Published in Cell Signal on February 21, 2006
From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol (2008) 5.06
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol (2008) 1.57
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene (2009) 1.39
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul (2009) 1.28
RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex. Semin Cell Dev Biol (2014) 0.95
Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development. J Neurochem (2008) 0.91
Mechanisms of CDC-42 activation during contact-induced cell polarization. J Cell Sci (2013) 0.84
Establishment of epithelial polarity--GEF who's minding the GAP? J Cell Sci (2014) 0.84
Ect2/Pbl acts via Rho and polarity proteins to direct the assembly of an isotropic actomyosin cortex upon mitotic entry. Dev Cell (2015) 0.83
Up-regulation of ECT2 is associated with poor prognosis in gastric cancer patients. Int J Clin Exp Pathol (2014) 0.80
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer. Int J Biochem Cell Biol (2015) 0.78
Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. Cell Cycle (2015) 0.75
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev (2006) 5.59
The PAR-aPKC system: lessons in polarity. J Cell Sci (2006) 4.73
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol Cell (2003) 3.53
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci (2004) 2.47
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol (2004) 2.40
A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells. J Biol Chem (2002) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
Dissecting the role of Rho-mediated signaling in contractile ring formation. Mol Biol Cell (2005) 2.33
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol (2004) 2.19
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J Cell Sci (2002) 2.04
Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol (2013) 1.89
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev (2009) 1.82
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development (2006) 1.81
Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol (2010) 1.81
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res (2011) 1.55
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes Cells (2002) 1.54
ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol (2010) 1.54
Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. J Biol Chem (2003) 1.53
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene (2003) 1.50
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. J Biol Chem (2005) 1.50
The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta (2005) 1.49
Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci (2009) 1.45
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci (2006) 1.40
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn (2002) 1.39
Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J Biochem (2003) 1.38
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. Sci Signal (2010) 1.38
Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol Cell Biol (2006) 1.36
Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J Cell Sci (2002) 1.35
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35
Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. J Cell Sci (2006) 1.33
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics. Nat Cell Biol (2009) 1.31
Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. J Cell Biochem (2003) 1.29
Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes. FASEB J (2007) 1.29
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development (2006) 1.25
Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. Mol Cell Biol (2004) 1.24
Self-association of PAR-3-mediated by the conserved N-terminal domain contributes to the development of epithelial tight junctions. J Biol Chem (2003) 1.21
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Development (2002) 1.21
Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth. Front Biosci (2008) 1.21
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol (2005) 1.20
Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients. Oncol Rep (2006) 1.19
Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. J Biol Chem (2005) 1.19
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts. Mol Ther (2006) 1.17
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci U S A (2009) 1.15
The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Hum Pathol (2008) 1.14
Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann Neurol (2004) 1.14
PKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J Clin Invest (2005) 1.12
Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina. J Neurosci (2005) 1.12
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms. PLoS One (2009) 1.10
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. J Biol Chem (2007) 1.09
Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway. J Neurosci (2011) 1.07
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev (2011) 1.05
Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. J Cell Biol (2004) 1.03
KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells. Curr Biol (2011) 1.03
Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons. J Neurosci (2007) 1.01
Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo. Gene Expr Patterns (2005) 1.01
Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization. Exp Cell Res (2005) 1.01
The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. Genes Cells (2004) 1.00
Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. Hypertens Res (2003) 0.98
MgcRacGAP regulates cortical activity through RhoA during cytokinesis. Exp Cell Res (2004) 0.98
High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence. Ann Surg Oncol (2009) 0.96
Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex. Cancer Sci (2011) 0.95
The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction. J Immunol (2006) 0.95
Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. Mol Biol Cell (2003) 0.95
aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables. J Cell Sci (2008) 0.94
A cell polarity protein aPKClambda is required for eye lens formation and growth. Dev Biol (2009) 0.94
Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2. Nucleus (2012) 0.94
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex. Nucleic Acids Res (2010) 0.93
Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex. Genes Cells (2009) 0.93
The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. Retrovirology (2014) 0.92
Potential roles of the nucleotide exchange factor ECT2 and Cdc42 GTPase in spindle assembly in Xenopus egg cell-free extracts. J Cell Biochem (2003) 0.90
Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation. Biochem Biophys Res Commun (2002) 0.89
The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b. Biochem Biophys Res Commun (2009) 0.89
High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis. Cancer Sci (2012) 0.87
Role of PKC isoforms in glucose transport in 3T3-L1 adipocytes: insignificance of atypical PKC. Am J Physiol Endocrinol Metab (2002) 0.87
Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth. J Neurosci (2011) 0.87
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity. Proc Natl Acad Sci U S A (2013) 0.87
The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. J Cell Sci (2013) 0.86
Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol (2007) 0.86
The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis. Circ Res (2007) 0.86
Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Genes Cells (2002) 0.86
A novel role for hSMG-1 in stress granule formation. Mol Cell Biol (2011) 0.86
Expression and localisation of apical junctional complex proteins in lens epithelial cells. Exp Eye Res (2008) 0.84
Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages. Biochem Biophys Res Commun (2006) 0.84
Regulation of transformed state by calpastatin via PKCepsilon in NIH3T3 mouse fibroblasts. Biochem Biophys Res Commun (2002) 0.84
The KIBRA-aPKC connection: A potential regulator of membrane trafficking and cell polarity. Commun Integr Biol (2012) 0.83
TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner. Cell Signal (2005) 0.83
PAR-1/MARK: a kinase essential for maintaining the dynamic state of microtubules. Cell Struct Funct (2011) 0.82
Involvement of PKC betaII in anti-proliferating action of a new antitumor compound gnidimacrin. Int J Cancer (2003) 0.82
aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region. Biochem Biophys Res Commun (2008) 0.82
Protein kinase C epsilon phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone. FEBS J (2007) 0.82
Phosphoinositide binding by par-3 involved in par-3 localization. Cell Struct Funct (2011) 0.81
Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway. Biochem Biophys Res Commun (2012) 0.81
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization. Am J Physiol Gastrointest Liver Physiol (2004) 0.81
Analysis of nonsense-mediated mRNA decay by monitoring mRNA half-lives in mammalian cells. Cold Spring Harb Protoc (2010) 0.81