Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMC 3071691)

Published in J Immunol on February 01, 2006

Authors

Mette Møller-Kristensen1, W K Eddie Ip, Lei Shi, Lakshmi D Gowda, Michael R Hamblin, Steffen Thiel, Jens Chr Jensenius, R Alan B Ezekowitz, Kazue Takahashi

Author Affiliations

1: Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Articles citing this

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med (2008) 1.64

Local inflammation induces complement crosstalk which amplifies the antimicrobial response. PLoS Pathog (2009) 1.10

Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. Immunobiology (2010) 1.10

Phase I safety, tolerability, and pharmacokinetic study of recombinant human mannan-binding lectin. J Clin Immunol (2006) 1.09

High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus. Immunobiology (2010) 0.93

Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin. Biochem Pharmacol (2010) 0.90

Mannose-binding lectin and the balance between immune protection and complication. Expert Rev Anti Infect Ther (2011) 0.89

Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice. J Invest Dermatol (2007) 0.89

Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage. J Immunol Methods (2007) 0.89

The role of mannose-binding lectin in severe sepsis and septic shock. Mediators Inflamm (2013) 0.87

Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum. Part Fibre Toxicol (2014) 0.86

Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis. J Immunol (2011) 0.84

Mannose-binding lectin binds to amyloid β protein and modulates inflammation. J Biomed Biotechnol (2012) 0.82

Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors. Bone Marrow Transplant (2009) 0.82

Mannan-binding lectin in cardiovascular disease. Biomed Res Int (2014) 0.81

Serum mannose-binding lectin concentration, but not genotype, is associated with Clostridium difficile infection recurrence: a prospective cohort study. Clin Infect Dis (2014) 0.81

Mannose-binding lectin deficiency influences innate and antigen-presenting functions of blood myeloid dendritic cells. Immunology (2010) 0.81

Complement 3 is involved with ventilator-induced lung injury. Int Immunopharmacol (2011) 0.81

Single-nucleotide polymorphisms in porcine mannan-binding lectin A. Immunogenetics (2006) 0.80

Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi. PLoS One (2012) 0.80

Activation of the lectin pathway of complement in experimental human keratitis with Pseudomonas aeruginosa. Mol Vis (2014) 0.80

Mannan-binding lectin is a determinant of survival in infective endocarditis. Clin Exp Immunol (2007) 0.79

Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes. Open Orthop J (2015) 0.75

Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study. Virus Res (2013) 0.75

C-type lectin receptors in tuberculosis: what we know. Med Microbiol Immunol (2016) 0.75

Articles cited by this

National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control (2004) 14.85

Phylogenetic perspectives in innate immunity. Science (1999) 9.42

Mammalian defensins in the antimicrobial immune response. Nat Immunol (2005) 4.84

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med (2001) 4.54

By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell (2003) 3.65

A second serine protease associated with mannan-binding lectin that activates complement. Nature (1997) 3.64

Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol (2004) 3.57

Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med (2005) 3.52

Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet (1989) 3.12

Molecular basis of opsonic defect in immunodeficient children. Lancet (1991) 3.00

Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol (2001) 2.90

Burn wound infections: current status. World J Surg (1998) 2.86

Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J Exp Med (1992) 2.76

Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun (2000) 2.71

Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet (2001) 2.64

Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet (2001) 2.60

Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods (2000) 2.22

Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice. J Virol (1997) 2.18

Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med (2004) 2.12

Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol (1998) 2.11

Optical monitoring and treatment of potentially lethal wound infections in vivo. J Infect Dis (2003) 1.98

Historical review of the use of silver in the treatment of burns. I. Early uses. Burns (2000) 1.90

Macrophages and post-burn immune dysfunction. Burns (2003) 1.84

Twenty-five year review of Pseudomonas aeruginosa bacteremia in a burn center. Eur J Clin Microbiol (1985) 1.72

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol (2005) 1.69

Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol (2003) 1.66

Distinct and overlapping functions of allelic forms of human mannose binding protein. Nat Genet (1992) 1.66

Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans. J Immunol (1999) 1.64

The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity. Semin Immunol (1998) 1.60

Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. J Immunol (2002) 1.52

The collectins in innate immunity. Curr Opin Immunol (1996) 1.46

The role of matrix metalloproteinases in wound healing. J Am Podiatr Med Assoc (2002) 1.41

Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Blood (2002) 1.39

Bacteriology of burns. Burns (1998) 1.36

Pseudomonas infections in the thermally injured patient. Burns (2004) 1.29

Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Immunobiology (2002) 1.29

The role of Toll-like receptors in host defense against microbial infection. Curr Opin Immunol (2001) 1.15

Microbiologic aspects of predominant bacteria isolated from the burn patients in Korea. Burns (2001) 1.12

Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses. Scand J Immunol (2001) 1.08

The potential role of mannan-binding lectin in the clearance of self-components including immune complexes. Scand J Immunol (2004) 1.06

Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis. Infect Immun (2001) 1.05

Mannan-binding lectin modulates the response to HSV-2 infection. Clin Exp Immunol (2004) 1.02

Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage. Scand J Immunol (1999) 1.02

Pathophysiologic events related to thermal injury of skin. J Trauma (1990) 1.00

Host defense peptides in burns. Burns (2004) 0.99

Ligand-binding characteristics of rat serum-type mannose-binding protein (MBP-A). Homology of binding site architecture with mammalian and chicken hepatic lectins. J Biol Chem (1991) 0.99

Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship. Clin Exp Immunol (2005) 0.99

Immunological responses to thermal injury. Burns (1997) 0.97

Low levels of mannose-binding lectin do not affect occurrence of severe infections or duration of fever in acute myeloid leukaemia during remission induction therapy. Eur J Haematol (2003) 0.97

Differential microorganism-induced mannose-binding lectin activation. FEMS Immunol Med Microbiol (2003) 0.96

Microvascular permeability to macromolecules in thermal injury. Acta Physiol Scand Suppl (1979) 0.95

Comparison of translocation of different types of microorganisms from the intestinal tract of burned mice. Shock (2001) 0.95

Distribution and survival of Escherichia coli translocating from the intestine after thermal injury. Ann Surg (1991) 0.95

North American survey of hydrotherapy in modern burn care. J Burn Care Rehabil (1994) 0.95

Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer. Scand J Gastroenterol (2004) 0.94

Differential recognition of core and terminal portions of oligosaccharide ligands by carbohydrate-recognition domains of two mannose-binding proteins. J Biol Chem (1990) 0.92

Neutrophils and keratinocytes in innate immunity--cooperative actions to provide antimicrobial defense at the right time and place. J Leukoc Biol (2004) 0.92

Burning the largest immune organ. Burns (1995) 0.89

Cytokine induction by the P. aeruginosa quorum sensing system during thermal injury. J Surg Res (2004) 0.89

Plasma cytokine levels in patients with severe burn injury--with reference to the relationship between infection and prognosis. Burns (1996) 0.89

Circulating levels of tumour necrosis factor, interleukin 6 and proteolytic activity in a murine model of burn and infection. Burns (1996) 0.85

Nosocomial infections in intensive care units: an overview of their epidemiology, outcome, and prevention. New Horiz (1993) 0.83

Mannose-binding protein, genetic variants and the risk of infection. QJM (1996) 0.83

Mannan-binding lectin and hepatitis C infection. Clin Exp Immunol (2003) 0.83

Mannan-binding lectin (MBL) serum levels and post-operative infections. Biochem Soc Trans (2003) 0.82

Tail-vein injection of mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver. Mol Ther (2001) 0.80

Articles by these authors

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol (2007) 6.69

Photodynamic therapy of cancer: an update. CA Cancer J Clin (2011) 6.08

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86

Arthritis critically dependent on innate immune system players. Immunity (2002) 5.31

Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature (2002) 4.33

Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer (2006) 3.93

Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol (2012) 3.86

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

Phagocytosis: elegant complexity. Immunity (2005) 3.27

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol Pharmacol (2006) 3.23

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell (2005) 3.22

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem (2008) 3.01

Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J (2008) 2.99

Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol (2001) 2.90

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol (2005) 2.89

SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A (2006) 2.89

Biphasic dose response in low level light therapy. Dose Response (2009) 2.78

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem (2002) 2.75

The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation (2012) 2.55

Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature (2010) 2.41

The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng (2011) 2.37

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A (2005) 2.33

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci (2006) 2.30

Twin-spot MARCM to reveal the developmental origin and identity of neurons. Nat Neurosci (2009) 2.26

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proc Natl Acad Sci U S A (2009) 2.25

Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis (2008) 2.20

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat Struct Mol Biol (2010) 2.20

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature (2011) 2.18

Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med (2004) 2.12

Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med (2009) 2.10

Local resistance switching at grain and grain boundary surfaces of polycrystalline tungsten oxide films. Nanotechnology (2011) 2.09

Mannose-binding lectin and innate immunity. Immunol Rev (2009) 2.08

An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem (2008) 2.07

Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q. J Immunol (2005) 2.02

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. J Biol Chem (2006) 2.01

4-[18F]-tetraphenylphosphonium as a PET tracer for myocardial mitochondrial membrane potential. JACC Cardiovasc Imaging (2012) 1.94

Additional support for a revised Gibbs analysis. Langmuir (2010) 1.94

Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab (2003) 1.93

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. J Immunol (2005) 1.89

Effect of cell-photosensitizer binding and cell density on microbial photoinactivation. Antimicrob Agents Chemother (2005) 1.89

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. J Med Chem (2012) 1.87

Role of low-level laser therapy in neurorehabilitation. PM R (2010) 1.79

Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach. Proc Natl Acad Sci U S A (2009) 1.79

Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J Immunol (2006) 1.78

Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. PLoS One (2011) 1.76

Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens. Gut (2010) 1.75

Photodynamic therapy for localized infections--state of the art. Photodiagnosis Photodyn Ther (2009) 1.73

L-ficolin is a pattern recognition molecule specific for acetyl groups. J Biol Chem (2004) 1.70

Biphasic dose response in low level light therapy - an update. Dose Response (2011) 1.69

Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest (2006) 1.69

Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol (2005) 1.69

Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol (2011) 1.68

NEK2 induces drug resistance mainly through activation of efflux drug pumps and is associated with poor prognosis in myeloma and other cancers. Cancer Cell (2013) 1.67

Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase. Biochemistry (2007) 1.66

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65

NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry (2008) 1.65

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med (2008) 1.64

Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones. ChemMedChem (2008) 1.64

Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect Immun (2005) 1.64

SABIO-RK--database for biochemical reaction kinetics. Nucleic Acids Res (2011) 1.63

Metronidazole-flavonoid derivatives as anti-Helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8 production by AGS cells. ChemMedChem (2007) 1.62

An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell (2012) 1.61

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet (2006) 1.61

HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Mol Cell (2011) 1.59

microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis (2010) 1.59

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59

A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J Virol (2005) 1.59

Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetes (2004) 1.59

Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother (2006) 1.58

Rapid learning in cortical coding of visual scenes. Nat Neurosci (2007) 1.58

Targeted photodynamic therapy of established soft-tissue infections in mice. Photochem Photobiol Sci (2004) 1.57

Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method. Proc Natl Acad Sci U S A (2011) 1.57

Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Eur J Med Chem (2007) 1.57

Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association. J Leukoc Biol (2011) 1.55

An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit. Nucleic Acids Res (2005) 1.55

Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals. J Immunol Methods (2003) 1.54

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology (2005) 1.54

Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med (2003) 1.52

Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. Biomaterials (2006) 1.51

Photodynamic therapy for Acinetobacter baumannii burn infections in mice. Antimicrob Agents Chemother (2009) 1.50

Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J Photochem Photobiol B (2005) 1.50

Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.49

Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infect Immun (2005) 1.48

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS One (2011) 1.48