Published in Nat Rev Mol Cell Biol on November 23, 2011
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell (2015) 2.35
Transcription-dependent dynamic supercoiling is a short-range genomic force. Nat Struct Mol Biol (2013) 2.07
Topoisomerases facilitate transcription of long genes linked to autism. Nature (2013) 1.93
Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression. Nat Cell Biol (2016) 1.78
Doxorubicin enhances nucleosome turnover around promoters. Curr Biol (2013) 1.58
DNA topoisomerase 1α promotes transcriptional silencing of transposable elements through DNA methylation and histone lysine 9 dimethylation in Arabidopsis. PLoS Genet (2014) 1.41
Ribonucleotides in DNA: origins, repair and consequences. DNA Repair (Amst) (2014) 1.38
Topoisomerase-mediated chromosomal break repair: an emerging player in many games. Nat Rev Cancer (2015) 1.15
Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci (2014) 1.11
Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria. PLoS Genet (2014) 1.08
Nonhomologous end joining: a good solution for bad ends. DNA Repair (Amst) (2014) 1.08
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability. Nat Rev Mol Cell Biol (2016) 1.05
Topoisomerase II and leukemia. Ann N Y Acad Sci (2014) 1.04
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection. Mol Cell (2016) 1.02
Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry (2012) 1.02
Topoisomerase assays. Curr Protoc Pharmacol (2012) 0.99
The role of DNA bending in type IIA topoisomerase function. Nucleic Acids Res (2013) 0.98
The MukB-ParC interaction affects the intramolecular, not intermolecular, activities of topoisomerase IV. J Biol Chem (2013) 0.98
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents. Int J Environ Res Public Health (2012) 0.97
Quantitative interactome analysis reveals a chemoresistant edgotype. Nat Commun (2015) 0.96
MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol (2016) 0.93
Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I. Nucleic Acids Res (2015) 0.93
Single-molecule nanometry for biological physics. Rep Prog Phys (2012) 0.93
DNA replication and homologous recombination factors: acting together to maintain genome stability. Chromosoma (2013) 0.92
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. Nucleic Acids Res (2013) 0.92
Bacterial Chromosome Organization and Segregation. Annu Rev Cell Dev Biol (2015) 0.91
Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons. Phytochem Rev (2014) 0.91
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nat Commun (2015) 0.89
Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways. Nucleic Acids Res (2012) 0.88
Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother (2015) 0.87
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport. Nucleic Acids Res (2013) 0.87
Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. PLoS One (2013) 0.86
Termination of DNA replication forks: "Breaking up is hard to do". Nucleus (2015) 0.86
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin. Nat Commun (2015) 0.84
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. Chem Res Toxicol (2014) 0.84
The GyrA-box determines the geometry of DNA bound to gyrase and couples DNA binding to the nucleotide cycle. Nucleic Acids Res (2012) 0.83
Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. J Biol Chem (2013) 0.83
H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule Experiments. Biophys J (2015) 0.83
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors. Medchemcomm (2013) 0.83
Distinct regions of the Escherichia coli ParC C-terminal domain are required for substrate discrimination by topoisomerase IV. J Mol Biol (2013) 0.83
Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy. Oncotarget (2016) 0.82
A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition. J Mol Biol (2014) 0.82
The Localization and Action of Topoisomerase IV in Escherichia coli Chromosome Segregation Is Coordinated by the SMC Complex, MukBEF. Cell Rep (2015) 0.82
TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres. Cell Cycle (2014) 0.82
DNA secondary structure at chromosomal fragile sites in human disease. Curr Genomics (2015) 0.82
The logic of DNA replication in double-stranded DNA viruses: insights from global analysis of viral genomes. Nucleic Acids Res (2016) 0.81
Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry (2014) 0.81
Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation. Nat Commun (2013) 0.81
The Dynamic Interplay Between DNA Topoisomerases and DNA Topology. Biophys Rev (2016) 0.81
Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling. Nucleic Acids Res (2012) 0.81
Variola type IB DNA topoisomerase: DNA binding and supercoil unwinding using engineered DNA minicircles. Biochemistry (2014) 0.81
An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent. Mar Drugs (2014) 0.81
Real-time detection of DNA topological changes with a fluorescently labeled cruciform. Nucleic Acids Res (2013) 0.81
Fragments of the bacterial toxin microcin B17 as gyrase poisons. PLoS One (2013) 0.81
Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry (2014) 0.80
Generation of supercoils in nicked and gapped DNA drives DNA unknotting and postreplicative decatenation. Nucleic Acids Res (2015) 0.80
STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage. PLoS One (2013) 0.80
Studies of bacterial topoisomerases I and III at the single-molecule level. Biochem Soc Trans (2013) 0.80
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases. Chem Res Toxicol (2013) 0.80
Large-scale reduction of the Bacillus subtilis genome: Consequences for the transcriptional network, resource allocation, and metabolism. Genome Res (2016) 0.80
Direct regulation of topoisomerase activity by a nucleoid-associated protein. Nucleic Acids Res (2014) 0.80
Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold. J Mol Biol (2015) 0.79
Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics. Future Med Chem (2015) 0.79
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis. Cell Death Differ (2013) 0.79
DNA topoisomerases participate in fragility of the oncogene RET. PLoS One (2013) 0.79
Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies. Nucleic Acids Res (2012) 0.78
