0.75
Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy. Oncotarget (2016) 0.75
Triptolide-Mediated Apoptosis by Suppression of Focal Adhesion Kinase through Extrinsic and Intrinsic Pathways in Human Melanoma Cells. Evid Based Complement Alternat Med (2013) 0.75
Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity (1998) 6.07
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med (2000) 5.04
Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol (2004) 4.29
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science (2005) 3.64
Intracellular signalling controlling integrin activation in lymphocytes. Nat Rev Immunol (2005) 3.54
The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis (2007) 3.16
Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol (2004) 3.09
Regulating cell migration: calpains make the cut. J Cell Sci (2005) 3.03
Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol (2001) 2.99
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem Biol (2000) 2.84
Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci (2002) 2.62
Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem (1997) 2.52
Molecular ordering of the initial signaling events of CD95. Mol Cell Biol (2002) 2.36
Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta (2006) 2.18
Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature (2006) 2.12
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J (2004) 2.12
Activation of caspases-8 and -10 by FLIP(L). Biochem J (2004) 2.11
Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J (1994) 2.08
Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J Biol Chem (2001) 1.91
Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res (2001) 1.85
Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. J Biol Chem (2001) 1.80
Activity-based protein profiling for the functional annotation of enzymes. Nat Methods (2007) 1.70
Apoptosome dysfunction in human cancer. Apoptosis (2004) 1.70
A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol (2003) 1.67
Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. J Biol Chem (2007) 1.66
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J (2006) 1.64
Talin controls integrin activation. Biochem Soc Trans (2004) 1.61
Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology (2003) 1.56
Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem (2004) 1.46
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell (2006) 1.43
Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med (2005) 1.40
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res (2006) 1.37
The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol Cell Biol (2002) 1.36
Interaction of calpastatin with calpain: a review. Biol Chem (2004) 1.34
Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility. Cancer Res (2007) 1.33
Caspase-8: fly or die. Cancer Res (2008) 1.26
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J Biol Chem (2008) 1.25
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death. J Mol Med (Berl) (2001) 1.22
CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Res (2005) 1.20
Comprehensive studies on subcellular localizations and cell death-inducing activities of eight GFP-tagged apoptosis-related caspases. Exp Cell Res (2001) 1.17
Tumor microenvironment and drug resistance in hematologic malignancies. Blood Rev (2006) 1.16
Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome. Clin Cancer Res (2007) 1.13
Caspase-8 sumoylation is associated with nuclear localization. Oncogene (2005) 1.06
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A (2008) 1.05
A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes. Carcinogenesis (2005) 0.99
Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease? J Biol Chem (2006) 0.94
Digestive versus regulatory proteases: on calpain action in vivo. Biol Chem (2005) 0.94
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene (2001) 0.94
Ligand bound beta1 integrins inhibit procaspase-8 for mediating cell adhesion-mediated drug and radiation resistance in human leukemia cells. PLoS One (2007) 0.92
Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma. Med Pediatr Oncol (2000) 0.92
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell (2004) 4.38
Defective planar cell polarity in polycystic kidney disease. Nat Genet (2005) 4.31
A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature (2008) 3.74
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Nat Chem Biol (2008) 3.16
MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med (2010) 2.99
Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat Chem Biol (2005) 2.90
Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol (2002) 2.84
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol (2007) 2.80
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell (2004) 2.44
Activity-based probes that target diverse cysteine protease families. Nat Chem Biol (2005) 2.21
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res (2006) 2.20
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science (2002) 2.20
Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature (2006) 2.12
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med (2009) 2.10
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem (2006) 2.05
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem (2002) 2.03
Role of Raf in vascular protection from distinct apoptotic stimuli. Science (2003) 2.02
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med (2011) 1.93
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat Med (2009) 1.90
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
Chemical approaches for functionally probing the proteome. Mol Cell Proteomics (2002) 1.78
