Possible pathogenesis of painful intervertebral disc degeneration.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMID 16508552)

Published in Spine (Phila Pa 1976) on March 01, 2006

Authors

Baogan Peng1, Jianhua Hao, Shuxun Hou, Wenwen Wu, Duyin Jiang, Xiaobing Fu, Yi Yang

Author Affiliations

1: Department of Orthopaedics, 304th hospital, Beijing, China. pengbaogan@163.com

Articles citing this

The role of macrophage phenotype in vascularization of tissue engineering scaffolds. Biomaterials (2014) 2.04

Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene (2008) 1.45

The role of the vertebral end plate in low back pain. Global Spine J (2013) 1.12

Fibroblast growth factor control of cartilage homeostasis. J Cell Biochem (2013) 1.05

Action of fibroblast growth factor-2 on the intervertebral disc. Arthritis Res Ther (2008) 1.01

Inflammatory mediators in intervertebral disk degeneration and discogenic pain. Global Spine J (2013) 0.95

Pathophysiology of degenerative disc disease. Asian Spine J (2009) 0.94

Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. Spine (Phila Pa 1976) (2011) 0.91

SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res (2008) 0.91

Diagnosis and surgical treatment of back pain originating from endplate. Eur Spine J (2009) 0.90

Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? Clin Orthop Relat Res (2015) 0.89

Pathophysiology, diagnosis, and treatment of discogenic low back pain. World J Orthop (2013) 0.88

Immune cascades in human intervertebral disc: the pros and cons. Int J Clin Exp Pathol (2013) 0.88

Macrophages modulate engineered human tissues for enhanced vascularization and healing. Ann Biomed Eng (2014) 0.86

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells. Spine (Phila Pa 1976) (2015) 0.84

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug. Spine J (2015) 0.83

Ex vivo observation of human intervertebral disc tissue and cells isolated from degenerated intervertebral discs. Eur Spine J (2012) 0.82

Sustained long-term RNA interference in nucleus pulposus cells in vivo mediated by unmodified small interfering RNA. Eur Spine J (2009) 0.82

TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration. Sci Rep (2015) 0.82

Cervical spondylosis and hypertension: a clinical study of 2 cases. Medicine (Baltimore) (2015) 0.81

Expression of soluble Fas and soluble FasL in human nucleus pulposus cells. Int J Clin Exp Pathol (2013) 0.81

Notochordal cells influence gene expression of inflammatory mediators of annulus fibrosus cells in proinflammatory cytokines stimulation. J Korean Neurosurg Soc (2010) 0.81

Low back pain associated with lumbar disc herniation: role of moderately degenerative disc and annulus fibrous tears. Int J Clin Exp Med (2015) 0.80

Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy. J Orthop Surg Res (2009) 0.80

Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Arthritis Rheum (2012) 0.80

Association between intervertebral disc degeneration and endplate perfusion studied by DCE-MRI. Eur Spine J (2014) 0.78

Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration. Stem Cells Int (2016) 0.77

Relationship between neovascularization and degenerative changes in herniated lumbar intervertebral discs. Eur Spine J (2013) 0.77

Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis. Sci Rep (2016) 0.77

Antibiotic penetration into rabbit nucleus pulposus with discitis. Eur J Orthop Surg Traumatol (2013) 0.76

Cell signaling pathways related to pain receptors in the degenerated disk. Global Spine J (2013) 0.75

Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration. J Interferon Cytokine Res (2015) 0.75

Matrix Degradative Enzymes and Their Inhibitors during Annular Inflammation: Initial Step of Symptomatic Intervertebral Disc Degeneration. J Korean Neurosurg Soc (2014) 0.75

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res (2017) 0.75

Development of a two-step protocol for culture expansion of human annulus fibrosus cells with TGF-β1 and FGF-2. Stem Cell Res Ther (2016) 0.75

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia. Stem Cell Reports (2016) 0.75

A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-β3-Loaded Nanoparticles for Nucleus Pulposus Regeneration. Stem Cells Int (2016) 0.75

Intervertebral discs from spinal nondeformity and deformity patients have different mechanical and matrix properties. Spine J (2013) 0.75

Articles by these authors

Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88

Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science (2009) 8.84

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79

Mesothelin variant 1 is released from tumor cells as a diagnostic marker. Cancer Epidemiol Biomarkers Prev (2006) 2.77

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75

Relay and control of abscisic acid signaling. Curr Opin Plant Biol (2003) 2.51

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21

Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining. Genome Res (2012) 2.12

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol (2011) 2.08

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07

Potential bridges for HIV infection to men who have sex with men in Guangzhou, China. AIDS Behav (2006) 2.06

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00

Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother (2012) 1.97

Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life (2007) 1.92

Alignment of optical maps. J Comput Biol (2006) 1.88

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus (2007) 1.78

Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer (2009) 1.78

MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76

BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. Cancer Res (2009) 1.72

Converting ceria polyhedral nanoparticles into single-crystal nanospheres. Science (2006) 1.70

Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. Am J Hum Genet (2008) 1.65

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62

Mapping hydration dynamics around a protein surface. Proc Natl Acad Sci U S A (2007) 1.61

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Diagnosis and management of pituitary abscess: experiences from 33 cases. Clin Endocrinol (Oxf) (2011) 1.55

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J Lipid Res (2009) 1.50

Computer-driven automated weaning reduces weaning duration in difficult-to-wean patients. Chin Med J (Engl) (2013) 1.48

