Mechanisms for initiating cellular DNA replication.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMID 23746253)

Published in Annu Rev Biochem on January 01, 2013

Authors

Alessandro Costa1, Iris V Hood, James M Berger

Author Affiliations

1: Clare Hall Laboratories, London Research Institute, Cancer Research UK, Hertfordshire, EN6 3LD United Kingdom. alessandro.costa@cancer.org.uk

Articles citing this

Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA. Mol Cell (2015) 1.50

Structure of the eukaryotic MCM complex at 3.8 Å. Nature (2015) 1.35

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase. Mol Cell (2014) 1.23

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver. Cell Metab (2016) 1.17

Crystal structure of the eukaryotic origin recognition complex. Nature (2015) 1.14

Multiple functions for Mcm2-7 ATPase motifs during replication initiation. Mol Cell (2014) 1.09

Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase. Cell Rep (2015) 1.03

Peaks cloaked in the mist: the landscape of mammalian replication origins. J Cell Biol (2015) 0.98

Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem (2015) 0.93

The cell cycle of archaea. Nat Rev Microbiol (2013) 0.92

Cell division in Corynebacterineae. Front Microbiol (2014) 0.91

Completion of DNA replication in Escherichia coli. Proc Natl Acad Sci U S A (2014) 0.88

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun (2015) 0.87

The fork and the kinase: a DNA replication tale from a CHK1 perspective. Mutat Res Rev Mutat Res (2014) 0.87

Timely binding of IHF and Fis to DARS2 regulates ATP-DnaA production and replication initiation. Nucleic Acids Res (2014) 0.86

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proc Natl Acad Sci U S A (2014) 0.86

RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts. Cell Cycle (2015) 0.85

Loading strategies of ring-shaped nucleic acid translocases and helicases. Curr Opin Struct Biol (2013) 0.84

MYC and the control of DNA replication. Cold Spring Harb Perspect Med (2014) 0.84

The Eukaryotic Replisome Goes Under the Microscope. Curr Biol (2016) 0.84

Structure and primase-mediated activation of a bacterial dodecameric replicative helicase. Nucleic Acids Res (2015) 0.83

Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins. Mol Cell (2015) 0.83

Nucleotide and partner-protein control of bacterial replicative helicase structure and function. Mol Cell (2013) 0.82

Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. Nat Commun (2015) 0.81

Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans. Front Physiol (2015) 0.81

Bacterial initiators form dynamic filaments on single-stranded DNA monomer by monomer. Nucleic Acids Res (2014) 0.80

Mechanisms and regulation of DNA replication initiation in eukaryotes. Crit Rev Biochem Mol Biol (2017) 0.79

Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe. Genome Biol (2015) 0.79

Plasmid replication initiator interactions with origin 13-mers and polymerase subunits contribute to strand-specific replisome assembly. Proc Natl Acad Sci U S A (2015) 0.79

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. Nucleic Acids Res (2016) 0.77

Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication. Elife (2016) 0.77

Frequent exchange of the DNA polymerase during bacterial chromosome replication. Elife (2017) 0.77

Characterization of the MCM homohexamer from the thermoacidophilic euryarchaeon Picrophilus torridus. Sci Rep (2015) 0.77

Replisome Assembly at Bacterial Chromosomes and Iteron Plasmids. Front Mol Biosci (2016) 0.76

Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation. Nucleic Acids Res (2016) 0.76

The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology. Int J Mol Sci (2016) 0.76

New insights into the GINS complex explain the controversy between existing structural models. Sci Rep (2017) 0.76

Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome. Proc Natl Acad Sci U S A (2016) 0.76

The Escherichia coli Cryptic Prophage Protein YfdR Binds to DnaA and Initiation of Chromosomal Replication Is Inhibited by Overexpression of the Gene Cluster yfdQ-yfdR-yfdS-yfdT. Front Microbiol (2016) 0.75

Cooperative DnaA binding to the negatively supercoiled datA locus stimulates DnaA-ATP hydrolysis. J Biol Chem (2016) 0.75

Cryo-EM of dynamic protein complexes in eukaryotic DNA replication. Protein Sci (2016) 0.75

Near-atomic structural model for bacterial DNA replication initiation complex and its functional insights. Proc Natl Acad Sci U S A (2016) 0.75

