Posttranscriptional control of T cell effector function by aerobic glycolysis.

PubWeight™: 6.30‹?› | Rank: Top 1%

🔗 View Article (PMC 3804311)

Published in Cell on June 06, 2013

Authors

Chih-Hao Chang1, Jonathan D Curtis, Leonard B Maggi, Brandon Faubert, Alejandro V Villarino, David O'Sullivan, Stanley Ching-Cheng Huang, Gerritje J W van der Windt, Julianna Blagih, Jing Qiu, Jason D Weber, Edward J Pearce, Russell G Jones, Erika L Pearce

Author Affiliations

1: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Articles citing this

(truncated to the top 100)

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells. Nat Biotechnol (2015) 4.09

Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol (2013) 3.74

Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 3.62

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nat Immunol (2014) 3.31

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell (2015) 3.03

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science (2014) 2.78

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity (2014) 2.63

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell (2015) 2.60

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest (2013) 2.50

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol (2013) 2.48

Bcl-6 directly represses the gene program of the glycolysis pathway. Nat Immunol (2014) 2.47

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell (2016) 2.39

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat Immunol (2013) 2.30

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell (2016) 2.28

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science (2016) 2.20

Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity (2014) 2.14

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab (2014) 2.06

T cell metabolism drives immunity. J Exp Med (2015) 2.06

Cell biology. Metabolic control of cell death. Science (2014) 1.98

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol (2014) 1.96

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc Natl Acad Sci U S A (2013) 1.90

Identification of transcriptional and metabolic programs related to mammalian cell size. Curr Biol (2014) 1.71

Molecular regulation of effector and memory T cell differentiation. Nat Immunol (2014) 1.70

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses. Immunity (2015) 1.60

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest (2014) 1.58

c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells. Nat Immunol (2014) 1.57

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol (2016) 1.55

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol (2014) 1.51

Metabolism of stromal and immune cells in health and disease. Nature (2014) 1.49

A guide to immunometabolism for immunologists. Nat Rev Immunol (2016) 1.41

Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function. Immunity (2016) 1.40

The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity (2014) 1.40

Mitochondria in the regulation of innate and adaptive immunity. Immunity (2015) 1.40

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest (2017) 1.40

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun (2015) 1.36

The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci (2016) 1.36

Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol (2014) 1.35

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Nat Med (2015) 1.35

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest (2015) 1.30

Lineage relationship of effector and memory T cells. Curr Opin Immunol (2013) 1.30

Targeting T cell metabolism for therapy. Trends Immunol (2015) 1.27

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity (2016) 1.27

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol (2014) 1.23

How metabolism generates signals during innate immunity and inflammation. J Biol Chem (2013) 1.22

Noncoding RNA and its associated proteins as regulatory elements of the immune system. Nat Immunol (2014) 1.15

Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol (2016) 1.15

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol (2015) 1.14

T cell metabolic fitness in antitumor immunity. Trends Immunol (2015) 1.12

Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J (2015) 1.11

S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate. Nature (2016) 1.11

Emerging concepts of T cell metabolism as a target of immunotherapy. Nat Immunol (2016) 1.08

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat Immunol (2016) 1.08

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs. Nat Commun (2015) 1.08

Glucose metabolism regulates T cell activation, differentiation, and functions. Front Immunol (2015) 1.07

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat Immunol (2015) 1.06

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy. Cell Metab (2015) 1.05

mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J Immunol (2014) 1.04

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol (2014) 0.99

The mTOR pathway and integrating immune regulation. Immunology (2013) 0.99

The rate of glycolysis quantitatively mediates specific histone acetylation sites. Cancer Metab (2015) 0.99

Is cancer a metabolic disease? Am J Pathol (2013) 0.99

Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep (2014) 0.98

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. PLoS Biol (2015) 0.98

Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS One (2014) 0.96

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. Immunity (2016) 0.96

The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages. J Biol Chem (2014) 0.96

Harnessing FOXP3+ regulatory T cells for transplantation tolerance. J Clin Invest (2014) 0.95

