Published in Neurosurg Focus on May 15, 2007
Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis (2010) 1.90
Application of medical gases in the field of neurobiology. Med Gas Res (2011) 1.64
Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9. Stroke (2009) 1.56
Occludin: one protein, many forms. Mol Cell Biol (2011) 1.53
Blood-brain barrier pathophysiology in traumatic brain injury. Transl Stroke Res (2011) 1.45
Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke? Med Gas Res (2016) 1.42
Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab (2013) 1.41
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. J Neurosci (2012) 1.39
Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron (2014) 1.30
Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor. Virology (2009) 1.25
Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins. PLoS One (2011) 1.24
Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke. Front Neurol (2013) 1.23
Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress. J Neurochem (2009) 1.22
The blood-brain barrier in neurodegenerative disease: a rhetorical perspective. J Neurochem (2009) 1.20
Traumatic brain injury, neuroinflammation, and post-traumatic headaches. Headache (2013) 1.19
Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. J Neurochem (2009) 1.15
Drowning stars: reassessing the role of astrocytes in brain edema. Trends Neurosci (2014) 1.13
Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases. Exp Neurol (2010) 1.13
Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics (2011) 1.12
Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2011) 1.10
Targets of vascular protection in acute ischemic stroke differ in type 2 diabetes. Am J Physiol Heart Circ Physiol (2013) 1.07
Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model. Neuroscience (2010) 1.04
Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist (2010) 1.04
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage. PLoS One (2011) 1.03
Tobacco smoke: a critical etiological factor for vascular impairment at the blood-brain barrier. Brain Res (2009) 1.01
Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons. Neuroscience (2012) 1.01
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke. Med Gas Res (2011) 0.98
Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption. PLoS One (2013) 0.98
Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury. Am J Respir Cell Mol Biol (2010) 0.98
Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis? J Cereb Blood Flow Metab (2014) 0.97
Matrix metalloproteinases as therapeutic targets for stroke. Brain Res (2015) 0.97
Protection after stroke: cellular effectors of neurovascular unit integrity. Front Cell Neurosci (2014) 0.97
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke. Ann Neurol (2011) 0.95
Modulation of cell-cell junctional complexes by matrix metalloproteinases. J Dent Res (2012) 0.95
Neutrophil transmigration, focal adhesion kinase and endothelial barrier function. Microvasc Res (2011) 0.94
Blood cells and endothelial barrier function. Tissue Barriers (2015) 0.94
Blood-brain barrier dysfunction in disorders of the developing brain. Front Neurosci (2015) 0.92
Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice. Exp Neurol (2011) 0.90
Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia-ischemia. Neuroscience (2009) 0.89
Advances in stroke therapy. Drug Deliv Transl Res (2011) 0.88
Blood brain barrier and neuroinflammation are critical targets of IGF-1-mediated neuroprotection in stroke for middle-aged female rats. PLoS One (2014) 0.88
Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury. J Neuroinflammation (2009) 0.86
Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury. Acta Pharmacol Sin (2012) 0.86
Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. PLoS One (2012) 0.85
MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery. J Clin Neurosci (2010) 0.85
Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood-brain barrier integrity? Fluids Barriers CNS (2014) 0.84
Different expressions of AQP1, AQP4, eNOS, and VEGF proteins in ischemic versus non-ischemic cerebropathy in rats: potential roles of AQP1 and eNOS in hydrocephalic and vasogenic edema formation. Anat Cell Biol (2011) 0.84
Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke. Sci Rep (2015) 0.84
Blood-brain barrier in acute liver failure. Neurochem Int (2011) 0.83
Vascular protection to increase the safety of tissue plasminogen activator for stroke. Curr Pharm Des (2012) 0.83
Doxycycline treatment decreases morbidity and mortality of murine neurocysticercosis: evidence for reduction of apoptosis and matrix metalloproteinase activity. Am J Pathol (2009) 0.83
Effects of acupuncture at GV20 and ST36 on the expression of matrix metalloproteinase 2, aquaporin 4, and aquaporin 9 in rats subjected to cerebral ischemia/reperfusion injury. PLoS One (2014) 0.83
The role of substance p in ischaemic brain injury. Brain Sci (2013) 0.81
Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke. Front Cell Neurosci (2016) 0.81
Age-associated physiological and pathological changes at the blood-brain barrier: A review. J Cereb Blood Flow Metab (2016) 0.80
Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy. J Ocul Biol Dis Infor (2012) 0.79
Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice. Front Cell Neurosci (2015) 0.78
Inhibition of Src phosphorylation reduces damage to the blood-brain barrier following transient focal cerebral ischemia in rats. Int J Mol Med (2014) 0.78
Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Mediators Inflamm (2015) 0.78
Nuts 'n' guts: transport of food allergens across the intestinal epithelium. Asia Pac Allergy (2013) 0.78
Normobaric hyperoxia slows blood-brain barrier damage and expands the therapeutic time window for tissue-type plasminogen activator treatment in cerebral ischemia. Stroke (2015) 0.78
Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers. J Cereb Blood Flow Metab (2016) 0.77
The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage. Dis Markers (2015) 0.77
Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma (2016) 0.76
Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke. Toxicol Res (2013) 0.76
Candesartan attenuates ischemic brain edema and protects the blood-brain barrier integrity from ischemia/reperfusion injury in rats. Iran Biomed J (2014) 0.76
Protective effect of ginsenoside Rb1 on integrity of blood-brain barrier following cerebral ischemia. Exp Brain Res (2015) 0.76
Effects of novel semiselective matrix metalloproteinase inhibitors on ex vivo cardiac structure-function. J Cardiovasc Pharmacol (2009) 0.76
Redox Regulation of Transient Receptor Potential Channels in the Endothelium. Microcirculation (2016) 0.75
A possible molecular mechanism of hearing loss during cerebral ischemia in mice. Can J Physiol Pharmacol (2015) 0.75
Glucocorticoids in the management of peritumoral brain edema: a review of molecular mechanisms. Childs Nerv Syst (2016) 0.75
Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Mol Med Rep (2017) 0.75
Response to Letter Regarding Article, "Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke". Stroke (2016) 0.75
Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88
Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science (2009) 8.84
A validated regulatory network for Th17 cell specification. Cell (2012) 4.82
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79
Mesothelin variant 1 is released from tumor cells as a diagnostic marker. Cancer Epidemiol Biomarkers Prev (2006) 2.77
High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75
Relay and control of abscisic acid signaling. Curr Opin Plant Biol (2003) 2.51
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29
Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21
Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining. Genome Res (2012) 2.12
SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol (2011) 2.08
gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07
Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00
Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother (2012) 1.97
Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life (2007) 1.92
Alignment of optical maps. J Comput Biol (2006) 1.88
Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer (2009) 1.78
MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76
Converting ceria polyhedral nanoparticles into single-crystal nanospheres. Science (2006) 1.70
Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. Am J Hum Genet (2008) 1.65
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62
Mapping hydration dynamics around a protein surface. Proc Natl Acad Sci U S A (2007) 1.61
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58
Diagnosis and management of pituitary abscess: experiences from 33 cases. Clin Endocrinol (Oxf) (2011) 1.55
Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J Lipid Res (2009) 1.50
Computer-driven automated weaning reduces weaning duration in difficult-to-wean patients. Chin Med J (Engl) (2013) 1.48
The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J (2005) 1.48
Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab (2011) 1.47
A dammarane glycoside derived from ginsenoside Rb3. Chem Pharm Bull (Tokyo) (2005) 1.47
Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Res (2007) 1.45
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44
Identification of sequence variants in genetic disease-causing genes using targeted next-generation sequencing. PLoS One (2011) 1.44
Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res (2003) 1.42
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology (2007) 1.41
Environmental impact of aquaculture and countermeasures to aquaculture pollution in China. Environ Sci Pollut Res Int (2007) 1.40
PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med (2009) 1.39
Enhanced magnetic resonance imaging of Guillain-Barré syndrome. J Paediatr Child Health (2011) 1.38
Ex vivo immunotherapy for patients with benzene-induced aplastic anemia. J Hematother Stem Cell Res (2003) 1.38
Reconstruction with modular hemipelvic prostheses for periacetabular tumor. Clin Orthop Relat Res (2007) 1.35
Possible pathogenesis of painful intervertebral disc degeneration. Spine (Phila Pa 1976) (2006) 1.35
Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization. Biomed Opt Express (2011) 1.35
Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res (2012) 1.33
Protein hydration dynamics and molecular mechanism of coupled water-protein fluctuations. J Am Chem Soc (2009) 1.33
