Published in Endocrinology on March 30, 2006
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov (2009) 1.92
Thyroid hormones and cardiovascular disease. Nat Rev Cardiol (2016) 0.93
The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology (2011) 0.91
Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev (2008) 0.90
The role of thyroid hormone signaling in the prevention of digestive system cancers. Int J Mol Sci (2013) 0.83
Thyroid hormone analogues and derivatives: Actions in fatty liver. World J Hepatol (2014) 0.83
Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. Int J Endocrinol (2015) 0.75
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med (2004) 2.96
Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci (2003) 2.73
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Progenitor-derived hepatocellular carcinoma model in the rat. Hepatology (2010) 2.03
Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol (2007) 1.91
Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology (2005) 1.82
Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A (2006) 1.79
Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect (2010) 1.75
Riskard 2005. New tools for prediction of cardiovascular disease risk derived from Italian population studies. Nutr Metab Cardiovasc Dis (2005) 1.65
Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice. Hepatology (2011) 1.61
Tri-iodothyronine induces hepatocyte proliferation by protein kinase A-dependent β-catenin activation in rodents. Hepatology (2014) 1.59
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A (2005) 1.52
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem (2006) 1.52
Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol (2008) 1.51
In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain. Endocrinology (2011) 1.50
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology (2003) 1.42
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res (2009) 1.39
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev (2006) 1.34
Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. FASEB J (2007) 1.34
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem (2002) 1.28
Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke (2007) 1.23
Tissue distribution and cardiac metabolism of 3-iodothyronamine. Endocrinology (2010) 1.22
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A (2003) 1.17
Toward deciphering the code to aminergic G protein-coupled receptor drug design. Chem Biol (2008) 1.16
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. FASEB J (2008) 1.12
Prevalence of cholesteryl ester storage disease. Arterioscler Thromb Vasc Biol (2007) 1.11
A common set of immediate-early response genes in liver regeneration and hyperplasia. Hepatology (2003) 1.08
Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol (2007) 1.08
Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. J Biol Chem (2004) 1.06
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Dev Biol (2008) 1.05
A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem (2002) 1.05
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. Rapid Commun Mass Spectrom (2008) 1.05
Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors. Eur J Pharmacol (2008) 1.04
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology (2006) 1.04
Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli. Hepatology (2002) 1.04
Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis. Endocrinology (2010) 1.04
Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology (2003) 1.04
Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect (2005) 1.04
Synthesis and biological evaluation of SERMs with potent nongenomic estrogenic activity. ChemMedChem (2006) 1.03
Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem (2007) 1.03
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res (2010) 1.03
Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist. ACS Chem Biol (2006) 1.01
Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype. Hepatology (2009) 0.99
Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor. Biochemistry (2008) 0.98
Detection of 3-iodothyronamine in human patients: a preliminary study. J Clin Endocrinol Metab (2011) 0.95
The proangiogenic action of thyroid hormone analogue GC-1 is initiated at an integrin. J Cardiovasc Pharmacol (2005) 0.94
Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum. J Chromatogr A (2008) 0.94
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology (2002) 0.93
Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology (2008) 0.93
The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology (2010) 0.92
Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. EMBO J (2006) 0.92
Thyroid hormone receptor-beta-selective agonist GC-24 spares skeletal muscle type I to II fiber shift. Cell Tissue Res (2005) 0.92
Central effects of thyronamines on glucose metabolism in rats. J Endocrinol (2009) 0.92
Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology (2012) 0.92
Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo. Chembiochem (2009) 0.92
The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. J Bone Miner Res (2004) 0.92
Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab (2003) 0.92
Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP. Hepatology (2004) 0.91
Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. Bioorg Med Chem Lett (2008) 0.90
Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP. Carcinogenesis (2003) 0.90
Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion. Cardiovasc Drugs Ther (2011) 0.90
Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry. J Chromatogr A (2012) 0.89
Incidence of diabetes mellitus among children of Italian migrants substantiates the role of genetic factors in the pathogenesis of type 1 diabetes. Eur J Pediatr (2008) 0.88
TRbeta is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells. J Hepatol (2010) 0.88
Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology (2004) 0.88
Structural determinants of selective thyromimetics. J Med Chem (2003) 0.88
Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines. Mol Cell Endocrinol (2008) 0.87
Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. J Pharmacol Exp Ther (2010) 0.87
Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. J Biol Chem (2004) 0.87
Effects of chronic hyperinsulinemia in insulin-resistant patients. Curr Diab Rep (2008) 0.87
Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression. Endocrinology (2005) 0.86
Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol (2002) 0.86
The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). ACS Chem Biol (2009) 0.86
Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration. Hepatology (2014) 0.85
3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice. Br J Pharmacol (2012) 0.85
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands. Bioorg Med Chem Lett (2004) 0.85
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents. Bioorg Med Chem (2007) 0.85
Uptake and metabolic effects of 3-iodothyronamine in hepatocytes. J Endocrinol (2014) 0.85
Endogenous 3-iodothyronamine (T1AM): more than we bargained for. J Clin Endocrinol Metab (2011) 0.84
Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice. J Clin Invest (2011) 0.84
Thyroid hormone induces cyclin D1 nuclear translocation and DNA synthesis in adult rat cardiomyocytes. FASEB J (2006) 0.84