Published in J Biol Chem on March 30, 2004
Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes. Thyroid (2009) 1.71
Amphibian metamorphosis. Dev Biol (2007) 1.43
Unliganded thyroid hormone receptor α regulates developmental timing via gene repression in Xenopus tropicalis. Endocrinology (2014) 1.24
Apoptosis in amphibian organs during metamorphosis. Apoptosis (2010) 0.93
Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev (2008) 0.90
Thyroid hormone and tissue repair: new tricks for an old hormone? J Thyroid Res (2013) 0.85
New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider? Heart Fail Rev (2011) 0.84
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. BMC Struct Biol (2008) 0.81
Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Curr Chem Genom Transl Med (2014) 0.80
Cross-talk between the thyroid and liver: a new target for nonalcoholic fatty liver disease treatment. World J Gastroenterol (2013) 0.79
Thyroid Hormone-disrupting Effects and the Amphibian Metamorphosis Assay. J Toxicol Pathol (2012) 0.78
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat Med (2004) 2.96
Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci (2003) 2.73
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol (2007) 1.91
Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A (2006) 1.79
Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect (2010) 1.75
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem (2006) 1.52
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A (2005) 1.52
Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol (2008) 1.51
In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain. Endocrinology (2011) 1.50
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology (2003) 1.42
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res (2009) 1.39
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev (2006) 1.34
Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. FASEB J (2007) 1.34
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem (2002) 1.28
Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke (2007) 1.23
Tissue distribution and cardiac metabolism of 3-iodothyronamine. Endocrinology (2010) 1.22
Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation. Blood (2007) 1.17
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A (2003) 1.17
Toward deciphering the code to aminergic G protein-coupled receptor drug design. Chem Biol (2008) 1.16
Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol (2007) 1.08
Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. J Biol Chem (2004) 1.06
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Dev Biol (2008) 1.05
A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem (2002) 1.05
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. Rapid Commun Mass Spectrom (2008) 1.05
Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors. Eur J Pharmacol (2008) 1.04
Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology (2003) 1.04
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology (2006) 1.04
Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis. Endocrinology (2010) 1.04
Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect (2005) 1.04
Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem (2007) 1.03
Synthesis and biological evaluation of SERMs with potent nongenomic estrogenic activity. ChemMedChem (2006) 1.03
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res (2010) 1.03
Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist. ACS Chem Biol (2006) 1.01
The transcription factor basic transcription element-binding protein 1 is a direct thyroid hormone response gene in the frog Xenopus laevis. Endocrinology (2002) 1.01
Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor. Biochemistry (2008) 0.98
Detection of 3-iodothyronamine in human patients: a preliminary study. J Clin Endocrinol Metab (2011) 0.95
The proangiogenic action of thyroid hormone analogue GC-1 is initiated at an integrin. J Cardiovasc Pharmacol (2005) 0.94
Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum. J Chromatogr A (2008) 0.94
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology (2002) 0.93
Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology (2008) 0.93
The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology (2010) 0.92
Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab (2003) 0.92
Thyroid hormone receptor-beta-selective agonist GC-24 spares skeletal muscle type I to II fiber shift. Cell Tissue Res (2005) 0.92
Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. EMBO J (2006) 0.92
The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. J Bone Miner Res (2004) 0.92
Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo. Chembiochem (2009) 0.92
Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology (2012) 0.92
Central effects of thyronamines on glucose metabolism in rats. J Endocrinol (2009) 0.92
Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion. Cardiovasc Drugs Ther (2011) 0.90
Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. Bioorg Med Chem Lett (2008) 0.90
Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry. J Chromatogr A (2012) 0.89
Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology (2004) 0.88
Structural determinants of selective thyromimetics. J Med Chem (2003) 0.88
Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines. Mol Cell Endocrinol (2008) 0.87
Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. J Pharmacol Exp Ther (2010) 0.87
The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). ACS Chem Biol (2009) 0.86
Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol (2002) 0.86
Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression. Endocrinology (2005) 0.86
3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice. Br J Pharmacol (2012) 0.85
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands. Bioorg Med Chem Lett (2004) 0.85
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents. Bioorg Med Chem (2007) 0.85
Uptake and metabolic effects of 3-iodothyronamine in hepatocytes. J Endocrinol (2014) 0.85
Endogenous 3-iodothyronamine (T1AM): more than we bargained for. J Clin Endocrinol Metab (2011) 0.84
Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D₃ markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription. J Med Chem (2010) 0.83
Modulation of cardiac ionic homeostasis by 3-iodothyronamine. J Cell Mol Med (2009) 0.83
Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus. Exp Hematol (2009) 0.83
3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells. J Mol Endocrinol (2011) 0.82
Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms. Endocrinology (2003) 0.82
Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem (2005) 0.82
Analysis of thyroid hormone receptor betaA mRNA expression in Xenopus laevis tadpoles as a means to detect agonism and antagonism of thyroid hormone action. Toxicol Appl Pharmacol (2005) 0.82
Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis? Mol Cell Endocrinol (2011) 0.82
3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology? Mol Biosyst (2010) 0.81
The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology (2006) 0.81
Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists. J Am Chem Soc (2005) 0.81
Few things in life are "free": cellular uptake of steroid hormones by an active transport mechanism. Mol Interv (2005) 0.81
Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. Mol Biosyst (2010) 0.81
Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4. Endocrinology (2012) 0.80
A-ring analogs of 1,25-dihydroxyvitamin D(3). Arch Biochem Biophys (2011) 0.80
Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem (2002) 0.80
Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther (2007) 0.80
ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation. J Biol Chem (2011) 0.80
Selective thyroid hormone receptor modulators. Curr Top Med Chem (2003) 0.79
Cardiac effects of thyronamines. Heart Fail Rev (2008) 0.79
Screening of selective inhibitors of 1α,25-dihydroxyvitamin D3 24-hydroxylase using recombinant human enzyme expressed in Escherichia coli. Biochemistry (2010) 0.79
The thyroid hormone receptor (TR) beta-selective agonist GC-1 inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Calcif Tissue Int (2009) 0.78
Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells. ACS Chem Neurosci (2016) 0.77
Binding and catalysis: a thermodynamic study on a catalytic antibody system. Chembiochem (2003) 0.77
The diagnostic accuracy of 64-detector cardiac computed tomography compared with stress nuclear imaging in patients undergoing invasive cardiac catheterization. J Comput Assist Tomogr (2010) 0.77