Published in Science on February 24, 2006
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
Long noncoding RNAs: functional surprises from the RNA world. Genes Dev (2009) 9.14
Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc (2006) 7.29
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18
The genetic signatures of noncoding RNAs. PLoS Genet (2009) 6.72
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res (2008) 6.43
Noncoding transcription by RNA polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes. Cell (2008) 5.78
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol (2013) 4.57
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Genome-wide views of chromatin structure. Annu Rev Biochem (2009) 3.89
Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell (2006) 3.76
Noncoding RNA in development. Mamm Genome (2008) 3.42
Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36
The rise of regulatory RNA. Nat Rev Genet (2014) 3.02
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol (2011) 2.56
RNA traffic control of chromatin complexes. Curr Opin Genet Dev (2010) 2.49
A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy. Cell (2012) 2.29
Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster. RNA (2006) 2.26
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex. PLoS Genet (2007) 2.12
eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci. Mol Cell (2013) 2.12
Retracted The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin. Mol Cell (2011) 2.07
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. Genome Biol (2007) 2.03
Noncoding RNA and Polycomb recruitment. RNA (2013) 2.00
A major epigenetic programming mechanism guided by piRNAs. Dev Cell (2013) 1.89
Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Mol Cell Biol (2007) 1.84
Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome. Genome Biol Evol (2012) 1.69
RNA at the steering wheel. Genome Biol (2006) 1.57
Xist and the order of silencing. EMBO Rep (2007) 1.55
Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog Neurobiol (2008) 1.53
Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J (2007) 1.46
Regulation of transcription by long noncoding RNAs. Annu Rev Genet (2014) 1.43
The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs. Cold Spring Harb Perspect Biol (2011) 1.43
Regeneration, repair and remembering identity: the three Rs of Hox gene expression. Trends Cell Biol (2009) 1.35
Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region. Mol Cell Biol (2008) 1.31
Functions of noncoding RNAs in neural development and neurological diseases. Mol Neurobiol (2011) 1.27
A systematic approach to identify functional motifs within vertebrate developmental enhancers. Dev Biol (2009) 1.26
Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica. PLoS Pathog (2006) 1.26
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell (2009) 1.23
From bacteria to humans, chromatin to elongation, and activation to repression: The expanding roles of noncoding RNAs in regulating transcription. Crit Rev Biochem Mol Biol (2009) 1.23
Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci. Nucleic Acids Res (2012) 1.17
Profiling RE1/REST-mediated histone modifications in the human genome. Genome Biol (2009) 1.16
Epigenetic boundaries of tumour suppressor gene promoters: the CTCF connection and its role in carcinogenesis. J Cell Mol Med (2006) 1.11
Analysis of the Tribolium homeotic complex: insights into mechanisms constraining insect Hox clusters. Dev Genes Evol (2008) 1.09
A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region. Mol Cell Biol (2007) 1.09
Non-coding RNAs in retinal development. Int J Mol Sci (2012) 1.04
Genomic landscape of developing male germ cells. Birth Defects Res C Embryo Today (2009) 1.00
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. Nat Struct Mol Biol (2010) 1.00
LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression. Nucleic Acids Res (2014) 0.96
Non-coding RNA: a new frontier in regulatory biology. Natl Sci Rev (2014) 0.95
Long non-coding RNAs in colorectal cancer. Oncotarget (2016) 0.92
Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol (2013) 0.92
RNA-mediated gene activation. Epigenetics (2013) 0.92
Emerging epigenetic mechanisms of long non-coding RNAs. Neuroscience (2013) 0.91
In situ dissection of a Polycomb response element in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 0.89
Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? Front Cell Infect Microbiol (2014) 0.88
Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis. Cancers (Basel) (2015) 0.87
Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle. Cell Mol Life Sci (2010) 0.86
Shaping the oligodendrocyte identity by epigenetic control. Epigenetics (2010) 0.86
Strategies to identify long noncoding RNAs involved in gene regulation. Cell Biosci (2012) 0.85
In vivo analysis of Drosophila SU(Z)12 function. Mol Genet Genomics (2007) 0.83
A novel molecular mechanism in human genetic disease: a DNA repeat-derived lncRNA. RNA Biol (2012) 0.82
Chromatin immunoprecipitation from human embryonic stem cells. J Vis Exp (2008) 0.82
ALS and FTD: an epigenetic perspective. Acta Neuropathol (2016) 0.81
CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA. J Cell Biochem (2010) 0.81
Panning for Long Noncoding RNAs. Biomolecules (2013) 0.81
Comparison of ultra-conserved elements in drosophilids and vertebrates. PLoS One (2013) 0.81
Genome-wide identification and developmental expression profiling of long noncoding RNAs during Drosophila metamorphosis. Sci Rep (2016) 0.80
Chromosomal organization at the level of gene complexes. Cell Mol Life Sci (2010) 0.80
The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy. Cell Res (2012) 0.78
An interactive network of long non-coding RNAs facilitates the Drosophila sex determination decision. Biochim Biophys Acta (2014) 0.78
Enrichment of mRNA-like noncoding RNAs in the divergence of Drosophila males. Mol Biol Evol (2010) 0.78
Regulatory long non-coding RNAs and neuronal disorders. Physiol Behav (2010) 0.77
RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex. PLoS One (2013) 0.77
Intergenic Polycomb target sites are dynamically marked by non-coding transcription during lineage commitment. RNA Biol (2012) 0.76
Meiotic, cryptic, and stable unannotated transcripts: noncoding RNAs add to the epigenetic tool box controlling meiotic development. Proc Natl Acad Sci U S A (2011) 0.75
Letter to the editor: Clothes Do Not Make the Man: Well-favored Figures are Game-changers in the Biomedical Publication. J Korean Med Sci (2015) 0.75
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. BMC Genomics (2015) 0.75
Findings of Research Misconduct. Fed Regist (2017) 0.75
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (2013) 6.34
Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol (2007) 4.96
Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med (2008) 3.13
