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Protein misfolding and aggregation in cataract disease and prospects for prevention. Trends Mol Med (2012) 1.52

Very few substitutions in a germ line antibody are required to initiate significant domain exchange. J Virol (2010) 1.41

Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins. Nature (2011) 1.37

Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proc Natl Acad Sci U S A (2010) 1.35

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A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell (2012) 1.23

β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol (2010) 1.22

Dynamics of locking of peptides onto growing amyloid fibrils. Proc Natl Acad Sci U S A (2009) 1.15

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Protein reconstitution and three-dimensional domain swapping: benefits and constraints of covalency. Protein Sci (2007) 1.08

Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. EMBO J (2009) 1.07

Frustration in the energy landscapes of multidomain protein misfolding. Proc Natl Acad Sci U S A (2013) 1.06

Cytochrome c polymerization by successive domain swapping at the C-terminal helix. Proc Natl Acad Sci U S A (2010) 1.01

The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer. Protein Sci (2010) 0.94

Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin. Protein Sci (2010) 0.93

Domain swapping and amyloid fibril conformation. Prion (2012) 0.93

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Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires. Proc Natl Acad Sci U S A (2010) 0.91

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Left handed beta helix models for mammalian prion fibrils. Prion (2008) 0.87

Foldon unfolding mediates the interconversion between M(pro)-C monomer and 3D domain-swapped dimer. Proc Natl Acad Sci U S A (2012) 0.86

Proline is not uniquely capable of providing the pivot point for domain swapping in 2G12, a broadly neutralizing antibody against HIV-1. J Biol Chem (2009) 0.85

Domain metastability: a molecular basis for immunoglobulin deposition? J Mol Biol (2010) 0.85

Protein aggregation in silico. Trends Biotechnol (2007) 0.85

A structural overview of the vertebrate prion proteins. Prion (2007) 0.84

Amyloid-like fibrils from a domain-swapping protein feature a parallel, in-register conformation without native-like interactions. J Biol Chem (2011) 0.84

Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci (2012) 0.83

Learning To Fold Proteins Using Energy Landscape Theory. Isr J Chem (2014) 0.83

Structure of the phosphatase domain of the cell fate determinant SpoIIE from Bacillus subtilis. J Mol Biol (2011) 0.83

Engineering domain-swapped binding interfaces by mutually exclusive folding. J Mol Biol (2012) 0.83

Domain swapping in allosteric modulation of DNA specificity. PLoS Biol (2010) 0.83

Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL. J Lipid Res (2015) 0.83

Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities. PLoS One (2012) 0.82

Propensity for C-terminal domain swapping correlates with increased regional flexibility in the C-terminus of RNase A. Protein Sci (2011) 0.82

Functional repertoire, molecular pathways and diseases associated with 3D domain swapping in the human proteome. J Clin Bioinforma (2012) 0.82

Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor. Nat Struct Mol Biol (2016) 0.81

Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor. Arch Biochem Biophys (2012) 0.81

Change in structure and ligand binding properties of hyperstable cytochrome c555 from Aquifex aeolicus by domain swapping. Protein Sci (2015) 0.80

Anisotropy of the Coulomb interaction between folded proteins: consequences for mesoscopic aggregation of lysozyme. Biophys J (2012) 0.80

Insights into Protein Sequence and Structure-Derived Features Mediating 3D Domain Swapping Mechanism using Support Vector Machine Based Approach. Bioinform Biol Insights (2010) 0.79

Minimum energy compact structures in force-quench polyubiquitin folding are domain swapped. Proc Natl Acad Sci U S A (2011) 0.79

The Landscape of Intertwined Associations in Homooligomeric Proteins. Biophys J (2015) 0.78

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. Nat Commun (2015) 0.78

Interaction of dimeric horse cytochrome c with cyanide ion. J Biol Inorg Chem (2013) 0.78

Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem (2014) 0.78

Wild-type human γD-crystallin promotes aggregation of its oxidation-mimicking, misfolding-prone W42Q mutant. J Biol Chem (2015) 0.78

Engineered Domain Swapping as an On/Off Switch for Protein Function. Chem Biol (2015) 0.77

Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation. PLoS One (2014) 0.77

Domain-swapped cytochrome cb562 dimer and its nanocage encapsulating a Zn-SO4 cluster in the internal cavity. Chem Sci (2015) 0.77

New insight into serpin polymerization and aggregation. Prion (2009) 0.76

Nucleation precursors in protein crystallization. Acta Crystallogr F Struct Biol Commun (2014) 0.76

Structural insights into the intertwined dimer of fyn SH2. Protein Sci (2015) 0.76

Assignment-free solution NMR method reveals CesT as an unswapped homodimer. Protein Sci (2008) 0.76

Fertility defects in mice expressing the L68Q variant of human cystatin C: a role for amyloid in male infertility. J Biol Chem (2014) 0.76

Genome-Wide Prediction and Analysis of 3D-Domain Swapped Proteins in the Human Genome from Sequence Information. PLoS One (2016) 0.75

Prediction and Reduction of the Aggregation of Monoclonal Antibodies. J Mol Biol (2017) 0.75

NMR studies on structure and dynamics of the monomeric derivative of BS-RNase: new insights for 3D domain swapping. PLoS One (2012) 0.75

The impact of solubility and electrostatics on fibril formation by the H3 and H4 histones. Protein Sci (2011) 0.75

Formation and Carbon Monoxide-Dependent Dissociation of Allochromatium vinosum Cytochrome c' Oligomers Using Domain-Swapped Dimers. Protein Sci (2016) 0.75