Topoisomerase II regulates the maintenance of DNA methylation. J Biol Chem (2014) 0.78
Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I. Gene (2013) 0.78
A highly processive topoisomerase I: studies at the single-molecule level. Nucleic Acids Res (2014) 0.78
DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana. J Biol Chem (2015) 0.78
Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS One (2016) 0.78
TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol (2017) 0.77
The loading of condensin in the context of chromatin. Curr Genet (2016) 0.77
Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment. Nucleic Acids Res (2014) 0.77
Genome maintenance in the context of 4D chromatin condensation. Cell Mol Life Sci (2016) 0.77
High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia. Br J Cancer (2012) 0.77
DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin. J Biol Chem (2015) 0.77
Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα. Chem Res Toxicol (2016) 0.77
Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V. J Biol Chem (2014) 0.77
Investigating direct interaction between Escherichia coli topoisomerase I and RecA. Gene (2016) 0.77
EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells. Sci Rep (2015) 0.77
DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases. Sci Rep (2014) 0.77
Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Sci Rep (2015) 0.77
TOPOISOMERASE 6B is involved in chromatin remodelling associated with control of carbon partitioning into secondary metabolites and cell walls, and epidermal morphogenesis in Arabidopsis. J Exp Bot (2014) 0.77
Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens. J Virol (2016) 0.76
The Identification of a Novel Mutant Allele of topoisomerase II in Caenorhabditis elegans Reveals a Unique Role in Chromosome Segregation During Spermatogenesis. Genetics (2016) 0.76
Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex. Acta Crystallogr D Struct Biol (2016) 0.76
Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes Dev (2014) 0.76
Cell-cycle specific association of transcription factors and RNA polymerase ii with the human β-globin gene locus. J Cell Biochem (2013) 0.76
Inhibition of Zn(II) binding type IA topoisomerases by organomercury compounds and Hg(II). PLoS One (2015) 0.75
Toward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platform. PLoS One (2014) 0.75
Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site. Nucleic Acids Res (2016) 0.75
RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. Nat Commun (2016) 0.75
The tail that wags the dog: topoisomerase IV ParC C-terminal domain controls strand passage activity through multipartite topology-dependent interactions with DNA. J Mol Biol (2013) 0.75
Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. PLoS Genet (2016) 0.75
Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives. Bioorg Med Chem Lett (2016) 0.75
Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site. Biochim Biophys Acta (2015) 0.75
A capture approach for supercoiled plasmid DNA using a triplex-forming oligonucleotide. Nucleic Acids Res (2013) 0.75
Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes. Mol Cytogenet (2015) 0.75
Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents. Antimicrob Agents Chemother (2016) 0.75
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc Natl Acad Sci U S A (1976) 17.42
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature (2001) 16.89
Supercoiling of the DNA template during transcription. Proc Natl Acad Sci U S A (1987) 14.25
A common mechanism of cellular death induced by bactericidal antibiotics. Cell (2007) 12.92
Interaction between DNA and an Escherichia coli protein omega. J Mol Biol (1971) 11.03
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell (1997) 10.32
The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature (2003) 8.68
New topoisomerase essential for chromosome segregation in E. coli. Cell (1990) 7.19
An atypical topoisomerase II from Archaea with implications for meiotic recombination. Nature (1997) 7.06
An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay). Proc Natl Acad Sci U S A (1972) 6.75
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 6.71
DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08
DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc Natl Acad Sci U S A (1984) 5.75
Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73
DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Cell (1987) 5.52
A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell (1989) 5.52
At the heart of the chromosome: SMC proteins in action. Nat Rev Mol Cell Biol (2006) 5.45
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization. EMBO J (1984) 5.03
Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J Biol Chem (1993) 4.54
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature (2005) 4.53
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (1998) 4.51
Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Mol Cell (2000) 4.47
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J Mol Biol (1992) 4.13
A model for the mechanism of human topoisomerase I. Science (1998) 4.10
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli. Mol Syst Biol (2007) 3.98
The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication. Cell (1992) 3.88
DNA gyrase action involves the introduction of transient double-strand breaks into DNA. Proc Natl Acad Sci U S A (1980) 3.87
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell (1980) 3.83
The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A (2002) 3.71
Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature (2010) 3.58
Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature (1987) 3.56
Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis. EMBO J (1986) 3.53
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q Rev Biophys (2008) 3.50
Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II. Cell (1996) 3.39
A sign inversion mechanism for enzymatic supercoiling of DNA. Science (1979) 3.31
Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA. J Biol Chem (1980) 3.31
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science (1999) 3.29
