Published in Proc Natl Acad Sci U S A on March 04, 2015
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment. Mol Cancer (2016) 1.51
ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion. Oncotarget (2016) 0.92
p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene (2015) 0.91
Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system. Cell Cycle (2015) 0.89
ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis. Oncotarget (2016) 0.87
Pathway Regulation of p63, a Director of Epithelial Cell Fate. Front Endocrinol (Lausanne) (2015) 0.85
Hedgehog Signaling in the Maintenance of Cancer Stem Cells. Cancers (Basel) (2015) 0.85
TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2(+) neutrophils. Oncogene (2016) 0.82
P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development. Cell Death Dis (2016) 0.82
The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer (2015) 0.81
Impact of Mediterranean diet on metabolic syndrome, cancer and longevity. Oncotarget (2016) 0.81
Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis. Cell Death Dis (2015) 0.79
Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer. Sci Rep (2017) 0.78
Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway. PLoS One (2016) 0.77
Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel) (2016) 0.77
Ultraconserved long non-coding RNA uc.63 in breast cancer. Oncotarget (2016) 0.76
Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis. Oncogene (2016) 0.76
Metabolic pathways regulated by TAp73 in response to oxidative stress. Oncotarget (2016) 0.76
Targeting the Hedgehog Pathway in Pediatric Medulloblastoma. Cancers (Basel) (2015) 0.76
Characterization of cervical cancer stem cell-like cells: phenotyping, stemness, and human papilloma virus co-receptor expression. Oncotarget (2016) 0.76
Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis. Oncotarget (2016) 0.75
Anti-Cancer Phytometabolites Targeting Cancer Stem Cells. Curr Genomics (2017) 0.75
Personalized Stem Cell Therapy to Correct Corneal Defects Due to a Unique Homozygous-Heterozygous Mosaicism of Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome. Stem Cells Transl Med (2016) 0.75
TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway. Oncogene (2016) 0.75
Oncogenic Intra-p53 Family Member Interactions in Human Cancers. Front Oncol (2016) 0.75
p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression. Oncotarget (2016) 0.75
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies. Mol Cancer (2017) 0.75
ΔNp63α modulates histone methyl transferase SETDB1 to transcriptionally repress target genes in cancers. Cell Death Discov (2016) 0.75
Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma. Stem Cells Int (2017) 0.75
p63 role in breast cancer. Aging (Albany NY) (2016) 0.75
Hedgehog signaling in the stomach. Curr Opin Pharmacol (2016) 0.75
Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma. Oncotarget (2017) 0.75
Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem (2016) 0.75
Cancer stem cells and early stage basal-like breast cancer. World J Obstet Gynecol (2016) 0.75
HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability. J Exp Clin Cancer Res (2016) 0.75
Thyrospheres from B-CPAP Cell Line with BRAF and TERT Promoter Mutations have Different Functional and Molecular Features than Parental Cells. J Cancer (2017) 0.75
New paradigms for the Hedgehog signaling network in mammary gland development and breast Cancer. Biochim Biophys Acta (2017) 0.75
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature (2012) 20.47
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell (2009) 6.64
p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell (2007) 6.50
Stem cells and cancer: two faces of eve. Cell (2006) 6.13
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell (2010) 5.57
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol (2006) 5.17
Subtypes of breast cancer show preferential site of relapse. Cancer Res (2008) 4.38
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell (2014) 4.17
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci (2009) 3.74
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell (2008) 3.01
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res (2004) 2.55
Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer (2007) 2.41
Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol (2010) 2.20
p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol (2001) 2.19
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet (2010) 2.14
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development (2012) 1.97
Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. Stem Cells (2012) 1.94
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A (2007) 1.70
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ (2010) 1.50
The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. J Biol Chem (2005) 1.49
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Res (2011) 1.25
Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proc Natl Acad Sci U S A (2008) 1.22
ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol (2014) 1.19
Frizzled7 as an emerging target for cancer therapy. Cell Signal (2011) 1.16
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15
The C-terminus of p63 contains multiple regulatory elements with different functions. Cell Death Dis (2010) 1.07
p63 overexpression induces the expression of Sonic Hedgehog. Mol Cancer Res (2006) 1.06
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress. Cell Death Differ (2013) 1.00
The relationship between p63 and p53 expression in normal and neoplastic breast tissue. Arch Pathol Lab Med (2003) 0.99
NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest (2014) 0.97
Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway. Cancer Sci (2010) 0.95
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation. PLoS One (2011) 0.94
Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53. Int J Oncol (2008) 0.89
Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci U S A (2013) 0.88
ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2. BMC Cancer (2014) 0.83
Angiomodulin is required for cardiogenesis of embryonic stem cells and is maintained by a feedback loop network of p63 and Activin-A. Stem Cell Res (2013) 0.79
Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma. Proc Natl Acad Sci U S A (2014) 0.92