Protein hydration dynamics and molecular mechanism of coupled water-protein fluctuations.

The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation. Curr Opin Struct Biol (2012) 1.37

On the binding affinity of macromolecular interactions: daring to ask why proteins interact. J R Soc Interface (2012) 1.16

Ultrafast solvation dynamics at binding and active sites of photolyases. Proc Natl Acad Sci U S A (2010) 1.16

Site-specific hydration dynamics in the nonpolar core of a molten globule by dynamic nuclear polarization of water. J Am Chem Soc (2011) 1.05

Mapping the hydration dynamics of ubiquitin. J Am Chem Soc (2011) 1.00

Mapping solvation dynamics at the function site of flavodoxin in three redox states. J Am Chem Soc (2010) 1.00

Photophysics of a Fluorescent Non-natural Amino Acid: p-Cyanophenylalanine. Chem Phys Lett (2010) 0.99

Long-range protein-water dynamics in hyperactive insect antifreeze proteins. Proc Natl Acad Sci U S A (2012) 0.97

Dynamics and mechanism of ultrafast water-protein interactions. Proc Natl Acad Sci U S A (2016) 0.90

Blind prediction of interfacial water positions in CAPRI. Proteins (2013) 0.90

Hydration dynamics at fluorinated protein surfaces. Proc Natl Acad Sci U S A (2010) 0.89

Validation of response function construction and probing heterogeneous protein hydration by intrinsic tryptophan. J Phys Chem B (2012) 0.89

Femtosecond conical intersection dynamics of tryptophan in proteins and validation of slowdown of hydration layer dynamics. J Am Chem Soc (2012) 0.84

Water Dynamics in the Hydration Shells of Biomolecules. Chem Rev (2017) 0.83

Solvation in protein (un)folding of melittin tetramer-monomer transition. Proc Natl Acad Sci U S A (2009) 0.81

Quenching Dynamics of Ultraviolet-Light Perception by UVR8 Photoreceptor. J Phys Chem Lett (2014) 0.81

Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents. J Proteome Res (2014) 0.81

Infrared and Fluorescence Assessment of Protein Dynamics: From Folding to Function. J Phys Chem B (2016) 0.80

Probing water density and dynamics in the chaperonin GroEL cavity. J Am Chem Soc (2014) 0.80

Dynamics and mechanisms of DNA repair by photolyase. Phys Chem Chem Phys (2015) 0.80

Weighted protein residue networks based on joint recurrences between residues. BMC Bioinformatics (2015) 0.79

Reconciling mediating and slaving roles of water in protein conformational dynamics. PLoS One (2013) 0.79

Changes of water hydrogen bond network with different externalities. Int J Mol Sci (2015) 0.78

A Native Threonine Coordinates Ordered Water to Tune Light-Oxygen-Voltage (LOV) Domain Photocycle Kinetics and Osmotic Stress Signaling in Trichoderma reesei ENVOY. J Biol Chem (2016) 0.78

Direct determination of resonance energy transfer in photolyase: structural alignment for the functional state. J Phys Chem A (2014) 0.77

Ultrafast water dynamics at the interface of the polymerase-DNA binding complex. Biochemistry (2014) 0.77

Molecular docking as a popular tool in drug design, an in silico travel. Adv Appl Bioinform Chem (2016) 0.76

Direct probing of solvent accessibility and mobility at the binding interface of polymerase (Dpo4)-DNA complex. J Phys Chem A (2013) 0.76

Cholesterol enhances surface water diffusion of phospholipid bilayers. J Chem Phys (2014) 0.76

Do guanidinium and tetrapropylammonium ions specifically interact with aromatic amino acid side chains? Proc Natl Acad Sci U S A (2017) 0.75

Hydrogen Bond Network of Water around Protein Investigated with Terahertz and Infrared Spectroscopy. Biophys J (2016) 0.75

Charge invariant protein-water relaxation in GB1 via ultrafast tryptophan fluorescence. J Am Chem Soc (2014) 0.75

Effect of the Solvent Temperatures on Dynamics of Serine Protease Proteinase K. Int J Mol Sci (2016) 0.75

ESR study of interfacial hydration layers of polypeptides in water-filled nanochannels and in vitrified bulk solvents. PLoS One (2013) 0.75

On the ability of molecular dynamics simulation and continuum electrostatics to treat interfacial water molecules in protein-protein complexes. Sci Rep (2016) 0.75

Structure of the ordered hydration of amino acids in proteins: analysis of crystal structures. Acta Crystallogr D Biol Crystallogr (2015) 0.75

Implementing electrostatic polarization cannot fill the gap between experimental and theoretical measurements for the ultrafast fluorescence decay of myoglobin. J Mol Model (2014) 0.75

Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88

Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science (2009) 8.84

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat Cell Biol (2002) 2.95

Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79

Mesothelin variant 1 is released from tumor cells as a diagnostic marker. Cancer Epidemiol Biomarkers Prev (2006) 2.77

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75

Relay and control of abscisic acid signaling. Curr Opin Plant Biol (2003) 2.51

Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol (2007) 2.40

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells. PLoS One (2012) 2.23

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21

Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining. Genome Res (2012) 2.12

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol (2011) 2.08

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07

Direct observation of thymine dimer repair in DNA by photolyase. Proc Natl Acad Sci U S A (2005) 2.01

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00

Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother (2012) 1.97

Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells. J Virol (2002) 1.93

Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life (2007) 1.92

Alignment of optical maps. J Comput Biol (2006) 1.88

Th9 cells promote antitumor immune responses in vivo. J Clin Invest (2012) 1.80

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus (2007) 1.78

Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer (2009) 1.78

MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76

Converting ceria polyhedral nanoparticles into single-crystal nanospheres. Science (2006) 1.70

Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. Am J Hum Genet (2008) 1.65

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62

Mapping hydration dynamics around a protein surface. Proc Natl Acad Sci U S A (2007) 1.61

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Ultrafast dynamics and anionic active states of the flavin cofactor in cryptochrome and photolyase. J Am Chem Soc (2008) 1.55

Diagnosis and management of pituitary abscess: experiences from 33 cases. Clin Endocrinol (Oxf) (2011) 1.55

Assessing moral distress in respiratory care practitioners. Crit Care Med (2006) 1.55

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J Lipid Res (2009) 1.50

Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther (2011) 1.50

Computer-driven automated weaning reduces weaning duration in difficult-to-wean patients. Chin Med J (Engl) (2013) 1.48

The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J (2005) 1.48

Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab (2011) 1.47

A dammarane glycoside derived from ginsenoside Rb3. Chem Pharm Bull (Tokyo) (2005) 1.47

Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase. Proc Natl Acad Sci U S A (2011) 1.45

Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Res (2007) 1.45

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

Identification of sequence variants in genetic disease-causing genes using targeted next-generation sequencing. PLoS One (2011) 1.44

Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res (2003) 1.42

Reaction mechanism of Drosophila cryptochrome. Proc Natl Acad Sci U S A (2010) 1.42

Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem (2007) 1.42

Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology (2007) 1.41

Environmental impact of aquaculture and countermeasures to aquaculture pollution in China. Environ Sci Pollut Res Int (2007) 1.40

Dynamics and mechanism of repair of ultraviolet-induced (6-4) photoproduct by photolyase. Nature (2010) 1.40

PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med (2009) 1.39

Enhanced magnetic resonance imaging of Guillain-Barré syndrome. J Paediatr Child Health (2011) 1.38

Ex vivo immunotherapy for patients with benzene-induced aplastic anemia. J Hematother Stem Cell Res (2003) 1.38

Reconstruction with modular hemipelvic prostheses for periacetabular tumor. Clin Orthop Relat Res (2007) 1.35

Possible pathogenesis of painful intervertebral disc degeneration. Spine (Phila Pa 1976) (2006) 1.35

Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization. Biomed Opt Express (2011) 1.35

Searching for a photocycle of the cryptochrome photoreceptors. Curr Opin Plant Biol (2010) 1.34

Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res (2012) 1.33

Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. Gynecol Oncol (2011) 1.33

Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16. Appl Environ Microbiol (2008) 1.33

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest (2012) 1.32

Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Circ Res (2011) 1.31

A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. J Biol Chem (2011) 1.30

Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther (2007) 1.29

miR-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation. Cancer Res (2012) 1.29

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem (2002) 1.28

miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Res (2013) 1.27

Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function. Hum Mutat (2008) 1.27

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27

Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol (2010) 1.26

Myelin loss associated with neuroinflammation in hypertensive rats. Stroke (2012) 1.26

MFEprimer: multiple factor evaluation of the specificity of PCR primers. Bioinformatics (2008) 1.25

VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res (2011) 1.25

Ultrafast dynamics of flavins in five redox states. J Am Chem Soc (2008) 1.25

MFEprimer-2.0: a fast thermodynamics-based program for checking PCR primer specificity. Nucleic Acids Res (2012) 1.24

CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol (2006) 1.20

Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology (2006) 1.20

Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clin Cancer Res (2010) 1.20

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development. Toxicol Lett (2008) 1.20

Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas. PLoS Genet (2013) 1.19

Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol (2004) 1.19

Hydration dynamics and time scales of coupled water-protein fluctuations. J Am Chem Soc (2007) 1.19

Protein surface hydration mapped by site-specific mutations. Proc Natl Acad Sci U S A (2006) 1.18

Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One (2012) 1.17