Effect of methionine80 heme coordination on domain swapping of cytochrome c. J Biol Inorg Chem (2017) 0.75

MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors. PLoS One (2017) 0.75

The Database of Interacting Proteins: 2004 update. Nucleic Acids Res (2004) 23.67

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res (2002) 15.70

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99

Structure of the cross-beta spine of amyloid-like fibrils. Nature (2005) 11.56

Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature (2007) 10.02

The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24

Protein interactions: two methods for assessment of the reliability of high throughput observations. Mol Cell Proteomics (2002) 8.11

Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol (2007) 8.03

Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 7.29

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83

The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A (2003) 5.83

PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01

3D domain swapping: as domains continue to swap. Protein Sci (2002) 4.35

Prolinks: a database of protein functional linkages derived from coevolution. Genome Biol (2004) 4.07

Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78

Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci U S A (2010) 3.50

The origin of protein interactions and allostery in colocalization. Nature (2007) 3.34

Protein structures forming the shell of primitive bacterial organelles. Science (2005) 3.20

Atomic view of a toxic amyloid small oligomer. Science (2012) 3.13

Continuation and satisfaction of reversible contraception. Obstet Gynecol (2011) 3.03

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure. Nature (2005) 2.99

An architectural framework that may lie at the core of the postsynaptic density. Science (2006) 2.91

Inference of protein function from protein structure. Structure (2005) 2.90

The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A (2006) 2.88

Computational methods of analysis of protein-protein interactions. Curr Opin Struct Biol (2003) 2.80

Describing biological protein interactions in terms of protein states and state transitions: the LiveDIP database. Mol Cell Proteomics (2002) 2.76

Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci (2007) 2.57

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46

Structure and mechanisms of a protein-based organelle in Escherichia coli. Science (2010) 2.45

Atomic-level models of the bacterial carboxysome shell. Science (2008) 2.36

Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science (2012) 2.33

Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis. Infect Immun (2006) 2.27

Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiol (2003) 2.25

Dimerization allows DNA target site recognition by the NarL response regulator. Nat Struct Biol (2002) 2.05

Recent atomic models of amyloid fibril structure. Curr Opin Struct Biol (2006) 2.05

Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol (2003) 2.04

Ethical considerations of complementary and alternative medical therapies in conventional medical settings. Ann Intern Med (2002) 2.02

The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell (2003) 1.99

Inferring protein domain interactions from databases of interacting proteins. Genome Biol (2005) 1.97

Crystal structure of human fibrinogen. Biochemistry (2009) 1.97

A specific secretion system mediates PPE41 transport in pathogenic mycobacteria. Mol Microbiol (2006) 1.97

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci (2010) 1.95

Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol (2009) 1.94

Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci (2008) 1.89

Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci U S A (2008) 1.86

Use of logic relationships to decipher protein network organization. Science (2004) 1.86

An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril. Proc Natl Acad Sci U S A (2004) 1.85

GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles. Biochemistry (2002) 1.82

Genomic evidence that the intracellular proteins of archaeal microbes contain disulfide bonds. Proc Natl Acad Sci U S A (2002) 1.81

Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A (2011) 1.76

In silico simulation of biological network dynamics. Nat Biotechnol (2004) 1.74

GXXXG and GXXXA motifs stabilize FAD and NAD(P)-binding Rossmann folds through C(alpha)-H... O hydrogen bonds and van der waals interactions. J Mol Biol (2002) 1.74

Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science (2003) 1.73

Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci U S A (2011) 1.71

Bacterial inclusion bodies contain amyloid-like structure. PLoS Biol (2008) 1.63

Cross-beta order and diversity in nanocrystals of an amyloid-forming peptide. J Mol Biol (2003) 1.59

Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Cell (2004) 1.59

Towards a pharmacophore for amyloid. PLoS Biol (2011) 1.58

Structural analysis of CsoS1A and the protein shell of the Halothiobacillus neapolitanus carboxysome. PLoS Biol (2007) 1.57

Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest (2008) 1.54

The crystal structure of a cyanobacterial water-soluble carotenoid binding protein. Structure (2003) 1.54

Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A (2012) 1.53

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem (2008) 1.49

Structural models of amyloid-like fibrils. Adv Protein Chem (2006) 1.49

A systematic screen of beta(2)-microglobulin and insulin for amyloid-like segments. Proc Natl Acad Sci U S A (2006) 1.49

The MiSink Plugin: Cytoscape as a graphical interface to the Database of Interacting Proteins. Bioinformatics (2007) 1.49

A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell (2008) 1.48

Structure and folding of a designed knotted protein. Proc Natl Acad Sci U S A (2010) 1.48

The structural biology of protein aggregation diseases: Fundamental questions and some answers. Acc Chem Res (2006) 1.47

Molecular basis for insulin fibril assembly. Proc Natl Acad Sci U S A (2009) 1.47

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. Protein Sci (2009) 1.46

Seeded conversion of recombinant prion protein to a disulfide-bonded oligomer by a reduction-oxidation process. Nat Struct Biol (2003) 1.46

Recurated protein interaction datasets. Nat Methods (2009) 1.43

Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J Mol Biol (2004) 1.43

The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif. J Biol Chem (2006) 1.42

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A (2012) 1.39

Cooperative hydrogen bonding in amyloid formation. Protein Sci (2007) 1.33

Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition. Proc Natl Acad Sci U S A (2011) 1.33

Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps. Nucleic Acids Res (2003) 1.31

Short protein segments can drive a non-fibrillizing protein into the amyloid state. Protein Eng Des Sel (2009) 1.31

Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol (2003) 1.30