Published in EMBO J on April 06, 2006
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell (2006) 3.00
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev (2010) 2.88
Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell (2011) 2.40
Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature (2010) 2.03
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proc Natl Acad Sci U S A (2009) 1.88
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev (2010) 1.86
Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev (2009) 1.76
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly. Genes Dev (2010) 1.71
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication. Science (2014) 1.69
Reduced expression of GINS complex members induces hallmarks of pre-malignancy in primary untransformed human cells. Cell Cycle (2009) 1.49
GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome. Mol Syst Biol (2010) 1.45
Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis. Proc Natl Acad Sci U S A (2012) 1.44
Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins. EMBO J (2006) 1.44
DNA polymerase epsilon: a polymerase of unusual size (and complexity). Prog Nucleic Acid Res Mol Biol (2008) 1.44
Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J (2012) 1.37
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication. Nucleic Acids Res (2009) 1.35
Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.32
Mechanisms for initiating cellular DNA replication. Annu Rev Biochem (2013) 1.28
Helicase loading at chromosomal origins of replication. Cold Spring Harb Perspect Biol (2013) 1.26
Crystal structure of the human GINS complex. Genes Dev (2007) 1.25
Regulation of the initiation step of DNA replication by cyclin-dependent kinases. Chromosoma (2010) 1.24
Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. J Biol Chem (2011) 1.21
The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. EMBO J (2008) 1.15
Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J (2012) 1.15
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J (2014) 1.14
A role for H2B ubiquitylation in DNA replication. Mol Cell (2012) 1.11
Chromosome Duplication in Saccharomyces cerevisiae. Genetics (2016) 1.11
Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain. Mol Biol Cell (2008) 1.11
Origin plasticity during budding yeast DNA replication in vitro. EMBO J (2014) 1.08
The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol (2010) 1.07
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated. Chromosoma (2014) 1.03
GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding. J Biol Chem (2011) 1.00
CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol Biol Cell (2011) 1.00
Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J (2011) 1.00
The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem (2013) 0.99
Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. EMBO J (2016) 0.97
Structure and evolutionary origins of the CMG complex. Chromosoma (2013) 0.96
Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress. J Biol Chem (2013) 0.96
Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. J Biol Chem (2011) 0.95
Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem (2011) 0.95
How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. Mol Cell (2016) 0.92
H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing. Nucleic Acids Res (2015) 0.92
DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Mol Biol Cell (2012) 0.92
Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. Proc Natl Acad Sci U S A (2015) 0.91
Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res (2015) 0.88
Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae. PLoS Genet (2012) 0.88
Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation. Mol Biol Cell (2008) 0.87
Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase. J Biol Chem (2015) 0.86
ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes. J Mol Biol (2009) 0.85
GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast. Mol Biol Cell (2008) 0.84
DNA replication and the GINS complex: localization on extended chromatin fibers. Epigenetics Chromatin (2009) 0.84
Mathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplication. PLoS Comput Biol (2010) 0.84
A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS. Genomics Proteomics Bioinformatics (2006) 0.83
Retracted The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase. J Biol Chem (2015) 0.82
A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase. Nucleic Acids Res (2015) 0.81
Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression. Genome Res (2016) 0.79
Sld3-MCM Interaction Facilitated by Dbf4-Dependent Kinase Defines an Essential Step in Eukaryotic DNA Replication Initiation. Front Microbiol (2016) 0.76
The Intra-S Checkpoint Responses to DNA Damage. Genes (Basel) (2017) 0.76
A Positive-amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase. J Biol Chem (2017) 0.75
Insights into the Initiation of Eukaryotic DNA Replication. Nucleus (2015) 0.75
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. BMC Syst Biol (2012) 0.75
From structure to mechanism-understanding initiation of DNA replication. Genes Dev (2017) 0.75
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell (1997) 8.23
A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature (1998) 6.47
Two steps in the assembly of complexes at yeast replication origins in vivo. Cell (1994) 6.42
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Uninterrupted MCM2-7 function required for DNA replication fork progression. Science (2000) 6.27
Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol (2005) 5.82
Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell (1997) 5.15
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J Biol Chem (1997) 4.97
Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science (1994) 4.42
Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol Cell (2000) 4.22
Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev (2004) 4.19
Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature (1995) 4.00
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev (2003) 3.53
Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol (2000) 3.52
Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell (1995) 3.47
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A (2000) 3.35
The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J (1997) 3.35
The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev (1998) 3.15
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15
Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature (2003) 3.08
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev (2005) 3.07
Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism. Nat Struct Mol Biol (2005) 3.04
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication. EMBO J (2004) 3.02
Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc Natl Acad Sci U S A (1999) 2.96
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity. Proc Natl Acad Sci U S A (1999) 2.93
Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev (1998) 2.75
The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol (1994) 2.75
A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes Dev (2003) 2.75
Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J (2001) 2.70
Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. EMBO J (1998) 2.66
Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell (2005) 2.54
DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p. EMBO J (2000) 2.51
Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins. Bioessays (2003) 2.50
Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol Cell (1998) 2.49
The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein. J Biol Chem (2000) 2.29
Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. J Biol Chem (2003) 2.15
Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. Proc Natl Acad Sci U S A (2001) 2.14
Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells (2000) 2.12
Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading. Genes Dev (2000) 2.10
Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts. J Biol Chem (2000) 2.04
The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J Cell Biol (2002) 2.00
Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc Natl Acad Sci U S A (1996) 1.94
Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication. EMBO J (2003) 1.86
Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J Mol Biol (2005) 1.74
CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol Cell (2000) 1.69
A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. Eur J Biochem (1997) 1.65
Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding. Mol Biol Cell (2003) 1.59
MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell (2001) 1.58
CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45. Genes Cells (2003) 1.57
CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc Natl Acad Sci U S A (1997) 1.56
Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. EMBO J (1998) 1.45
SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast. Mol Biol Cell (2002) 1.40
DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process. J Biol Chem (2004) 1.34
A novel intermediate in initiation complex assembly for fission yeast DNA replication. Mol Biol Cell (2004) 1.19
Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe. Genes Cells (1998) 1.09
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36
Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature (2003) 3.08
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev (2005) 3.07
A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. EMBO J (2009) 2.17
Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. Curr Biol (2013) 1.93
Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase. Mol Biol Cell (2007) 1.70
The chromosome replication cycle. J Cell Sci (2002) 1.51
Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases. Mol Cell (2012) 1.49
Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J (2012) 1.37
The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex. Curr Biol (2009) 1.32
Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron. Sci STKE (2004) 1.29
Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nat Cell Biol (2008) 1.21
Eukaryotic replisome components cooperate to process histones during chromosome replication. Cell Rep (2013) 1.16
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome. J Biol Chem (2012) 0.98
Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. J Cell Sci (2012) 0.87
The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth. EMBO J (2012) 0.85
Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast. PLoS One (2013) 0.81
New insights into the chromosome cycle. Conference on the Replication & Segregation of Chromosomes. EMBO Rep (2008) 0.76