The Role of the N-Terminal Domains of Bacterial Initiator DnaA in the Assembly and Regulation of the Bacterial Replication Initiation Complex. Genes (Basel) (2017) 0.75

Mechanisms of DNA replication termination. Nat Rev Mol Cell Biol (2017) 0.75

From structure to mechanism-understanding initiation of DNA replication. Genes Dev (2017) 0.75

Articles cited by this

(truncated to the top 100)

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62

MCM proteins in DNA replication. Annu Rev Biochem (1999) 13.88

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res (1999) 11.30

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (1992) 11.06

Isolation and characterisation of a yeast chromosomal replicator. Nature (1979) 9.14

Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell (1997) 8.23

The dnaA protein complex with the E. coli chromosomal replication origin (oriC) and other DNA sites. Cell (1984) 7.27

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science (2000) 6.48

Two steps in the assembly of complexes at yeast replication origins in vivo. Cell (1994) 6.42

Duplex opening by dnaA protein at novel sequences in initiation of replication at the origin of the E. coli chromosome. Cell (1988) 6.42

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol (2006) 6.36

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Natl Acad Sci U S A (2006) 5.66

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A (1997) 5.51

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol (2001) 5.37

A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J Biol Chem (1997) 4.97

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature (2006) 4.94

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell (1996) 4.80

Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74

Evolutionary history and higher order classification of AAA+ ATPases. J Struct Biol (2004) 4.68

The Escherichia coli dnaB replication protein is a DNA helicase. J Biol Chem (1986) 4.56

CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature (2006) 4.51

The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (2000) 4.46

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J (1995) 4.40

The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat Struct Biol (2003) 4.27

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Mol Cell (2010) 4.24

Regulated replication of DNA microinjected into eggs of Xenopus laevis. Cell (1980) 4.24

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell (1995) 4.23

Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev (2007) 4.11

Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell (1997) 4.02

Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature (1995) 4.00

Regulation of early events in chromosome replication. Curr Biol (2004) 3.97

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature (1996) 3.89

Protein-DNA interactions at a yeast replication origin. Nature (1992) 3.87

Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication. Mol Cell (2006) 3.77

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Natl Acad Sci U S A (2009) 3.68

Identification of two origins of replication in the single chromosome of the archaeon Sulfolobus solfataricus. Cell (2004) 3.63

Deletion mutations affecting autonomously replicating sequence ARS1 of Saccharomyces cerevisiae. Mol Cell Biol (1984) 3.53

A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A (2000) 3.35

MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature (1995) 3.33

ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome. Cell (1987) 3.32

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature (1996) 3.26

XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature (2000) 3.25

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat Cell Biol (2005) 3.18

Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc Natl Acad Sci U S A (1988) 3.18

Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol (2002) 3.12

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell (2006) 3.08

The Mcm2-7 complex has in vitro helicase activity. Mol Cell (2008) 3.08

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature (2003) 3.08

Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism. Nat Struct Mol Biol (2005) 3.04

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc Natl Acad Sci U S A (1997) 3.01

MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts. J Biol Chem (2002) 3.00

The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity. Proc Natl Acad Sci U S A (1999) 2.93

The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev (2010) 2.88

Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Nucleic Acids Res (1998) 2.82

Conserved nucleosome positioning defines replication origins. Genes Dev (2010) 2.74

Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling. Nat Struct Mol Biol (2006) 2.73

Interaction of Escherichia coli dnaB and dnaC(D) gene products in vitro. Proc Natl Acad Sci U S A (1975) 2.68

Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell (1997) 2.67

Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. Genome Res (2009) 2.66

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. Mol Cell (2004) 2.66

Bacterial mode of replication with eukaryotic-like machinery in a hyperthermophilic archaeon. Science (2000) 2.64

Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. Nucleic Acids Res (2004) 2.62

The DNA unwinding element: a novel, cis-acting component that facilitates opening of the Escherichia coli replication origin. EMBO J (1989) 2.61

Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor. J Cell Biol (1997) 2.58

Eukaryotic DNA replication origins: many choices for appropriate answers. Nat Rev Mol Cell Biol (2010) 2.56

Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell (2011) 2.54

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell (2005) 2.54

Genome-wide characterization of fission yeast DNA replication origins. EMBO J (2006) 2.53

Evolution and classification of P-loop kinases and related proteins. J Mol Biol (2003) 2.52