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest (2012) 1.32
Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther (2007) 1.29
miR-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation. Cancer Res (2012) 1.29
miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Res (2013) 1.27
Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function. Hum Mutat (2008) 1.27
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27
Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol (2010) 1.26
Myelin loss associated with neuroinflammation in hypertensive rats. Stroke (2012) 1.26
VTX-2337 is a novel TLR8 agonist that activates NK cells and augments ADCC. Clin Cancer Res (2011) 1.25
MFEprimer: multiple factor evaluation of the specificity of PCR primers. Bioinformatics (2008) 1.25
MFEprimer-2.0: a fast thermodynamics-based program for checking PCR primer specificity. Nucleic Acids Res (2012) 1.24
CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol (2006) 1.20
Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology (2006) 1.20
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development. Toxicol Lett (2008) 1.20
Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells. Clin Cancer Res (2010) 1.20
Protein surface hydration mapped by site-specific mutations. Proc Natl Acad Sci U S A (2006) 1.18
Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One (2012) 1.17
A novel solid-state thermal rectifier based on reduced graphene oxide. Sci Rep (2012) 1.17
Disentangling the stigma of HIV/AIDS from the stigmas of drugs use, commercial sex and commercial blood donation - a factorial survey of medical students in China. BMC Public Health (2007) 1.16
A novel real-time PCR assay of microRNAs using S-Poly(T), a specific oligo(dT) reverse transcription primer with excellent sensitivity and specificity. PLoS One (2012) 1.16
Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. J Proteome Res (2009) 1.15
A proteogenomic analysis of Anopheles gambiae using high-resolution Fourier transform mass spectrometry. Genome Res (2011) 1.14
KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells (2010) 1.14
Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance. Plant Cell (2008) 1.11
Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia. Int J Ophthalmol (2013) 1.11
Human myosin Vc is a low duty ratio, nonprocessive molecular motor. J Biol Chem (2008) 1.11
Outcome of conservative surgery for giant cell tumor of the sacrum. Spine (Phila Pa 1976) (2009) 1.11
Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. Gastroenterology (2006) 1.10
Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology (2007) 1.10
Ultrafast solvation dynamics of human serum albumin: correlations with conformational transitions and site-selected recognition. J Phys Chem B (2006) 1.09
Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion. Chin J Traumatol (2006) 1.08
Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J Biol Chem (2009) 1.08
Neuroventilatory efficiency and extubation readiness in critically ill patients. Crit Care (2012) 1.08
Comment and reply on: emerging role of Th22 and IL-22 in multiple sclerosis, an autoimmune disease in the central nervous system. Expert Opin Ther Targets (2013) 1.07
Anti-aquaporin-4 antibody-seronegative NMO spectrum disorder with Baló's concentric lesions. Intern Med (2014) 1.07
Graphene-on-paper sound source devices. ACS Nano (2011) 1.06
CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am J Physiol Lung Cell Mol Physiol (2005) 1.06
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab Invest (2010) 1.06
Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. J Immunol (2009) 1.05
Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators Inflamm (2010) 1.04
Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis (2004) 1.04
Dynamic states of the DNA repair enzyme AlkB regulate product release. EMBO Rep (2008) 1.03
Extended transsphenoidal approach for pituitary adenomas invading the anterior cranial base, cavernous sinus, and clivus: a single-center experience with 126 consecutive cases. J Neurosurg (2010) 1.03
Recombinant baculovirus containing the diphtheria toxin A gene for malignant glioma therapy. Cancer Res (2006) 1.03
Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation. J Biol Chem (2005) 1.03
TNF gene polymorphisms and Helicobacter Pylori infection in gastric carcinogenesis in Chinese population. Am J Gastroenterol (2005) 1.03
Role for nitric oxide in permeability of hippocampal neuronal hemichannels during oxygen glucose deprivation. J Neurosci Res (2008) 1.02
Characterization and source identification of polycyclic aromatic hydrocarbons (PAHs) in river bank soils. Chemosphere (2008) 1.02
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol Aging (2012) 1.02
The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.02
Serum macrophage migration-inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer. Cancer (2009) 1.01
Single-crystalline MFe(2)O(4) nanotubes/nanorings synthesized by thermal transformation process for biological applications. ACS Nano (2009) 1.01
Dose-risk and duration-risk relationships between aspirin and colorectal cancer: a meta-analysis of published cohort studies. PLoS One (2013) 1.01