Published in J Biol Chem on February 13, 2006
Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem (2008) 2.44
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev (2008) 1.90
Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3'-OH monoribonucleotide. J Biol Chem (2008) 1.36
Characterization of Agrobacterium tumefaciens DNA ligases C and D. Nucleic Acids Res (2007) 1.29
Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily. Proc Natl Acad Sci U S A (2010) 1.13
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol (2012) 1.10
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochem Cell Biol (2013) 1.09
Gap filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA end-binding Ku protein. J Biol Chem (2009) 1.05
Deinococcus radiodurans RNA ligase exemplifies a novel ligase clade with a distinctive N-terminal module that is important for 5'-PO4 nick sealing and ligase adenylylation but dispensable for phosphodiester formation at an adenylylated nick. Nucleic Acids Res (2007) 0.96
Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry (2012) 0.95
Multiple Ku orthologues mediate DNA non-homologous end-joining in the free-living form and during chronic infection of Sinorhizobium meliloti. Mol Microbiol (2007) 0.86
Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation. Nucleic Acids Res (2014) 0.86
Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation. J Biol Chem (2012) 0.85
Solution NMR studies of Chlorella virus DNA ligase-adenylate. J Mol Biol (2009) 0.84
Distinctive effects of domain deletions on the manganese-dependent DNA polymerase and DNA phosphorylase activities of Mycobacterium smegmatis polynucleotide phosphorylase. Biochemistry (2013) 0.83
DNA ligase C1 mediates the LigD-independent nonhomologous end-joining pathway of Mycobacterium smegmatis. J Bacteriol (2014) 0.83
Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Nucleic Acids Res (2011) 0.82
Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc Natl Acad Sci U S A (2015) 0.82
Structural insights to the metal specificity of an archaeal member of the LigD 3'-phosphoesterase DNA repair enzyme family. Nucleic Acids Res (2011) 0.81
Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. Infect Immun (2014) 0.78
RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria. J Bacteriol (2015) 0.78
Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences. J Mol Biol (2010) 0.78
Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallogr D Biol Crystallogr (2014) 0.77
Magnesium-induced nucleophile activation in the guanylyltransferase mRNA capping enzyme. Biochemistry (2012) 0.76
Identification of a conserved 5'-dRP lyase activity in bacterial DNA repair ligase D and its potential role in base excision repair. Nucleic Acids Res (2016) 0.76
Biochemical and Structural Characterisation of DNA Ligases from Bacteria and Archaea. Biosci Rep (2016) 0.75
Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74
A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q Rev Biophys (2008) 3.50
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct (2004) 3.37
Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell (2003) 3.00
DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol (2007) 2.96
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature (2005) 2.91
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79
Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling. Nat Struct Mol Biol (2006) 2.73
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
All tangled up: how cells direct, manage and exploit topoisomerase function. Nat Rev Mol Cell Biol (2011) 2.66
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25
Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II. Mol Cell (2003) 2.22
Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science (2007) 2.10
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. J Exp Med (2005) 2.10
The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol (2005) 2.08
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell (2009) 2.05
Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol (2003) 2.02
Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection. J Exp Med (2008) 2.02
Structure and mechanism of RNA ligase. Structure (2004) 2.00
The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation. EMBO J (2002) 1.98
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep (2013) 1.96
Bacterial DNA repair by non-homologous end joining. Nat Rev Microbiol (2007) 1.94
Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains. Proc Natl Acad Sci U S A (2002) 1.93
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev (2008) 1.90
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90
Deciphering the RNA polymerase II CTD code in fission yeast. Mol Cell (2011) 1.89
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nat Struct Mol Biol (2005) 1.86
What messenger RNA capping tells us about eukaryotic evolution. Nat Rev Mol Cell Biol (2002) 1.82
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell (2013) 1.82
RtcB is the RNA ligase component of an Escherichia coli RNA repair operon. J Biol Chem (2011) 1.82
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80
Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol (2002) 1.77
Portability and fidelity of RNA-repair systems. Proc Natl Acad Sci U S A (2004) 1.76
Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine. Structure (2005) 1.74
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. J Synchrotron Radiat (2004) 1.70
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70
RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell (2006) 1.66
Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence. J Clin Invest (2006) 1.66
A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65
Structural insights to how mammalian capping enzyme reads the CTD code. Mol Cell (2011) 1.64
Structure and mechanism of mRNA cap (guanine-N7) methyltransferase. Mol Cell (2004) 1.64
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64
RNA repair: an antidote to cytotoxic eukaryal RNA damage. Mol Cell (2008) 1.64
Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat Struct Mol Biol (2007) 1.63
Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions. J Biol Chem (2011) 1.60
Genetic and biochemical analysis of the functional domains of yeast tRNA ligase. J Biol Chem (2003) 1.60
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem (2001) 1.59
Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5. J Biol Chem (2002) 1.59
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell (2006) 1.58
Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell (2005) 1.57
A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo. PLoS Pathog (2011) 1.56
DNA stretching by bacterial initiators promotes replication origin opening. Nature (2011) 1.55
Biochemical and genetic analysis of the four DNA ligases of mycobacteria. J Biol Chem (2004) 1.54
Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme. EMBO J (2002) 1.54
RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J Biol Chem (2011) 1.53
RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates. Proc Natl Acad Sci U S A (2012) 1.51
Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators. Cell (2008) 1.51
Novel 3'-ribonuclease and 3'-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D. J Biol Chem (2005) 1.50
Mutational analysis of bacteriophage T4 RNA ligase 1. Different functional groups are required for the nucleotidyl transfer and phosphodiester bond formation steps of the ligation reaction. J Biol Chem (2003) 1.50
Mutational analysis defines the 5'-kinase and 3'-phosphatase active sites of T4 polynucleotide kinase. Nucleic Acids Res (2002) 1.50
RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. J Biol Chem (2004) 1.49
Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A (2006) 1.48
Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Mol Cell (2007) 1.48
An end-healing enzyme from Clostridium thermocellum with 5' kinase, 2',3' phosphatase, and adenylyltransferase activities. RNA (2005) 1.48
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A (2003) 1.44
Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis. Nature (2005) 1.44
The nuts and bolts of ring-translocase structure and mechanism. Curr Opin Struct Biol (2011) 1.44
Tat stimulates cotranscriptional capping of HIV mRNA. Mol Cell (2002) 1.43
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. J Bacteriol (2007) 1.42
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42
Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A (2010) 1.41
A large fraction of unclassified variants of the mismatch repair genes MLH1 and MSH2 is associated with splicing defects. Hum Mutat (2008) 1.41
Structure-function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homolog. Nucleic Acids Res (2006) 1.39
How an RNA ligase discriminates RNA versus DNA damage. Mol Cell (2004) 1.39
AdnAB: a new DSB-resecting motor-nuclease from mycobacteria. Genes Dev (2009) 1.36
Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3'-OH monoribonucleotide. J Biol Chem (2008) 1.36
A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II. Mol Cell (2004) 1.35
Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct Biol (2006) 1.34
A poxvirus-like type IB topoisomerase family in bacteria. Proc Natl Acad Sci U S A (2002) 1.31
Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis. J Biol Chem (2003) 1.31