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p. EMBO J (2000) 2.51

The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature (2010) 2.50

In vitro assembly of a prepriming complex at the origin of the Escherichia coli chromosome. J Biol Chem (1987) 2.47

Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) (2005) 2.46

Eukaryotic DNA replication control: lock and load, then fire. Curr Opin Cell Biol (2009) 2.45

Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor. J Cell Biol (1993) 2.44

Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III. Mol Cell Biol (1990) 2.44

Did DNA replication evolve twice independently? Nucleic Acids Res (1999) 2.44

ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J (1996) 2.42

The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. Proc Natl Acad Sci U S A (1999) 2.41

Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases. Cell (2011) 2.40

The bacterial replicative helicase DnaB evolved from a RecA duplication. Genome Res (2000) 2.39

G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat Cell Biol (1999) 2.39

The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37

Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev (2004) 2.36

Three replication origins in Sulfolobus species: synchronous initiation of chromosome replication and asynchronous termination. Proc Natl Acad Sci U S A (2004) 2.35

DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding. EMBO J (2004) 2.29

Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication. Mol Cell (2001) 2.28

Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC. Nat Rev Microbiol (2010) 2.27

Autoregulation of the dnaA gene of Escherichia coli K12. Mol Gen Genet (1985) 2.26

A Drosophila homolog of the yeast origin recognition complex. Science (1995) 2.20

DNA replication in the archaea. Microbiol Mol Biol Rev (2006) 2.17

Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science (2007) 2.10

Where does bacterial replication start? Rules for predicting the oriC region. Nucleic Acids Res (2004) 2.09

DnaA: controlling the initiation of bacterial DNA replication and more. Annu Rev Microbiol (2006) 2.07

Dynamic control of the DNA replication initiation protein DnaA by Soj/ParA. Cell (2008) 2.07

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control. Mol Cell (2000) 2.07

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature (2012) 2.07

The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation. FEBS Lett (1999) 2.04

Articles by these authors

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell (2005) 4.83

Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct (2006) 4.74

A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proc Natl Acad Sci U S A (2002) 4.16

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology. Q Rev Biophys (2008) 3.50

Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38

Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu Rev Biophys Biomol Struct (2004) 3.37

Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell (2003) 3.00

DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol (2007) 2.96

The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93

Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79

Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling. Nat Struct Mol Biol (2006) 2.73

The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69

All tangled up: how cells direct, manage and exploit topoisomerase function. Nat Rev Mol Cell Biol (2011) 2.66

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat Cell Biol (2006) 2.58

Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol (2004) 2.25

Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science (2007) 2.10

The structural basis for substrate specificity in DNA topoisomerase IV. J Mol Biol (2005) 2.08

Structure and function of the conserved core of histone deposition protein Asf1. Curr Biol (2003) 2.02

The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation. EMBO J (2002) 1.98

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep (2013) 1.96

The C-terminal domain of DNA gyrase A adopts a DNA-bending beta-pinwheel fold. Proc Natl Acad Sci U S A (2004) 1.93

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90

The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80

Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol (2002) 1.77

Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. J Synchrotron Radiat (2004) 1.70

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export. Nature (2011) 1.70

A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination. J Am Chem Soc (2006) 1.65

Binding mechanism of metal⋅NTP substrates and stringent-response alarmones to bacterial DnaG-type primases. Structure (2012) 1.64

The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore. Mol Cell (2004) 1.59

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59

Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell (2006) 1.58

Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol Cell (2005) 1.57

DNA stretching by bacterial initiators promotes replication origin opening. Nature (2011) 1.55

Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators. Cell (2008) 1.51

Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A (2003) 1.44

The nuts and bolts of ring-translocase structure and mechanism. Curr Opin Struct Biol (2011) 1.44

Identification of a DNA primase template tracking site redefines the geometry of primer synthesis. Nat Struct Mol Biol (2008) 1.42

Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proc Natl Acad Sci U S A (2010) 1.41

Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem (2008) 1.35

Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct Biol (2006) 1.34

Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. J Biol Chem (2006) 1.31

AAA+ ATPases in the initiation of DNA replication. Crit Rev Biochem Mol Biol (2008) 1.29

THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. Nat Struct Mol Biol (2009) 1.27

