Published in J Clin Endocrinol Metab on June 01, 2011
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In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain. Endocrinology (2011) 1.50
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology (2003) 1.42
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res (2009) 1.39
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev (2006) 1.34
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Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol (2007) 1.08
Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. J Biol Chem (2004) 1.06
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Dev Biol (2008) 1.05
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Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. Rapid Commun Mass Spectrom (2008) 1.05
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Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology (2003) 1.04
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology (2006) 1.04
Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis. Endocrinology (2010) 1.04
Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect (2005) 1.04
Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem (2007) 1.03
Synthesis and biological evaluation of SERMs with potent nongenomic estrogenic activity. ChemMedChem (2006) 1.03
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res (2010) 1.03
Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist. ACS Chem Biol (2006) 1.01
Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor. Biochemistry (2008) 0.98
Detection of 3-iodothyronamine in human patients: a preliminary study. J Clin Endocrinol Metab (2011) 0.95
The proangiogenic action of thyroid hormone analogue GC-1 is initiated at an integrin. J Cardiovasc Pharmacol (2005) 0.94
Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum. J Chromatogr A (2008) 0.94
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology (2002) 0.93
Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology (2008) 0.93
The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology (2010) 0.92
Central effects of thyronamines on glucose metabolism in rats. J Endocrinol (2009) 0.92
Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology (2012) 0.92
The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. J Bone Miner Res (2004) 0.92
Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo. Chembiochem (2009) 0.92
Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. EMBO J (2006) 0.92
Thyroid hormone receptor-beta-selective agonist GC-24 spares skeletal muscle type I to II fiber shift. Cell Tissue Res (2005) 0.92
Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab (2003) 0.92
Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion. Cardiovasc Drugs Ther (2011) 0.90
Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. Bioorg Med Chem Lett (2008) 0.90
Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry. J Chromatogr A (2012) 0.89
Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology (2004) 0.88
Structural determinants of selective thyromimetics. J Med Chem (2003) 0.88
Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines. Mol Cell Endocrinol (2008) 0.87
Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. J Biol Chem (2004) 0.87
Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. J Pharmacol Exp Ther (2010) 0.87
The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). ACS Chem Biol (2009) 0.86
Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol (2002) 0.86
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands. Bioorg Med Chem Lett (2004) 0.85
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents. Bioorg Med Chem (2007) 0.85
Modulation of cardiac ionic homeostasis by 3-iodothyronamine. J Cell Mol Med (2009) 0.83
Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms. Endocrinology (2003) 0.82
Analysis of thyroid hormone receptor betaA mRNA expression in Xenopus laevis tadpoles as a means to detect agonism and antagonism of thyroid hormone action. Toxicol Appl Pharmacol (2005) 0.82
Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem (2005) 0.82
Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis? Mol Cell Endocrinol (2011) 0.82
3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells. J Mol Endocrinol (2011) 0.82
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Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists. J Am Chem Soc (2005) 0.81
Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. Mol Biosyst (2010) 0.81
The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology (2006) 0.81
Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem (2002) 0.80
ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation. J Biol Chem (2011) 0.80
Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4. Endocrinology (2012) 0.80
Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther (2007) 0.80
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The thyroid hormone receptor (TR) beta-selective agonist GC-1 inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Calcif Tissue Int (2009) 0.78
Binding and catalysis: a thermodynamic study on a catalytic antibody system. Chembiochem (2003) 0.77
Effects of acute microinjections of the thyroid hormone derivative 3-iodothyronamine to the preoptic region of adult male rats on sleep, thermoregulation and motor activity. Horm Behav (2013) 0.76
Direct hydroxide attack is a plausible mechanism for amidase antibody 43C9. J Comput Chem (2003) 0.76
Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology (2014) 0.76
Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways. J Steroid Biochem Mol Biol (2009) 0.75
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Design and synthesis of receptor ligands. Methods Enzymol (2003) 0.75