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. Science (2005) 3.23
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges. EMBO J (2007) 3.22
Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1987) 3.21
DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage. Mol Cell Biol (1989) 3.15
ATP-dependent DNA topoisonmerase from D. melanogaster reversibly catenates duplex DNA rings. Cell (1980) 3.09
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays. Proc Natl Acad Sci U S A (2000) 3.08
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2. Nature (2010) 3.04
Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science (1995) 3.03
Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev (1995) 3.01
Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature (2005) 2.91
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell (2002) 2.85
Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Nucleic Acids Res (1998) 2.82
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79
Endoreplication: polyploidy with purpose. Genes Dev (2009) 2.78
Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science (2011) 2.73
Reverse gyrase--a topoisomerase which introduces positive superhelical turns into DNA. Nature (1984) 2.69
RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination. Mol Cell (1999) 2.64
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nat Cell Biol (2009) 2.60
The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. EMBO J (1996) 2.60
Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J Biol Chem (2000) 2.58
DNA topoisomerase I is involved in both repression and activation of transcription. Nature (1993) 2.53
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature (1994) 2.48
Structure of plectonemically supercoiled DNA. J Mol Biol (1990) 2.48
Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I. Nature (1996) 2.45
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases. Cell (1998) 2.40
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J (2005) 2.34
A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature (2009) 2.33
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev (2008) 2.29
A two-step scaffolding model for mitotic chromosome assembly. Dev Cell (2003) 2.27
Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior. Mol Biol Cell (2002) 2.26
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell (2008) 2.25
Identification of a potent decatenating enzyme from Escherichia coli. J Biol Chem (1988) 2.19
DNA topoisomerase IIbeta and neural development. Science (2000) 2.14
Yeast DNA topoisomerase II. An ATP-dependent type II topoisomerase that catalyzes the catenation, decatenation, unknotting, and relaxation of double-stranded DNA rings. J Biol Chem (1982) 2.09
The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol (2005) 2.08
Reverse gyrase: a helicase-like domain and a type I topoisomerase in the same polypeptide. Proc Natl Acad Sci U S A (1993) 2.04
The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase. EMBO J (1991) 2.04
Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis. Genome Dyn Stab (2008) 2.03
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev (2008) 1.97
Chromosome length influences replication-induced topological stress. Nature (2011) 1.95
Preferential relaxation of positively supercoiled DNA by E. coli topoisomerase IV in single-molecule and ensemble measurements. Genes Dev (2000) 1.94
Origin and evolution of DNA topoisomerases. Biochimie (2007) 1.94
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93
Decatenation activity of topoisomerase IV during oriC and pBR322 DNA replication in vitro. Proc Natl Acad Sci U S A (1993) 1.91
Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I. Proc Natl Acad Sci U S A (1995) 1.89
Mechanism of topology simplification by type II DNA topoisomerases. Proc Natl Acad Sci U S A (2001) 1.87
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration. Proc Natl Acad Sci U S A (2006) 1.83
The major architects of chromatin: architectural proteins in bacteria, archaea and eukaryotes. Crit Rev Biochem Mol Biol (2008) 1.80
Dual role of topoisomerase II in centromere resolution and aurora B activity. PLoS Biol (2008) 1.79
High positive supercoiling in vitro catalyzed by an ATP and polyethylene glycol-stimulated topoisomerase from Sulfolobus acidocaldarius. EMBO J (1985) 1.77
The structure of supercoiled intermediates in DNA replication. Cell (1998) 1.75
Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements. Mol Cell (2010) 1.74
S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function. J Biol Chem (2001) 1.72
Role of topoisomerase IIbeta in the expression of developmentally regulated genes. Mol Cell Biol (2006) 1.70
Conversion of DNA gyrase into a conventional type II topoisomerase. Proc Natl Acad Sci U S A (1996) 1.70
Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A (2006) 1.70
Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death. J Antimicrob Chemother (2010) 1.69
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J Biol Chem (2005) 1.68
Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2010) 1.68
Homeostatic regulation of supercoiling sensitivity coordinates transcription of the bacterial genome. EMBO Rep (2006) 1.66
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83
Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74
A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q Rev Biophys (2008) 3.50
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct (2004) 3.37
Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell (2003) 3.00
DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol (2007) 2.96
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79
Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling. Nat Struct Mol Biol (2006) 2.73
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58
Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25
Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science (2007) 2.10
The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol (2005) 2.08
Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol (2003) 2.02
The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation. EMBO J (2002) 1.98