The MukF subunit of Escherichia coli condensin: architecture and functional relationship to kleisins. EMBO J (2005) 1.24

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Natl Acad Sci U S A (2012) 1.21

Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution. EMBO J (2003) 1.18

Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem (2006) 1.16

The bacterial DnaC helicase loader is a DnaB ring breaker. Cell (2013) 1.14

Regulation of bacterial priming and daughter strand synthesis through helicase-primase interactions. Nucleic Acids Res (2006) 1.13

Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci (2007) 1.11

Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator. J Biol Chem (2010) 1.10

A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function. Nucleic Acids Res (2010) 1.09

Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol (2012) 1.09

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding. J Biol Chem (2014) 1.08

Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus. Nucleic Acids Res (2004) 1.08

Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol Cell (2006) 1.07

Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases. Mol Microbiol (2008) 1.07

The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks. Nucleic Acids Res (2011) 1.07

Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI. Structure (2005) 1.06

A structural framework for replication origin opening by AAA+ initiation factors. Curr Opin Struct Biol (2012) 1.06

Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proc Natl Acad Sci U S A (2009) 1.05

Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J Mol Biol (2008) 1.03

Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis. Proteins (2010) 1.03

Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI. Nat Struct Mol Biol (2007) 1.02

Mechanisms for defining supercoiling set point of DNA gyrase orthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency. J Biol Chem (2012) 1.01

Contributions of folding cores to the thermostabilities of two ribonucleases H. Protein Sci (2002) 0.99

The role of DNA bending in type IIA topoisomerase function. Nucleic Acids Res (2013) 0.98

How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol (2008) 0.98

Molecular determinants of origin discrimination by Orc1 initiators in archaea. Nucleic Acids Res (2011) 0.98

ATP binding controls distinct structural transitions of Escherichia coli DNA gyrase in complex with DNA. Nat Struct Mol Biol (2012) 0.97

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (2005) 0.97

Mechanisms for defining supercoiling set point of DNA gyrase orthologs: I. A nonconserved acidic C-terminal tail modulates Escherichia coli gyrase activity. J Biol Chem (2012) 0.97

A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs. Proc Natl Acad Sci U S A (2010) 0.97

The crystal structure of the hinge domain of the Escherichia coli structural maintenance of chromosomes protein MukB. J Mol Biol (2009) 0.97

Macro-to-micro structural proteomics: native source proteins for high-throughput crystallization. PLoS One (2012) 0.96

Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein. Biochemistry (2009) 0.96

SnapShot: nucleic acid helicases and translocases. Cell (2008) 0.92

Two surfaces on the histone chaperone Rtt106 mediate histone binding, replication, and silencing. Proc Natl Acad Sci U S A (2011) 0.92

Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Proc Natl Acad Sci U S A (2009) 0.92

Narrowing substrate specificity in a directly evolved enzyme: the A293D mutant of aspartate aminotransferase. Biochemistry (2004) 0.91

Nanoscale protein assemblies from a circular permutant of the tobacco mosaic virus. Nano Lett (2010) 0.89

Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A. Protein Sci (2005) 0.89

Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol. Nucleic Acids Res (2006) 0.88

Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo. EMBO J (2013) 0.87

FASTDXL: a generalized screen to trap disulfide-stabilized complexes for use in structural studies. Structure (2007) 0.87

Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. Proteins (2010) 0.87

Emerging roles for plant topoisomerase VI. Chem Biol (2003) 0.86

Allosteric control of regulated scaffolding in membrane-associated guanylate kinases. Biochemistry (2009) 0.84

Distinct regions of the Escherichia coli ParC C-terminal domain are required for substrate discrimination by topoisomerase IV. J Mol Biol (2013) 0.83

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. Elife (2013) 0.83

Unraveling the early steps of prokaryotic replication. Curr Opin Struct Biol (2005) 0.83

Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design. ACS Chem Biol (2014) 0.83

Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines. Nucleic Acids Res (2008) 0.83

Real-time detection of DNA topological changes with a fluorescently labeled cruciform. Nucleic Acids Res (2013) 0.81

Crystallization and X-ray structure determination of an RNA-dependent hexameric helicase. Methods Enzymol (2012) 0.79

False memory syndrome and therapist liability to third parties for emotional distress injuries arising from recovered memory therapy: a general prohibition on liability and a limited liability exception. Spec Law Dig Health Care Law (2002) 0.76