Published in Cell on July 08, 2011
Regulated eukaryotic DNA replication origin firing with purified proteins. Nature (2015) 2.07
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast. EMBO J (2011) 1.94
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66
Rif1 is a global regulator of timing of replication origin firing in fission yeast. Genes Dev (2012) 1.57
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Quality control in the initiation of eukaryotic DNA replication. Philos Trans R Soc Lond B Biol Sci (2011) 1.40
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The replication initiation protein Sld2 regulates helicase assembly. J Biol Chem (2013) 0.99
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Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem (2011) 0.95
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Xenopus Mcm10 is a CDK-substrate required for replication fork stability. Cell Cycle (2016) 0.92
DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast. Mol Biol Cell (2012) 0.92
Crystal structure of human CDC7 kinase in complex with its activator DBF4. Nat Struct Mol Biol (2012) 0.91
Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase. Proc Natl Acad Sci U S A (2015) 0.91
Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc Natl Acad Sci U S A (2017) 0.90
Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits. J Biol Chem (2013) 0.89
Structure of human Cdc45 and implications for CMG helicase function. Nat Commun (2016) 0.89
RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells. Cell Cycle (2015) 0.89
Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly. Genes Dev (2015) 0.89
Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Res (2015) 0.88
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Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase. J Biol Chem (2015) 0.86
Cdc45 is limiting for replication initiation in humans. Cell Cycle (2016) 0.86
Cdc7-Dbf4 is a gene-specific regulator of meiotic transcription in yeast. Mol Cell Biol (2011) 0.86
Chromatin Constrains the Initiation and Elongation of DNA Replication. Mol Cell (2016) 0.85
Mcm10 self-association is mediated by an N-terminal coiled-coil domain. PLoS One (2013) 0.85
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts. Cell Cycle (2015) 0.85
Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA. Cell Cycle (2016) 0.85
Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase. Genes Dev (2017) 0.84
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Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma (2016) 0.81
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Differential chromatin structure encompassing replication origins in transformed and normal cells. Genes Cancer (2012) 0.79
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Drosophila Mcm10 is required for DNA replication and differentiation in the compound eye. PLoS One (2014) 0.78
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An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation. J Mol Biol (2016) 0.78
Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation. Chromosoma (2015) 0.78
Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget (2015) 0.78
Simultaneous measurement of passage through the restriction point and MCM loading in single cells. Nucleic Acids Res (2015) 0.78
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Building up the machinery for DNA replication. Cell Cycle (2015) 0.76
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Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast. FEMS Yeast Res (2012) 0.76
Nucleosome occupancy as a novel chromatin parameter for replication origin functions. Genome Res (2016) 0.75
Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation. J Biol Chem (2014) 0.75
TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin. J Biol Chem (2016) 0.75
New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress. Nucleic Acids Res (2016) 0.75
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. J Biol Chem (2016) 0.75
Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis. Biomolecules (2016) 0.75
Hpz1 modulates the G1-S transition in fission yeast. PLoS One (2012) 0.75
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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature (2006) 4.94
CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature (2006) 4.51
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Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol Cell (2002) 2.55
Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Mol Cell (2004) 2.52
The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature (2010) 2.50
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Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev (2000) 2.04
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CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev (2010) 1.86
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Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell (2010) 1.83
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Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev (2009) 1.76
Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C. Genes Dev (2005) 1.62
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Evidence of abundant stop codon readthrough in Drosophila and other metazoa. Genome Res (2011) 1.60
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Mariprofundus ferrooxydans PV-1 the first genome of a marine Fe(II) oxidizing Zetaproteobacterium. PLoS One (2011) 1.40
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Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases. EMBO J (2011) 1.25
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CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6. Genes Dev (2011) 1.16
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Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition. J Biol Chem (2007) 1.00
Knockdown of human MCM10 exhibits delayed and incomplete chromosome replication. Biochem Biophys Res Commun (2007) 0.95
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Mapping subunit location on the Saccharomyces cerevisiae origin recognition complex free and bound to DNA using a novel nanoscale biopointer. J Biol Chem (2004) 0.92
Sequential binding of SeqA to paired hemi-methylated GATC sequences mediates formation of higher order complexes. J Biol Chem (2003) 0.90
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Putting two heads together to unwind DNA. Cell (2009) 0.86
High-resolution 2D and 3D cryo-TEM reveals structural adaptations of two stalk-forming bacteria to an Fe-oxidizing lifestyle. Environ Microbiol (2011) 0.86
Human TopBP1 localization to the mitotic centrosome mediates mitotic progression. Exp Cell Res (2011) 0.85
BRE over-expression promotes growth of hepatocellular carcinoma. Biochem Biophys Res Commun (2009) 0.84
Structure and dynamics of hemimethylated GATC sites: implications for DNA-SeqA recognition. J Biol Chem (2003) 0.83
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Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy. J Mol Cell Cardiol (2013) 0.81
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Fungal endophyte increases the allelopathic effects of an invasive forb. Oecologia (2014) 0.80
Coronary venous capture of contrast during angiography. J Interv Cardiol (2006) 0.80
Using in situ voltammetry as a tool to identify and characterize habitats of iron-oxidizing bacteria: from fresh water wetlands to hydrothermal vent sites. Environ Sci Process Impacts (2014) 0.79
A DEAD-box RNA helicase produces two forms of transcript that differentially respond to cold stress in a cryophyte (Chorispora bungeana). Planta (2014) 0.78
Mesenchymal stem cells enhance the differentiation of c-kit+ cardiac stem cells. Front Biosci (Landmark Ed) (2012) 0.78
Conyza canadensis suppresses plant diversity in its nonnative ranges but not at home: a transcontinental comparison. New Phytol (2014) 0.77
High dose intracoronary N-acetylcysteine in a porcine model of ST-elevation myocardial infarction. J Thromb Thrombolysis (2013) 0.75
Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure. Am J Physiol Heart Circ Physiol (2003) 0.75