Published in Am J Physiol Cell Physiol on February 22, 2006
Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol (2009) 9.87
Collective migration of an epithelial monolayer in response to a model wound. Proc Natl Acad Sci U S A (2007) 4.35
Velocity fields in a collectively migrating epithelium. Biophys J (2010) 1.90
Plithotaxis and emergent dynamics in collective cellular migration. Trends Cell Biol (2011) 1.79
Emerging modes of collective cell migration induced by geometrical constraints. Proc Natl Acad Sci U S A (2012) 1.69
Physical model of the dynamic instability in an expanding cell culture. Biophys J (2010) 1.45
Cell crawling mediates collective cell migration to close undamaged epithelial gaps. Proc Natl Acad Sci U S A (2012) 1.31
Crawling cells can close wounds without purse strings or signaling. PLoS Comput Biol (2011) 1.26
A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. BMC Cancer (2008) 1.21
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med (2008) 1.14
Spatial constraints control cell proliferation in tissues. Proc Natl Acad Sci U S A (2014) 1.08
Traction forces during collective cell motion. HFSP J (2009) 1.08
Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression. PLoS One (2013) 1.08
Stochastic collective movement of cells and fingering morphology: no maverick cells. Biophys J (2009) 1.05
Boundary crossing in epithelial wound healing. Proc Natl Acad Sci U S A (2010) 1.02
Established and novel methods of interrogating two-dimensional cell migration. Integr Biol (Camb) (2012) 1.00
'White wave' analysis of epithelial scratch wound healing reveals how cells mobilise back from the leading edge in a myosin-II-dependent fashion. J Cell Sci (2011) 0.98
Mechanisms of epithelial wound detection. Trends Cell Biol (2015) 0.96
Leader cell positioning drives wound-directed collective migration in TGFβ-stimulated epithelial sheets. Mol Biol Cell (2014) 0.94
Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells. J Biol Chem (2010) 0.91
Planar cell polarity signaling in collective cell movements during morphogenesis and disease. Curr Genomics (2012) 0.91
A quantitative comet infection assay for influenza virus. J Virol Methods (2011) 0.88
Single cell gene expression analysis in injury-induced collective cell migration. Integr Biol (Camb) (2014) 0.87
Tracking monotonically advancing boundaries in image sequences using graph cuts and recursive kernel shape priors. IEEE Trans Med Imaging (2011) 0.86
Flow and diffusion in channel-guided cell migration. Biophys J (2014) 0.85
Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements. BMC Res Notes (2009) 0.85
A fast and accessible methodology for micro-patterning cells on standard culture substrates using Parafilm™ inserts. PLoS One (2011) 0.84
In vitro electrical-stimulated wound-healing chip for studying electric field-assisted wound-healing process. Biomicrofluidics (2012) 0.83
Gap geometry dictates epithelial closure efficiency. Nat Commun (2015) 0.83
Tension, free space, and cell damage in a microfluidic wound healing assay. PLoS One (2011) 0.82
Cellular Contraction and Polarization Drive Collective Cellular Motion. Biophys J (2016) 0.81
A mathematical model of intercellular signaling during epithelial wound healing. J Theor Biol (2010) 0.79
Simulation of lung alveolar epithelial wound healing in vitro. J R Soc Interface (2010) 0.79
Mechanical induction of an epithelial cell chymase associated with wound edge migration. J Biol Chem (2008) 0.79
On fundamental cellular processes for emergence of collective epithelial movement. Biol Open (2013) 0.78
A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation. Sci Signal (2015) 0.78
Free edges in epithelia as cues for motility. Cell Adh Migr (2011) 0.78
Influence of individual cell motility on the 2D front roughness dynamics of tumour cell colonies. J Biol Phys (2014) 0.77
Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement. Sci Rep (2016) 0.76
Mechanics of epithelial tissues during gap closure. Curr Opin Cell Biol (2016) 0.76
Data set for comparison of cellular dynamics between human AAVS1 locus-modified and wild-type cells. Data Brief (2016) 0.75
Clustering and jamming in epithelial-mesenchymal co-cultures. Soft Matter (2016) 0.75
Local mechanical stimulation of Mardin-Darby canine kidney cell sheets on temperature-responsive hydrogel. Int J Mol Sci (2012) 0.75
Mechanobiology of collective cell behaviours. Nat Rev Mol Cell Biol (2017) 0.75
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet (2006) 4.68
Redox-dependent downregulation of Rho by Rac. Nat Cell Biol (2003) 4.46
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell (2004) 4.23
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol (2007) 3.68
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol (2004) 3.46
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends Cell Biol (2003) 2.85
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
Shadow enhancers foster robustness of Drosophila gastrulation. Curr Biol (2010) 2.63
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest (2009) 2.53
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature (2007) 2.43
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Bistability and oscillations in the Huang-Ferrell model of MAPK signaling. PLoS Comput Biol (2007) 1.93
An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol (2011) 1.91
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med (2012) 1.82
Differential modification of Ras proteins by ubiquitination. Mol Cell (2006) 1.80
Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo. Proc Natl Acad Sci U S A (2011) 1.80
Quantitative models of developmental pattern formation. Dev Cell (2006) 1.71
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
Modeling the bicoid gradient: diffusion and reversible nuclear trapping of a stable protein. Dev Biol (2007) 1.67