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep (2013) 1.96
The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80
Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol (2002) 1.77
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. J Synchrotron Radiat (2004) 1.70
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70
A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65
Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell (2006) 1.58
Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell (2005) 1.57
DNA stretching by bacterial initiators promotes replication origin opening. Nature (2011) 1.55
Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators. Cell (2008) 1.51
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A (2003) 1.44
The nuts and bolts of ring-translocase structure and mechanism. Curr Opin Struct Biol (2011) 1.44
Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42
Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A (2010) 1.41
Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct Biol (2006) 1.34
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. J Biol Chem (2006) 1.31
AAA+ ATPases in the initiation of DNA replication. Crit Rev Biochem Mol Biol (2008) 1.29
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. Nat Struct Mol Biol (2009) 1.27
The MukF subunit of Escherichia coli condensin: architecture and functional relationship to kleisins. EMBO J (2005) 1.24
ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21
Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J (2003) 1.18
Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem (2006) 1.16
The bacterial DnaC helicase loader is a DnaB ring breaker. Cell (2013) 1.14
Regulation of bacterial priming and daughter strand synthesis through helicase-primase interactions. Nucleic Acids Res (2006) 1.13
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci (2007) 1.11
Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator. J Biol Chem (2010) 1.10
A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function. Nucleic Acids Res (2010) 1.09
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol (2012) 1.09
Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. J Biol Chem (2014) 1.08
Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus. Nucleic Acids Res (2004) 1.08
Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases. Mol Microbiol (2008) 1.07
Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol Cell (2006) 1.07
The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks. Nucleic Acids Res (2011) 1.07
A structural framework for replication origin opening by AAA+ initiation factors. Curr Opin Struct Biol (2012) 1.06
Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI. Structure (2005) 1.06
Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc Natl Acad Sci U S A (2009) 1.05
Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J Mol Biol (2008) 1.03
Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis. Proteins (2010) 1.03
Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nat Struct Mol Biol (2007) 1.02
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency. J Biol Chem (2012) 1.01
Contributions of folding cores to the thermostabilities of two ribonucleases H. Protein Sci (2002) 0.99
The role of DNA bending in type IIA topoisomerase function. Nucleic Acids Res (2013) 0.98
How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol (2008) 0.98
Molecular determinants of origin discrimination by Orc1 initiators in archaea. Nucleic Acids Res (2011) 0.98
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: I. A nonconserved acidic C-terminal tail modulates Escherichia coli gyrase activity. J Biol Chem (2012) 0.97
ATP binding controls distinct structural transitions of Escherichia coli DNA gyrase in complex with DNA. Nat Struct Mol Biol (2012) 0.97
Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (2005) 0.97
A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs. Proc Natl Acad Sci U S A (2010) 0.97
The crystal structure of the hinge domain of the Escherichia coli structural maintenance of chromosomes protein MukB. J Mol Biol (2009) 0.97
Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. PLoS One (2012) 0.96
Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein. Biochemistry (2009) 0.96
SnapShot: nucleic acid helicases and translocases. Cell (2008) 0.92
Two surfaces on the histone chaperone Rtt106 mediate histone binding, replication, and silencing. Proc Natl Acad Sci U S A (2011) 0.92
Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Proc Natl Acad Sci U S A (2009) 0.92
Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase. Biochemistry (2004) 0.91
Nanoscale protein assemblies from a circular permutant of the tobacco mosaic virus. Nano Lett (2010) 0.89
Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A. Protein Sci (2005) 0.89
Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Res (2006) 0.88
Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo. EMBO J (2013) 0.87
FASTDXL: a generalized screen to trap disulfide-stabilized complexes for use in structural studies. Structure (2007) 0.87
Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins (2010) 0.87
Emerging roles for plant topoisomerase VI. Chem Biol (2003) 0.86
Distinct regions of the Escherichia coli ParC C-terminal domain are required for substrate discrimination by topoisomerase IV. J Mol Biol (2013) 0.83
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. Elife (2013) 0.83
Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines. Nucleic Acids Res (2008) 0.83
Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design. ACS Chem Biol (2014) 0.83
Unraveling the early steps of prokaryotic replication. Curr Opin Struct Biol (2005) 0.83
Real-time detection of DNA topological changes with a fluorescently labeled cruciform. Nucleic Acids Res (2013) 0.81
Crystallization and X-ray structure determination of an RNA-dependent hexameric helicase. Methods Enzymol (2012) 0.79
False memory syndrome and therapist liability to third parties for emotional distress injuries arising from recovered memory therapy: a general prohibition on liability and a limited liability exception. Spec Law Dig Health Care Law (2002) 0.76