Published in Biochemistry on June 18, 2008
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
DNA helicases involved in DNA repair and their roles in cancer. Nat Rev Cancer (2013) 1.58
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys (2013) 1.57
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Semin Cancer Biol (2010) 1.44
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology (2008) 1.34
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
Non-homologous end joining in class switch recombination: the beginning of the end. Philos Trans R Soc Lond B Biol Sci (2009) 1.08
RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res (2011) 1.08
Processing of damaged DNA ends for double-strand break repair in mammalian cells. ISRN Mol Biol (2012) 0.98
Genome maintenance and transcription integrity in aging and disease. Front Genet (2013) 0.95
BCR/ABL stimulates WRN to promote survival and genomic instability. Cancer Res (2010) 0.94
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA Repair (Amst) (2010) 0.88
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. J Proteome Res (2011) 0.88
Metabolism, genomics, and DNA repair in the mouse aging liver. Curr Gerontol Geriatr Res (2011) 0.84
Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase. DNA Repair (Amst) (2009) 0.83
Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions. Ageing Res Rev (2016) 0.82
Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. Elife (2016) 0.81
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks. Aging (Albany NY) (2014) 0.81
Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes. Mech Ageing Dev (2010) 0.81
The role of RecQ helicases in non-homologous end-joining. Crit Rev Biochem Mol Biol (2014) 0.81
Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One (2011) 0.80
RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex. Carcinogenesis (2014) 0.77
Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? Genome Integr (2012) 0.76
Werner syndrome protein positively regulates XRCC4-like factor transcription. Mol Med Rep (2014) 0.75
WRN regulates pathway choice between classical and alternative non-homologous end joining. Nat Commun (2016) 0.75
Recent Advances in Understanding Werner Syndrome. F1000Res (2017) 0.75
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A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell (2004) 3.01
Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol Cell Biol (2000) 2.93
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Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol (2002) 2.25
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity. EMBO J (2001) 2.21
Ku complex interacts with and stimulates the Werner protein. Genes Dev (2000) 2.21
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Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mutat Res (1999) 2.08
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem (2001) 2.02
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) (2004) 1.93
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO. Nucleic Acids Res (1999) 1.90
The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem (1999) 1.84
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J (2007) 1.80
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res (1998) 1.80
Possible association of BLM in decreasing DNA double strand breaks during DNA replication. EMBO J (2000) 1.78
Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci (2005) 1.59
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol (2006) 1.55
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70. Science (2001) 1.52
Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol (2006) 1.45
Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc Natl Acad Sci U S A (2000) 1.42
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis (2003) 1.37
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res (2006) 1.34
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein. J Biol Chem (2001) 1.32
Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. J Biol Chem (2001) 1.30
Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model. Cell Cycle (2005) 1.28
Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases. J Biol Chem (2000) 1.25
Genetic interactions between BLM and DNA ligase IV in human cells. J Biol Chem (2004) 1.25
Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells. EMBO J (1989) 1.06
The BLM helicase is necessary for normal DNA double-strand break repair. Cancer Res (2002) 0.99
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Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing. Nucleic Acids Res (2003) 0.91
Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining. Biochemistry (2007) 0.87
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
DNA repair is limiting for haematopoietic stem cells during ageing. Nature (2007) 4.71
Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function. J Mol Biol (2005) 3.33
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem (2002) 2.53
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY) (2009) 2.50
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst) (2006) 2.43
Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42
No association between telomere length and survival among the elderly and oldest old. Epidemiology (2006) 2.33
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem (2005) 2.11
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70
Human RecQ helicases in DNA repair, recombination, and replication. Annu Rev Biochem (2014) 1.68
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol (2013) 1.67
A topological mechanism for TRF2-enhanced strand invasion. Nat Struct Mol Biol (2007) 1.65
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem (2005) 1.64
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci U S A (2003) 1.64
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res (2005) 1.59
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proc Natl Acad Sci U S A (2009) 1.52
The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities. J Biol Chem (2008) 1.52
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging (2005) 1.52
Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. Mol Cell Biol (2010) 1.50
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet (2008) 1.48
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Cockayne syndrome group B cellular and biochemical functions. Am J Hum Genet (2003) 1.46
DNA unwinding step-size of E. coli RecBCD helicase determined from single turnover chemical quenched-flow kinetic studies. J Mol Biol (2002) 1.44
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells (2008) 1.43
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci (2006) 1.42
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress. FASEB J (2003) 1.38
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol (2003) 1.37
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis (2003) 1.37
RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem (2005) 1.36
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem (2004) 1.36
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity. PLoS Biol (2007) 1.36
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. EMBO J (2010) 1.36
The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging. Mech Ageing Dev (2008) 1.36
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem (2011) 1.35
Junction of RecQ helicase biochemistry and human disease. J Biol Chem (2004) 1.34
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology (2008) 1.34
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res (2006) 1.34
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene (2004) 1.33
Localization of proteins bound to a replication origin of human DNA along the cell cycle. EMBO J (2003) 1.33
The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life. Mech Ageing Dev (2003) 1.33
Cobalt(II)-Nitronyl Nitroxide Chains as Molecular Magnetic Nanowires The financial support of Italian MURST and CNR and of Brazilian CNPq and FUJB is acknowledged. The support from the European Community through the TMR program 3MD (contract no ERB4061PL97-0197) is also acknowledged. Angew Chem Int Ed Engl (2001) 1.32
Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) (2008) 1.31
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress. Mol Cell Biol (2005) 1.31
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. Nucleic Acids Res (2006) 1.30
Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. FASEB J (2002) 1.27
Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) (2008) 1.27
WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem (2003) 1.27
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res (2006) 1.26
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J (2010) 1.25
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B. Oncogene (2002) 1.24
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol (2003) 1.23
Pathways and functions of the Werner syndrome protein. Mech Ageing Dev (2005) 1.23
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. J Biol Chem (2002) 1.22
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus. Nucleic Acids Res (2002) 1.22
A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092. J Cell Sci (2002) 1.21
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein. DNA Repair (Amst) (2002) 1.21
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. Aging Cell (2011) 1.20
RecQ helicases: multiple structures for multiple functions? HFSP J (2009) 1.20
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. J Biol Chem (2003) 1.19
Mitochondrial DNA repair and association with aging--an update. Exp Gerontol (2010) 1.19
Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice. DNA Repair (Amst) (2008) 1.19
Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc Natl Acad Sci U S A (2011) 1.19
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair (Amst) (2007) 1.19
Direct and indirect roles of RECQL4 in modulating base excision repair capacity. Hum Mol Genet (2009) 1.18
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. DNA Repair (Amst) (2009) 1.18
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates. Nucleic Acids Res (2007) 1.18
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. DNA Repair (Amst) (2010) 1.16
Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A. J Biol Chem (2002) 1.16
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res (2002) 1.16
Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Cancer Res (2006) 1.15
The involvement of human RECQL4 in DNA double-strand break repair. Aging Cell (2010) 1.15
Werner protein stimulates topoisomerase I DNA relaxation activity. Cancer Res (2003) 1.15
Regulation of WRN helicase activity in human base excision repair. J Biol Chem (2004) 1.15
The mitochondrial transcription factor A functions in mitochondrial base excision repair. DNA Repair (Amst) (2010) 1.14
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. J Biol Chem (2009) 1.12
One-dimensional supramolecular organization of single-molecule magnets. J Am Chem Soc (2007) 1.11