Nuclear trapping shapes the terminal gradient in the Drosophila embryo. Curr Biol (2008) 1.63
Homogenization of boundary conditions for surfaces with regular arrays of traps. J Chem Phys (2006) 1.63
Dynamics of the Dorsal morphogen gradient. Proc Natl Acad Sci U S A (2009) 1.58
Quantifying the Gurken morphogen gradient in Drosophila oogenesis. Dev Cell (2006) 1.58
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol (2003) 1.52
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
Boundary homogenization for trapping by patchy surfaces. J Chem Phys (2004) 1.50
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology (2006) 1.48
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev (2003) 1.48
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
Local accumulation times for source, diffusion, and degradation models in two and three dimensions. J Chem Phys (2013) 1.40
Stochastic model of autocrine and paracrine signals in cell culture assays. Biophys J (2003) 1.39
Three-dimensional epithelial morphogenesis in the developing Drosophila egg. Dev Cell (2013) 1.37
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol (2009) 1.37
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res (2003) 1.35
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proc Natl Acad Sci U S A (2002) 1.33
A combinatorial code for pattern formation in Drosophila oogenesis. Dev Cell (2008) 1.33
The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A (2002) 1.32
Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature (2004) 1.30
MAPK substrate competition integrates patterning signals in the Drosophila embryo. Curr Biol (2010) 1.30
The Capicua repressor--a general sensor of RTK signaling in development and disease. J Cell Sci (2012) 1.29
Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem (2008) 1.29
Drosophila eggshell is patterned by sequential action of feedforward and feedback loops. Development (2007) 1.28
Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr Biol (2010) 1.27
Substrate-dependent control of MAPK phosphorylation in vivo. Mol Syst Biol (2011) 1.26
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun (2012) 1.26
Ligand accumulation in autocrine cell cultures. Biophys J (2005) 1.25
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res (2004) 1.23
The two hats of SOS. Sci STKE (2002) 1.22
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22
VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Res (2012) 1.21
Structure of the G60A mutant of Ras: implications for the dominant negative effect. J Biol Chem (2005) 1.21
Why are proteins charged? Networks of charge-charge interactions in proteins measured by charge ladders and capillary electrophoresis. Angew Chem Int Ed Engl (2006) 1.20
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A (2005) 1.20
Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. Methods Enzymol (2006) 1.19
Discrete models of autocrine cell communication in epithelial layers. Biophys J (2003) 1.16
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Res (2005) 1.13
Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure (2003) 1.12
Gene regulation by MAPK substrate competition. Dev Cell (2011) 1.12
Long-range signal transmission in autocrine relays. Biophys J (2003) 1.11
Spatial regulation of EGFR signaling by Sprouty2. Curr Biol (2007) 1.09
Pattern formation by a moving morphogen source. Phys Biol (2011) 1.07
EZH2 couples pancreatic regeneration to neoplastic progression. Genes Dev (2012) 1.07
Multiscale modeling of diffusion in the early Drosophila embryo. Proc Natl Acad Sci U S A (2010) 1.07
Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. Biol Blood Marrow Transplant (2002) 1.05
Ligand trapping in epithelial layers and cell cultures. Biophys Chem (2004) 1.05
Temporal dynamics, spatial range, and transcriptional interpretation of the Dorsal morphogen gradient. Curr Opin Genet Dev (2012) 1.04
Signaling gradients in cascades of two-state reaction-diffusion systems. Proc Natl Acad Sci U S A (2009) 1.04
Regulation of sprouty stability by Mnk1-dependent phosphorylation. Mol Cell Biol (2006) 1.03
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood (2009) 1.03
Pattern formation by graded and uniform signals in the early Drosophila embryo. Biophys J (2012) 1.03
Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A (2012) 1.02
How long does it take to establish a morphogen gradient? Biophys J (2010) 1.02
Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol (2010) 1.02
Quantitative analysis of the GAL4/UAS system in Drosophila oogenesis. Genesis (2006) 1.02
Kinetics of gene derepression by ERK signaling. Proc Natl Acad Sci U S A (2013) 1.02
Computational analysis of EGFR inhibition by Argos. Dev Biol (2005) 1.01
Time and length scales of autocrine signals in three dimensions. Biophys J (2007) 1.01
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol (2002) 0.98
Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol Biol (2002) 0.98
Allosteric gating of Son of sevenless activity by the histone domain. Proc Natl Acad Sci U S A (2010) 0.98
Microfluidic trap array for massively parallel imaging of Drosophila embryos. Nat Protoc (2013) 0.98
Formation of morphogen gradients: local accumulation time. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 0.97
Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis. Development (2009) 0.96
Torso RTK controls Capicua degradation by changing its subcellular localization. Development (2012) 0.95
Signaling endosomes: seeing is believing. Curr Opin Cell Biol (2010) 0.95
Pattern formation by dynamically interacting network motifs. Proc Natl Acad Sci U S A (2009) 0.95
Transcriptional interpretation of the EGF receptor signaling gradient. Proc Natl Acad Sci U S A (2012) 0.94
ERK as a model for systems biology of enzyme kinetics in cells. Curr Biol (2013) 0.94