The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J (2005) 1.48

Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab (2011) 1.47

A dammarane glycoside derived from ginsenoside Rb3. Chem Pharm Bull (Tokyo) (2005) 1.47

Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Res (2007) 1.45

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

Identification of sequence variants in genetic disease-causing genes using targeted next-generation sequencing. PLoS One (2011) 1.44

Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res (2003) 1.42

The influence of RAMP1 overexpression on CGRP-induced osteogenic differentiation in MG-63 cells in vitro: an experimental study. J Cell Biochem (2013) 1.42

Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology (2007) 1.41

Environmental impact of aquaculture and countermeasures to aquaculture pollution in China. Environ Sci Pollut Res Int (2007) 1.40

Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. J Biol Chem (2004) 1.39

PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med (2009) 1.39

Ex vivo immunotherapy for patients with benzene-induced aplastic anemia. J Hematother Stem Cell Res (2003) 1.38

Enhanced magnetic resonance imaging of Guillain-Barré syndrome. J Paediatr Child Health (2011) 1.38

Deep ultraviolet photoluminescence of water-soluble self-passivated graphene quantum dots. ACS Nano (2012) 1.37

Reconstruction with modular hemipelvic prostheses for periacetabular tumor. Clin Orthop Relat Res (2007) 1.35

Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization. Biomed Opt Express (2011) 1.35

Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res (2012) 1.33

Protein hydration dynamics and molecular mechanism of coupled water-protein fluctuations. J Am Chem Soc (2009) 1.33

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest (2012) 1.32

Difference in risk behaviors and STD prevalence between street-based and establishment-based FSWs in Guangdong Province, China. AIDS Behav (2012) 1.30

Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther (2007) 1.29

miR-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation. Cancer Res (2012) 1.29

Prevalence of HIV and STIs and associated risk factors among female sex workers in Guangdong Province, China. J Acquir Immune Defic Syndr (2010) 1.29

Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells. Wound Repair Regen (2009) 1.29

miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Res (2013) 1.27

Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function. Hum Mutat (2008) 1.27

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27

Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol (2010) 1.26

Myelin loss associated with neuroinflammation in hypertensive rats. Stroke (2012) 1.26

MFEprimer: multiple factor evaluation of the specificity of PCR primers. Bioinformatics (2008) 1.25

VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res (2011) 1.25

MFEprimer-2.0: a fast thermodynamics-based program for checking PCR primer specificity. Nucleic Acids Res (2012) 1.24

Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages. Cell Tissue Res (2006) 1.21

CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol (2006) 1.20

Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology (2006) 1.20

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development. Toxicol Lett (2008) 1.20

Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clin Cancer Res (2010) 1.20

Exceptional tunability of band energy in a compressively strained trilayer MoS2 sheet. ACS Nano (2013) 1.19

Stimuli responsive upconversion luminescence nanomaterials and films for various applications. Chem Soc Rev (2015) 1.19

Protein surface hydration mapped by site-specific mutations. Proc Natl Acad Sci U S A (2006) 1.18

Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One (2012) 1.17

A novel solid-state thermal rectifier based on reduced graphene oxide. Sci Rep (2012) 1.17

Disentangling the stigma of HIV/AIDS from the stigmas of drugs use, commercial sex and commercial blood donation - a factorial survey of medical students in China. BMC Public Health (2007) 1.16

A novel real-time PCR assay of microRNAs using S-Poly(T), a specific oligo(dT) reverse transcription primer with excellent sensitivity and specificity. PLoS One (2012) 1.16

The macro domain protein family: structure, functions, and their potential therapeutic implications. Mutat Res (2011) 1.15

Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. J Proteome Res (2009) 1.15

Naturally derived materials-based cell and drug delivery systems in skin regeneration. J Control Release (2009) 1.14

KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells (2010) 1.14

A proteogenomic analysis of Anopheles gambiae using high-resolution Fourier transform mass spectrometry. Genome Res (2011) 1.14

Long Noncoding RNAs: Insights from Biological Features and Functions to Diseases. Med Res Rev (2012) 1.13

Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance. Plant Cell (2008) 1.11

Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia. Int J Ophthalmol (2013) 1.11

Human myosin Vc is a low duty ratio, nonprocessive molecular motor. J Biol Chem (2008) 1.11

Outcome of conservative surgery for giant cell tumor of the sacrum. Spine (Phila Pa 1976) (2009) 1.11

Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates. Cancer Res (2010) 1.10

Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. Gastroenterology (2006) 1.10

Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology (2007) 1.10

Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins. Breast Cancer Res (2010) 1.09

Ultrafast solvation dynamics of human serum albumin: correlations with conformational transitions and site-selected recognition. J Phys Chem B (2006) 1.09

Stromal cell-derived factor-1 enhances wound healing through recruiting bone marrow-derived mesenchymal stem cells to the wound area and promoting neovascularization. Cells Tissues Organs (2012) 1.09

Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity. Diabetes (2012) 1.08

Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J Biol Chem (2009) 1.08

Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion. Chin J Traumatol (2006) 1.08

Neuroventilatory efficiency and extubation readiness in critically ill patients. Crit Care (2012) 1.08

Anti-aquaporin-4 antibody-seronegative NMO spectrum disorder with Baló's concentric lesions. Intern Med (2014) 1.07