Published in Cell on March 24, 2006
Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Molecular basis of metastasis. N Engl J Med (2008) 8.19
Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell (2008) 7.69
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature (2008) 5.59
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest (2011) 4.43
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell (2010) 4.25
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
Cancer micrometastases. Nat Rev Clin Oncol (2009) 3.69
Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res (2008) 3.67
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance. Cell Cycle (2009) 3.60
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev (2010) 3.24
Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res (2010) 3.19
Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer. Nat Rev Cancer (2009) 3.06
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol (2008) 2.85
MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83
Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev (2009) 2.76
Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation? Cell Cycle (2007) 2.55
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature (2008) 2.54
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res (2010) 2.54
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev (2009) 2.40
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res (2008) 2.29
Axillary dissection versus no axillary dissection in elderly patients with breast cancer and no palpable axillary nodes: results after 15 years of follow-up. Ann Surg Oncol (2010) 2.14
Telomere and telomerase in stem cells. Br J Cancer (2007) 2.09
Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc (2010) 1.96
A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res (2012) 1.92
Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome (2007) 1.88
Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ther (2008) 1.83
TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene (2010) 1.81
CD44v6 dependence of premetastatic niche preparation by exosomes. Neoplasia (2009) 1.80
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells (2015) 1.75
Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev Biol (2007) 1.74
MicroRNAs, cancer and cancer stem cells. Cancer Lett (2010) 1.65
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer. Theranostics (2015) 1.62
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev (2010) 1.57
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol Cancer Res (2012) 1.55
Epithelial to mesenchymal transition by TGFβ-1 induction increases stemness characteristics in primary non small cell lung cancer cell line. PLoS One (2011) 1.48
A stochastic model for cancer stem cell origin in metastatic colon cancer. Cancer Res (2008) 1.48
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev (2010) 1.46
DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer (2011) 1.45
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res (2008) 1.42
Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes. Mol Cancer (2013) 1.41
Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics. Cancer Res (2008) 1.40
Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med (2007) 1.38
Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proc Natl Acad Sci U S A (2008) 1.36
(A)symmetric stem cell replication and cancer. PLoS Comput Biol (2007) 1.36
Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage. Proc Natl Acad Sci U S A (2009) 1.31
APC and its modifiers in colon cancer. Adv Exp Med Biol (2009) 1.28
In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines. PLoS One (2008) 1.27
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Res (2008) 1.24
The role of microRNAs in breast cancer migration, invasion and metastasis. Int J Mol Sci (2012) 1.24
The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila. Cell Stem Cell (2010) 1.23
Mitochondria in stem cells. Mitochondrion (2007) 1.22
Which are the cells of origin in merkel cell carcinoma? J Skin Cancer (2012) 1.21
p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2015) 1.20
Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res (2010) 1.19
Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors. PLoS One (2010) 1.17
Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis (2014) 1.17
The expressions of stem cell markers: Oct4, Nanog, Sox2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines. Anat Cell Biol (2014) 1.15
Functional sphere profiling reveals the complexity of neuroblastoma tumor-initiating cell model. Neoplasia (2011) 1.15
Prevalence of epithelial ovarian cancer stem cells correlates with recurrence in early-stage ovarian cancer. J Oncol (2011) 1.15
Spheres derived from lung adenocarcinoma pleural effusions: molecular characterization and tumor engraftment. PLoS One (2011) 1.14
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther (2012) 1.13
Ionizing radiation induces stemness in cancer cells. PLoS One (2012) 1.12
Cancer genes hypermethylated in human embryonic stem cells. PLoS One (2008) 1.12
From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer. Cell Res (2011) 1.12
TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence. Cell Cycle (2013) 1.12
Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clin Cancer Res (2014) 1.11
Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays. PLoS One (2011) 1.11
Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer. J Biol Chem (2012) 1.10
Nanovehicular intracellular delivery systems. J Pharm Sci (2008) 1.10
Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance. Breast Cancer Res (2008) 1.09
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway. J Cell Biol (2008) 1.08
Impact of tiny miRNAs on cancers. World J Gastroenterol (2007) 1.08
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biol (2009) 1.08
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes Dev (2011) 1.08
Ovarian cancer stem cells and inflammation. Cancer Biol Ther (2011) 1.06
Smoothened as a new therapeutic target for human osteosarcoma. Mol Cancer (2010) 1.06
Pathways to tumorigenesis--modeling mutation acquisition in stem cells and their progeny. Neoplasia (2008) 1.04
Regulation of stem cell populations by microRNAs. Adv Exp Med Biol (2013) 1.04
A simple mathematical model based on the cancer stem cell hypothesis suggests kinetic commonalities in solid tumor growth. PLoS One (2012) 1.04
Evolving concepts in lung carcinogenesis. Semin Respir Crit Care Med (2011) 1.03
Synergistic combinations of multiple chemotherapeutic agents in high capacity poly(2-oxazoline) micelles. Mol Pharm (2012) 1.03
A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. Cell Stem Cell (2012) 1.02
Somatic cell lineage is required for differentiation and not maintenance of germline stem cells in Drosophila testes. Proc Natl Acad Sci U S A (2012) 1.00
The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer. PLoS One (2009) 1.00
TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis. Oncotarget (2014) 0.99
Regulation of inflammation by the NF-κB pathway in ovarian cancer stem cells. Am J Reprod Immunol (2010) 0.99
Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A (2011) 0.99
Role of cancer stem cells in pancreatic ductal adenocarcinoma. Nat Rev Clin Oncol (2009) 0.99
Cancer stem cells: a novel paradigm for cancer prevention and treatment. Mini Rev Med Chem (2010) 0.99
Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros. Stem Cells (2009) 0.98
Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells. Br J Cancer (2009) 0.98
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest (2014) 0.97
Aging and inflammation: etiological culprits of cancer. Curr Aging Sci (2009) 0.97
Cancer stem cells, a fuzzy evolving concept: a cell population or a cell property? Cell Cycle (2013) 0.97