Published in Curr Biol on November 07, 2006
Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell (2009) 3.47
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol (2007) 2.05
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Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res (2008) 1.43
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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun (2012) 1.26
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol (2012) 1.25
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Ras nanoclusters: combining digital and analog signaling. Cell Cycle (2007) 1.21
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Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2. Mol Cell Biol (2008) 1.03
RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol (2015) 1.03
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Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal (2013) 0.98
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Expressions and clinical significances of c-MET, p-MET and E2f-1 in human gastric carcinoma. BMC Res Notes (2014) 0.86
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Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proc Natl Acad Sci U S A (2013) 0.82
CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1. J Cell Biol (2011) 0.79
The human Rgr oncogene is overexpressed in T-cell malignancies and induces transformation by acting as a GEF for Ras and Ral. Oncogene (2011) 0.78
An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development. Mol Cell Biol (2007) 0.78
Negative feedback self-regulation contributes to robust and high-fidelity transmembrane signal transduction. J R Soc Interface (2013) 0.77
Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes. Proc Natl Acad Sci U S A (2016) 0.77
One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nat Struct Mol Biol (2016) 0.76
Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate. Nat Commun (2017) 0.75
Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs. Oncogene (2016) 0.75
A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife (2017) 0.75
The experiences of a biochemist in the evolving world of G protein-dependent signaling. Cell Signal (2017) 0.75
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 13.03
The conformational plasticity of protein kinases. Cell (2002) 11.21
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell (2006) 10.28
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol (2005) 6.49
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell (2003) 5.44
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet (2006) 4.68
Redox-dependent downregulation of Rho by Rac. Nat Cell Biol (2003) 4.46
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature (2004) 4.37
MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell (2004) 4.23
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res (2002) 4.19
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell (2012) 4.16
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol (2007) 3.68
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell (2003) 3.66
Imaging hematopoietic precursor division in real time. Cell Stem Cell (2007) 3.62
A myristoyl/phosphotyrosine switch regulates c-Abl. Cell (2003) 3.48
Modulation of signalling by Sprouty: a developing story. Nat Rev Mol Cell Biol (2004) 3.46
A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol (2006) 3.40
Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature (2010) 3.20
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell (2005) 3.08
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biol (2008) 2.99
Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science (2010) 2.93
Membrane-dependent signal integration by the Ras activator Son of sevenless. Nat Struct Mol Biol (2008) 2.82
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature (2007) 2.78
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell (2007) 2.68
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization. Cell (2012) 2.67
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem (2004) 2.66
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell (2011) 2.58
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci U S A (2009) 2.55
In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest (2009) 2.53
Structural basis for calcium sensing by GCaMP2. Structure (2008) 2.52
Conformational coupling across the plasma membrane in activation of the EGF receptor. Cell (2013) 2.49
Neural response to reward anticipation under risk is nonlinear in probabilities. J Neurosci (2009) 2.45
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature (2007) 2.43
Structure of a sliding clamp on DNA. Cell (2008) 2.42
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41
Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell (2004) 2.38
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Mol Cell (2011) 2.35
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases. Protein Sci (2005) 2.32
Architecture and membrane interactions of the EGF receptor. Cell (2013) 2.29
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell (2006) 2.28
A conserved protonation-dependent switch controls drug binding in the Abl kinase. Proc Natl Acad Sci U S A (2008) 2.18
A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. PLoS Biol (2011) 2.05
Structural bases of unphosphorylated STAT1 association and receptor binding. Mol Cell (2005) 2.05
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology (2002) 2.05
Role of boundary conditions in an experimental model of epithelial wound healing. Am J Physiol Cell Physiol (2006) 2.01
The structure, regulation, and function of ZAP-70. Immunol Rev (2009) 2.01
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res (2006) 1.98
Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell (2003) 1.98
Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell (2006) 1.94
Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biol (2011) 1.93
Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A. Proc Natl Acad Sci U S A (2011) 1.93
Exact controllability of complex networks. Nat Commun (2013) 1.93
An orthosteric inhibitor of the Ras-Sos interaction. Nat Chem Biol (2011) 1.91
Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc Natl Acad Sci U S A (2009) 1.91
c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure (2007) 1.87
Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. Cell (2011) 1.87
Molecular mechanisms in signal transduction at the membrane. Nat Struct Mol Biol (2010) 1.86
MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med (2012) 1.82
Differential modification of Ras proteins by ubiquitination. Mol Cell (2006) 1.80
Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure (2009) 1.79
Clamp loaders and sliding clamps. Curr Opin Struct Biol (2002) 1.77
AtPID: Arabidopsis thaliana protein interactome database--an integrative platform for plant systems biology. Nucleic Acids Res (2007) 1.76
Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol (2002) 1.74
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell (2009) 1.72
Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes. J Cell Biol (2002) 1.69
Structural basis for the recognition of c-Src by its inactivator Csk. Cell (2008) 1.66
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res (2009) 1.64
Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res (2004) 1.58
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell (2010) 1.58
A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci U S A (2006) 1.57
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell (2011) 1.56
How a DNA polymerase clamp loader opens a sliding clamp. Science (2011) 1.56
Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. J Virol (2009) 1.55
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol (2003) 1.52
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro. Sci China Life Sci (2014) 1.51
Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci (2005) 1.50
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A (2013) 1.49
Protein-protein interactions in the allosteric regulation of protein kinases. Curr Opin Struct Biol (2006) 1.49