Tagging and detection strategies for activity-based proteomics. Curr Opin Chem Biol (2006) 1.70
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A (2010) 1.67
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (2008) 1.67
Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66
Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J (2006) 1.64
Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chem Biol (2010) 1.60
Rab35 controls actin bundling by recruiting fascin as an effector protein. Science (2009) 1.51
Regulation of collagenase activities of human cathepsins by glycosaminoglycans. J Biol Chem (2003) 1.46
Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery. Am J Pharmacogenomics (2004) 1.45
A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB. Chem Biol (2013) 1.44
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell (2006) 1.43
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design. Chem Biol (2002) 1.42
Effect of salmeterol on seasonal changes in airway responsiveness and exhaled nitric oxide in pollen-sensitive asthmatic subjects. Chest (2002) 1.42
The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. J Cell Sci (2006) 1.42
c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J (2002) 1.41
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther (2010) 1.41
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol (2011) 1.41
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res (2006) 1.37
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nat Chem Biol (2009) 1.36
Activity profiling of papain-like cysteine proteases in plants. Plant Physiol (2004) 1.36
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res (2009) 1.35
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol (2003) 1.34
A mild chemically cleavable linker system for functional proteomic applications. Angew Chem Int Ed Engl (2007) 1.33
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem (2009) 1.33
CDK11 complexes promote pre-mRNA splicing. J Biol Chem (2002) 1.33
VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res (2009) 1.32
Role of CDK/cyclin complexes in transcription and RNA splicing. Cell Signal (2005) 1.32
Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. Curr Opin Chem Biol (2011) 1.31
The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf. BMC Genomics (2005) 1.29
Rab5 mediates caspase-8-promoted cell motility and metastasis. Mol Biol Cell (2009) 1.28
Synthetic mRNA splicing modulator compounds with in vivo antitumor activity. J Med Chem (2009) 1.28
Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem (2003) 1.27
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages. Chem Biol (2012) 1.27
Activity-based probes as a tool for functional proteomic analysis of proteases. Expert Rev Proteomics (2008) 1.26
Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase. J Cell Sci (2002) 1.25
Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle (2007) 1.25
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J Biol Chem (2008) 1.25
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res (2007) 1.24
GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic. J Cell Sci (2006) 1.24
Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J Biol Chem (2008) 1.24
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem (2004) 1.24
Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity. Cell Res (2006) 1.22
Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells. Biochim Biophys Acta (2008) 1.21
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes. Chem Biol (2010) 1.20
Integrin-mediated death: an explanation of the integrin-knockout phenotype? Nat Med (2002) 1.20
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis (2012) 1.20
CDK11(p58) is required for the maintenance of sister chromatid cohesion. J Cell Sci (2007) 1.20
Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth. Mol Microbiol (2004) 1.19
Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag. PLoS One (2009) 1.19
Hepatitis C virus stabilizes hypoxia-inducible factor 1alpha and stimulates the synthesis of vascular endothelial growth factor. J Virol (2007) 1.19
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol Cancer Res (2007) 1.18
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol (2009) 1.17
Application of activity-based probes to the study of enzymes involved in cancer progression. Curr Opin Genet Dev (2008) 1.17
PITSLRE p110 protein kinases associate with transcription complexes and affect their activity. J Biol Chem (2001) 1.16
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem (2005) 1.16
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. PLoS Pathog (2006) 1.15
Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance. PLoS One (2012) 1.15
Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell (2006) 1.14
Using small molecules to dissect mechanisms of microbial pathogenesis. ACS Chem Biol (2009) 1.14
Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc (2013) 1.14
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chem Biol (2010) 1.13
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Res (2007) 1.13
Management of cerebral aneurysms in autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2002) 1.12
New approaches for dissecting protease functions to improve probe development and drug discovery. Nat Struct Mol Biol (2012) 1.11
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Proc Natl Acad Sci U S A (2009) 1.11
Activity-based profiling of proteases. Annu Rev Biochem (2014) 1.10
Topical application of activity-based probes for visualization of brain tumor tissue. PLoS One (2012) 1.10
Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening. Curr Pharm Des (2007) 1.10