Published in Structure on December 01, 2003
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22
Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc Natl Acad Sci U S A (2005) 1.20
The Histone Database: a comprehensive resource for histones and histone fold-containing proteins. Proteins (2006) 1.05
Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives. Genes Cancer (2011) 1.04
The Histone Database: an integrated resource for histones and histone fold-containing proteins. Database (Oxford) (2011) 1.04
Allosteric gating of Son of sevenless activity by the histone domain. Proc Natl Acad Sci U S A (2010) 0.98
Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1. Mol Biol Cell (2006) 0.95
Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells. Front Immunol (2013) 0.95
Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations. Mol Syst Biol (2014) 0.86
Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers. J Biol Chem (2009) 0.81
In silico functional characterization of a double histone fold domain from the Heliothis zea virus 1. BMC Bioinformatics (2005) 0.80
Identification and in silico analysis of a new group of double-histone fold-containing proteins. J Mol Model (2005) 0.78
Conservation of the three-dimensional structure in non-homologous or unrelated proteins. Hum Genomics (2012) 0.78
Release of Plasmodium sporozoites requires proteins with histone-fold dimerization domains. Nat Commun (2016) 0.75
Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains. Biophys Physicobiol (2016) 0.75
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 13.03
The conformational plasticity of protein kinases. Cell (2002) 11.21
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature (2006) 5.81
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet (2006) 4.68
Redox-dependent downregulation of Rho by Rac. Nat Cell Biol (2003) 4.46
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature (2004) 4.37
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell (2004) 4.23
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res (2002) 4.19
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol (2007) 3.68
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol (2004) 3.46
A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell (2007) 2.68
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. Cell (2012) 2.67
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A (2009) 2.55
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest (2009) 2.53
Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell (2013) 2.49
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature (2007) 2.43
Structure of a sliding clamp on DNA. Cell (2008) 2.42
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell (2011) 2.35
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases. Protein Sci (2005) 2.32
Architecture and membrane interactions of the EGF receptor. Cell (2013) 2.29
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A (2008) 2.18
Role of boundary conditions in an experimental model of epithelial wound healing. Am J Physiol Cell Physiol (2006) 2.01
The structure, regulation, and function of ZAP-70. Immunol Rev (2009) 2.01
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res (2006) 1.98
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell (2006) 1.94
An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol (2011) 1.91
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure (2007) 1.87
Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med (2012) 1.82
Differential modification of Ras proteins by ubiquitination. Mol Cell (2006) 1.80
Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics. Sci Transl Med (2012) 1.80
Clamp loaders and sliding clamps. Curr Opin Struct Biol (2002) 1.77
Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol (2002) 1.74
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell (2009) 1.72
Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70
Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res (2009) 1.64
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
How a DNA polymerase clamp loader opens a sliding clamp. Science (2011) 1.56
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol (2003) 1.52
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol (2006) 1.49
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology (2006) 1.48
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev (2003) 1.48
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
Probing the function of heme distortion in the H-NOX family. ACS Chem Biol (2008) 1.42
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J (2006) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci (2003) 1.39
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol (2009) 1.37
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res (2003) 1.35
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res (2002) 1.34
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proc Natl Acad Sci U S A (2002) 1.33
Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C. J Biol Chem (2006) 1.32
The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A (2002) 1.32
Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem (2008) 1.29
DNA polymerase clamp loaders and DNA recognition. FEBS Lett (2005) 1.28
Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen. Proc Natl Acad Sci U S A (2005) 1.27
Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr Biol (2010) 1.27
Regulation of the catalytic activity of the EGF receptor. Curr Opin Struct Biol (2011) 1.26
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun (2012) 1.26
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. BMC Struct Biol (2008) 1.26
Clamp loaders and replication initiation. Curr Opin Struct Biol (2006) 1.25
Analysis of the role of PCNA-DNA contacts during clamp loading. BMC Struct Biol (2010) 1.25
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res (2004) 1.23
The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. J Biol Chem (2006) 1.22
The two hats of SOS. Sci STKE (2002) 1.22
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A (2010) 1.22