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell (2009) 2.98
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol (2009) 2.76
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Nucleic Acids Res (2007) 2.74
CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol (2007) 2.61
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature (2006) 2.40
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J (2010) 2.35
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol (2007) 2.20
A multifunctional human Argonaute2-specific monoclonal antibody. RNA (2008) 2.17
Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med (2008) 2.15
Retracted The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin. Mol Cell (2011) 2.07
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science (2012) 2.05
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J Biol Chem (2010) 2.00
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med (2004) 1.97
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe (2010) 1.91
CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol (2009) 1.83
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathol (2013) 1.82
The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nat Cell Biol (2008) 1.82
A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J (2003) 1.78
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem (2009) 1.76
RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. J Neurosci (2010) 1.76
CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood (2009) 1.73
Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol (2005) 1.73
Subunit stoichiometry of the CNG channel of rod photoreceptors. Neuron (2002) 1.71
Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol (2005) 1.69
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol (2008) 1.63
Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. J Cell Sci (2003) 1.62
Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation. Blood (2010) 1.61
Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. J Pathol (2002) 1.60
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. J Exp Med (2011) 1.60
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathol (2013) 1.59
A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell (2013) 1.59
Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood (2005) 1.56
CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci U S A (2007) 1.56
A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem (2010) 1.55
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation. EMBO J (2012) 1.55
Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Invest (2016) 1.52
Automatic registration of portal images and volumetric CT for patient positioning in radiation therapy. Med Image Anal (2005) 1.51
Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. RNA (2010) 1.51
C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration. Acta Neuropathol (2014) 1.48
Thymic T cell development and progenitor localization depend on CCR7. J Exp Med (2004) 1.48
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J (2008) 1.47
Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells. Blood (2006) 1.46
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J Biol Chem (2007) 1.46
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J (2012) 1.45
Mouse phenotyping. Methods (2010) 1.43
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. Am J Pathol (2002) 1.42
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol (2009) 1.42
Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med (2009) 1.41
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2007) 1.41
Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Nucleic Acids Res (2006) 1.41
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol (2007) 1.39
Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23-33. J Immunol (2016) 1.39
Retracted TAF1 activates transcription by phosphorylation of serine 33 in histone H2B. Science (2004) 1.39
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A (2012) 1.39
Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. J Biol Chem (2012) 1.37
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. J Biol Chem (2014) 1.37
Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J Immunol (2002) 1.34
Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol (2010) 1.33
Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract. Virchows Arch (2005) 1.33
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res (2011) 1.32
Type 3a and type 3b OFF cone bipolar cells provide for the alternative rod pathway in the mouse retina. J Comp Neurol (2007) 1.31
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol Cell Biol (2007) 1.31
Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70. J Transl Med (2007) 1.30
Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J Clin Invest (2011) 1.30
Defects in 18 S or 28 S rRNA processing activate the p53 pathway. J Biol Chem (2010) 1.30
ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. Invest Ophthalmol Vis Sci (2009) 1.30
Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism. J Immunol (2009) 1.30
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Oncogene (2005) 1.30
Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeleton. J Cell Sci (2007) 1.29
HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Eur J Neurosci (2003) 1.28
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol (2008) 1.26
Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects. RNA (2011) 1.26
Systemic first-line phenotyping. Methods Mol Biol (2009) 1.26
Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. Circulation (2005) 1.25
Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. Hum Mol Genet (2010) 1.25
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell (2013) 1.25
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiol Dis (2007) 1.25
Generalized multi-organ autoimmunity in CCR7-deficient mice. Eur J Immunol (2007) 1.23
Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A (2010) 1.21
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity (2013) 1.21
Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells (2007) 1.20
An atypical CNG channel activated by a single cGMP molecule controls sperm chemotaxis. Sci Signal (2009) 1.20
Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. J Neurosci (2013) 1.18
Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy. Int J Cancer (2008) 1.17
Df31 protein and snoRNAs maintain accessible higher-order structures of chromatin. Mol Cell (2012) 1.17
Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma. Mol Cancer Res (2011) 1.17
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J Biol Chem (2008) 1.17
Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization. RNA (2009) 1.17
Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. J Immunol (2009) 1.17
Intracellular localization map of human herpesvirus 8 proteins. J Virol (2007) 1.16