T-cell metabolism in autoimmune disease. Arthritis Res Ther (2015) 0.95

Modulation of T Cell Metabolism and Function through Calcium Signaling. Front Immunol (2013) 0.93

How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions? Oncogene (2014) 0.93

l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. Cancer Res (2014) 0.93

Immunometabolism: Cellular Metabolism Turns Immune Regulator. J Biol Chem (2015) 0.91

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy. Cancer Res (2015) 0.90

Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol (2015) 0.90

Biochemical signaling of PD-1 on T cells and its functional implications. Cancer J (2014) 0.89

Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. Front Oncol (2014) 0.89

Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol (2015) 0.89

Environmental and metabolic sensors that control T cell biology. Front Immunol (2015) 0.89

Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment. Front Immunol (2014) 0.89

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins. Trends Endocrinol Metab (2015) 0.88

Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nat Rev Rheumatol (2016) 0.88

Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors. Cancer Res (2014) 0.87

Dual proteolytic pathways govern glycolysis and immune competence. Cell (2014) 0.87

Promoting thiol expression increases the durability of antitumor T-cell functions. Cancer Res (2014) 0.87

TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu. Front Immunol (2013) 0.87

Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival. FASEB J (2015) 0.87

Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion. Mol Immunol (2015) 0.87

Constitutive Glycolytic Metabolism Supports CD8(+) T Cell Effector Memory Differentiation during Viral Infection. Immunity (2016) 0.86

Heterogeneity of glycolysis in cancers and therapeutic opportunities. Biochem Pharmacol (2014) 0.86

Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol (2014) 0.85

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function. J Immunol (2014) 0.85

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling. J Biol Chem (2013) 0.85

Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development. Proc Natl Acad Sci U S A (2015) 0.85

Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. Elife (2015) 0.85

D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med (2017) 0.84

The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development. Trends Parasitol (2014) 0.84

A novel model for IFN-γ-mediated autoinflammatory syndromes. J Immunol (2015) 0.84

Glycolysis determines dichotomous regulation of T cell subsets in hypoxia. J Clin Invest (2016) 0.84

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses. Cell Metab (2015) 0.84

The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection. Front Immunol (2014) 0.84

Articles cited by this

Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82

Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A (2010) 8.12

Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol (2011) 7.07

The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65

Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem (1979) 6.53

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 6.00

Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 4.78

GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell (2007) 4.22

Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res (2004) 4.03

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98

Revving the engine: signal transduction fuels T cell activation. Immunity (2007) 3.57

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol (2010) 3.08

Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase. Science (1993) 3.03

Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood (2007) 2.64

Activation of the integrated stress response during T helper cell differentiation. Nat Immunol (2006) 2.62

Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J Immunol (2005) 2.51

Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold). J Biol Chem (1995) 2.46

Metabolic flux and the regulation of mammalian cell growth. Cell Metab (2011) 2.27

The diverse functions of GAPDH: views from different subcellular compartments. Cell Signal (2010) 2.15

Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol (2010) 2.08

Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev (2012) 2.03

Metabolic pathways in T cell fate and function. Trends Immunol (2012) 1.97

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur J Immunol (2008) 1.89

The GAIT system: a gatekeeper of inflammatory gene expression. Trends Biochem Sci (2009) 1.88

Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci Transl Med (2011) 1.61

The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer. Mol Cancer Res (2008) 1.30

Glyceraldehyde-3-phosphate dehydrogenase binds to the AU-Rich 3' untranslated region of colony-stimulating factor-1 (CSF-1) messenger RNA in human ovarian cancer cells: possible role in CSF-1 posttranscriptional regulation and tumor phenotype. Cancer Res (2005) 1.25

Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability. Mol Cell Biol (2008) 1.15

Identification of the NAD(+)-binding fold of glyceraldehyde-3-phosphate dehydrogenase as a novel RNA-binding domain. Biochem Biophys Res Commun (2000) 1.10

The in vitro manipulation of carbohydrate metabolism: a new strategy for deciphering the cellular defence mechanisms against nitric oxide attack. Biochem J (1999) 1.08

Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol Cell Biol (2012) 1.07

Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells. Immunity (2011) 1.07

Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy. J Exp Med (1996) 1.05

Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production. Eur J Immunol (2008) 1.03

Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint. Mol Cell Biol (2011) 1.02

Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA. Biochem Biophys Res Commun (2011) 1.00

Hexokinase: the direct link between mitochondrial and glycolytic reactions in rapidly growing cancer cells. Adv Exp Med Biol (1978) 0.92

Articles by these authors

Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42

Helminth infections: the great neglected tropical diseases. J Clin Invest (2008) 6.92

Improved statistical tests for differential gene expression by shrinking variance components estimates. Biostatistics (2005) 5.57

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2011) 5.43

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene (2005) 4.28

MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol (2009) 4.28

Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98

Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 3.62

T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med (2009) 3.40

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35

Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74

IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol (2009) 2.74

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity (2014) 2.63

Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61

Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med (2010) 2.61

The geographic scale of metropolitan racial segregation. Demography (2008) 2.54

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. J Exp Med (2009) 2.51

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med (2006) 2.46

Regulation of pathogenesis and immunity in helminth infections. J Exp Med (2009) 2.39

Helminth antigens modulate TLR-initiated dendritic cell activation. J Immunol (2004) 2.21

Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev (2012) 2.03

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol (2004) 2.03

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. Cancer Res (2005) 2.02

PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer. Cancer Res (2009) 2.01

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol (2008) 1.93

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc Natl Acad Sci U S A (2013) 1.90

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood (2012) 1.89

Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages. Parasite Immunol (2002) 1.80

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol (2004) 1.77

Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth. Mol Biochem Parasitol (2005) 1.73

Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population. J Immunol (2006) 1.73

Nonlegumes respond to rhizobial Nod factors by suppressing the innate immune response. Science (2013) 1.72

Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol (2006) 1.72

TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni. PLoS Pathog (2007) 1.68

Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes. Cancer Res (2007) 1.65

The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol (2011) 1.62

Immunology of parasitic helminth infections. Infect Immun (2002) 1.62

Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med (2012) 1.61

Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J Immunol (2002) 1.60

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58

Race and space in the 1990s: changes in the geographic scale of racial residential segregation, 1990-2000. Soc Sci Res (2009) 1.53

Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol (2009) 1.52

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth. Cancer Biol Ther (2003) 1.52

Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses. J Immunol (2004) 1.49

Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol (2004) 1.49

Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function. Immunology (2009) 1.48

Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol (2007) 1.47

Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J Immunol (2008) 1.45

Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. J Infect Dis (2001) 1.44

Identification of a plant receptor for extracellular ATP. Science (2014) 1.44

DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Der p 2 allergen-induced allergic airway inflammation mice model. Chin Med J (Engl) (2005) 1.43

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression. J Clin Invest (2009) 1.43

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42

The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med (2015) 1.42

Single feature polymorphism discovery in rice. PLoS One (2007) 1.42

Electrocardiographic changes during vasodilator SPECT myocardial perfusion imaging: does it affect diagnosis or prognosis? J Nucl Cardiol (2011) 1.42

piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. FASEB J (2007) 1.42

Stereoselective degradation kinetics of theta-cypermethrin in rats. Environ Sci Technol (2006) 1.39

A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog (2010) 1.39

Functional plasticity in memory T helper cell responses. J Immunol (2007) 1.38

Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38

Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J (2007) 1.36

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med (2007) 1.34

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med (2012) 1.32

A comparison of costs for abdominal, laparoscopic, and robot-assisted sacral colpopexy. Int Urogynecol J Pelvic Floor Dysfunct (2008) 1.28

TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development. J Immunol (2005) 1.27

Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover. PLoS Pathog (2010) 1.26

Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells. J Immunol (2002) 1.26

Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. J Clin Invest (2012) 1.21

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. J Immunol (2012) 1.18

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B. J Immunol (2007) 1.18

Genetic manipulation of schistosomes. Int J Parasitol (2007) 1.17