Published in Methods Enzymol on January 01, 2006
Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J (2009) 1.87
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci (2009) 1.52
Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene (2008) 1.27
Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells. J Biol Chem (2009) 1.23
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem (2009) 1.10
TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene (2010) 1.06
TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway. Cell Signal (2011) 1.03
Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA. J Biol Chem (2008) 1.01
Rho GTPase regulation by miRNAs and covalent modifications. Trends Cell Biol (2012) 0.90
Coupled local translation and degradation regulate growth cone collapse. Nat Commun (2015) 0.90
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. PLoS One (2012) 0.85
Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS Biol (2013) 0.84
The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. Genes Dev (2013) 0.83
The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. J Biol Chem (2013) 0.83
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton. Oncogene (2010) 0.82
Up-regulation of Smurf1 after spinal cord injury in adult rats. J Mol Histol (2013) 0.80
The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation. Cell Div (2010) 0.79
The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells. Small GTPases (2015) 0.78
Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia. Am J Pathol (2010) 0.77
Androgens regulate SMAD ubiquitination regulatory factor-1 expression and prostate cancer cell invasion. Prostate (2015) 0.75
Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα. Sci Rep (2016) 0.75
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (2005) 4.70
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol (2005) 4.48
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell (2012) 4.29
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (2004) 3.73
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature (2012) 3.44
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell (2008) 2.85
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell (2009) 2.79
On the origin of new genes in Drosophila. Genome Res (2008) 2.69
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
SVA elements are nonautonomous retrotransposons that cause disease in humans. Am J Hum Genet (2003) 2.55
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
A mouse model of human L1 retrotransposition. Nat Genet (2002) 2.39
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol (2007) 2.24
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome. Nat Biotechnol (2012) 2.14
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Tissue-specific alternative splicing remodels protein-protein interaction networks. Mol Cell (2012) 2.08
Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform. J Biol Chem (2003) 2.03
Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays (2005) 1.95
The disparate role of BMP in stem cell biology. Oncogene (2005) 1.92
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (2005) 1.88
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell (2012) 1.84
Subcortical origins of human and monkey neocortical interneurons. Nat Neurosci (2013) 1.78
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol (2008) 1.76
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell (2012) 1.72
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain. Cell Res (2011) 1.67
Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun (2009) 1.60
Evidence consistent with human L1 retrotransposition in maternal meiosis I. Am J Hum Genet (2002) 1.56
Irreversible electroporation therapy in the liver: longitudinal efficacy studies in a rat model of hepatocellular carcinoma. Cancer Res (2010) 1.56
TBestDB: a taxonomically broad database of expressed sequence tags (ESTs). Nucleic Acids Res (2007) 1.55
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
TGF-beta and the Smad signal transduction pathway. Biochem Cell Biol (2002) 1.51
An important role for RUNX3 in human L1 transcription and retrotransposition. Nucleic Acids Res (2003) 1.51
Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem (2005) 1.47
Impacts of cytogenetic categories in the Revised International Prognostic Scoring System on the prognosis of primary myelodysplastic syndromes: results of a single-center study. Leuk Lymphoma (2011) 1.45
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. PLoS One (2012) 1.44
Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila. PLoS Genet (2007) 1.42
Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci (2011) 1.41
Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Curr Biol (2007) 1.40
Enhancement of p53 gene transfer efficiency in hepatic tumor mediated by transferrin receptor through trans-arterial delivery. Cancer Biol Ther (2007) 1.40
A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. PLoS Genet (2010) 1.35
Wettability and surface free energy of graphene films. Langmuir (2009) 1.34
Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Genes Dev (2012) 1.33
Lipid metabolism and dynamics during phagocytosis. Curr Opin Cell Biol (2006) 1.32
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem (2004) 1.31
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A (2009) 1.29
Micropatterned mammalian cells exhibit phenotype-specific left-right asymmetry. Proc Natl Acad Sci U S A (2011) 1.26
Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation. Cancer Res (2006) 1.25
Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol (2011) 1.23
Complete genome sequence of a Vero cell-adapted isolate of porcine epidemic diarrhea virus in eastern China. J Virol (2012) 1.21
Modeling a macrocyclic bis[spirodiepoxide] strategy to erythronolide A. Org Lett (2009) 1.21
Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. J Clin Invest (2013) 1.20
FGDP: functional genomics data pipeline for automated, multiple microarray data analyses. Bioinformatics (2004) 1.19
Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness. PLoS One (2011) 1.19
Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell (2008) 1.19
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation. Cancer Res (2009) 1.18
Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer. Biochem Biophys Res Commun (2013) 1.17
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci U S A (2013) 1.16
Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer. Hepatology (2013) 1.15
Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep (2013) 1.15
GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol Cell Biol (2003) 1.15
The interleukin-1beta gene is transcribed from a poised promoter architecture in monocytes. J Biol Chem (2006) 1.14
GOBASE: an organelle genome database. Nucleic Acids Res (2008) 1.14
Intracellular membrane localization of pseudomonas ExoS and Yersinia YopE in mammalian cells. J Biol Chem (2003) 1.14
An empirical EEG analysis in brain death diagnosis for adults. Cogn Neurodyn (2008) 1.14
A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14
Three-dimensional ordered ZnO/Cu2O nanoheterojunctions for efficient metal-oxide solar cells. ACS Appl Mater Interfaces (2015) 1.12
Regulation of Par6 by extracellular signals. Curr Opin Cell Biol (2006) 1.12
CD137 promotes proliferation and survival of human B cells. J Immunol (2009) 1.12