Published in J Cell Biol on July 30, 2007
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
The many facets of Notch ligands. Oncogene (2008) 2.57
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell (2009) 2.04
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42
Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev Cell (2012) 1.35
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. Sci Transl Med (2015) 1.33
The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol (2008) 1.24
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res (2012) 1.17
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A (2008) 1.13
Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn (2009) 1.13
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. Lab Invest (2009) 1.12
Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J (2014) 1.02
Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Dev Biol (2009) 0.99
EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma. Oncotarget (2014) 0.96
Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol (2009) 0.94
Distinct contextual roles for Notch signalling in skeletal muscle stem cells. BMC Dev Biol (2014) 0.94
O-fucosylation of DLL3 is required for its function during somitogenesis. PLoS One (2015) 0.93
Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development (2011) 0.93
Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling. J Neurosci (2013) 0.91
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
The mouse notches up another success: understanding the causes of human vertebral malformation. Mamm Genome (2011) 0.86
Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM. Development (2014) 0.85
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function. PLoS One (2014) 0.84
Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J (2017) 0.82
Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal. Front Oncol (2016) 0.80
Delta-like 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma. Int J Oncol (2013) 0.80
S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development. Mol Cell Biol (2014) 0.79
Cellular and molecular biology of small cell lung cancer: an overview. Transl Lung Cancer Res (2016) 0.79
Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife (2016) 0.78
An evolutionary-conserved function of mammalian notch family members as cell adhesion molecules. PLoS One (2014) 0.77
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet (2015) 0.76
Notch-Mediated Cell Adhesion. Biology (Basel) (2016) 0.76
Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone. BMC Med (2016) 0.75
Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination. BMC Genet (2015) 0.75
Targeting the seeds of small cell lung cancer. Ann Transl Med (2017) 0.75
Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1. Genetics (2016) 0.75
Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer. Cancer Res (2017) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Genetic transformation of Drosophila with transposable element vectors. Science (1982) 27.36
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell (2003) 4.30
Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis (2000) 3.71
Maintenance of somite borders in mice requires the Delta homologue DII1. Nature (1997) 3.44
Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol (1998) 2.75
A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr Biol (2001) 2.65
The roles of receptor and ligand endocytosis in regulating Notch signaling. Development (2005) 2.33
The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J (1987) 2.23
neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev Cell (2001) 2.22
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (2003) 2.21
Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr Biol (1997) 2.13
Golgi localization of glycosyltransferases: more questions than answers. Glycobiology (1997) 2.07
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development (2005) 2.06
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development (1997) 2.03
Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem (1999) 2.00
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet (1998) 1.96
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature (2005) 1.94
RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol (1997) 1.89
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol (2005) 1.88
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev (1996) 1.82
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res (2006) 1.77
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A (2006) 1.76
Delta-notch signaling and Drosophila cell fate choice. Dev Biol (1994) 1.74
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development (2002) 1.66
SnapShot: notch signaling pathway. Cell (2007) 1.63
The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway. Dev Biol (2001) 1.54
Ligand-induced signaling in the absence of furin processing of Notch1. Dev Biol (2001) 1.51
Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification. Dev Biol (2002) 1.47
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev Cell (2002) 1.44
An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila. Dev Biol (1997) 1.42
The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. Dev Cell (2006) 1.41
The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem (2002) 1.40
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J (2006) 1.39
Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev (2003) 1.29
The interplay between DSL proteins and ubiquitin ligases in Notch signaling. Development (2005) 1.28
Notch signaling in vertebrate development and disease. Mol Cell Neurosci (1997) 1.26
The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development (1991) 1.26
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev (2004) 1.17
Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Development (2004) 1.17
Comparative aspects of Notch signaling in lower and higher eukaryotes. Perspect Dev Neurobiol (1997) 1.12
Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech Dev (2005) 1.11
Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells. Biochem Biophys Res Commun (2006) 1.09
Wing disc development in the fly: the early stages. Curr Opin Genet Dev (2001) 1.08
Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. Biochem Biophys Res Commun (2000) 1.08
Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development (2004) 1.05
Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis (2004) 0.87
Genetic mechanisms of early neurogenesis in Drosophila melanogaster. J Physiol Paris (1994) 0.76
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (2013) 6.34
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol (2007) 4.96
Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18
Retracted Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax. Science (2006) 4.10
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52
Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell (2003) 3.15
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med (2008) 3.13
Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second. Opt Express (2010) 3.04
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell (2009) 2.98
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol (2009) 2.76
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Nucleic Acids Res (2007) 2.74
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol (2007) 2.61
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature (2006) 2.40
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J (2010) 2.35
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (2003) 2.21
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol (2007) 2.20
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet (2008) 2.19
A multifunctional human Argonaute2-specific monoclonal antibody. RNA (2008) 2.17
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17
Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med (2008) 2.15
Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell (2008) 2.12
A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell (2012) 2.08
DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood (2009) 2.07
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell (2006) 2.06
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science (2012) 2.05
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity (2008) 2.05
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J Biol Chem (2010) 2.00
Notch signaling in development and disease. Semin Cancer Biol (2004) 1.97
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med (2004) 1.97
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe (2010) 1.91
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (2005) 1.90
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3. Circ Res (2008) 1.90
Improved detection of prostate cancer using classification and regression tree analysis. J Clin Oncol (2005) 1.85
CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol (2009) 1.83
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathol (2013) 1.82
The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nat Cell Biol (2008) 1.82
A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J (2003) 1.78
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem (2009) 1.76
Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A (2006) 1.76
RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. J Neurosci (2010) 1.76
WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev (2004) 1.74
CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood (2009) 1.73
Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol (2005) 1.73
Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr Patterns (2002) 1.72
Subunit stoichiometry of the CNG channel of rod photoreceptors. Neuron (2002) 1.71
Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res (2006) 1.70
Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol (2005) 1.69
Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell (2011) 1.67
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development (2002) 1.66
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol (2008) 1.63
Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. J Cell Sci (2003) 1.62
Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation. Blood (2010) 1.61
Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development (2005) 1.61
Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat Neurosci (2006) 1.61
Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. J Pathol (2002) 1.60
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. J Exp Med (2011) 1.60
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathol (2013) 1.59
A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Dev Cell (2013) 1.59
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell (2007) 1.59
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation (2005) 1.57
Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood (2005) 1.56
CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci U S A (2007) 1.56
A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem (2010) 1.55
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation. EMBO J (2012) 1.55
Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res (2007) 1.54
Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Invest (2016) 1.52
Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. RNA (2010) 1.51
C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration. Acta Neuropathol (2014) 1.48
Thymic T cell development and progenitor localization depend on CCR7. J Exp Med (2004) 1.48
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J (2008) 1.47
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev (2004) 1.46
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J Biol Chem (2007) 1.46
Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells. Blood (2006) 1.46
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J (2012) 1.45
Long-term results of pancreas transplantation in patients older than 50 years. Transpl Int (2010) 1.44
Mouse phenotyping. Methods (2010) 1.43
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. Am J Pathol (2002) 1.42
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol (2009) 1.42
Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med (2009) 1.41
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2007) 1.41
The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. Dev Cell (2006) 1.41
Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Nucleic Acids Res (2006) 1.41