Ubx2 links the Cdc48 complex to ER-associated protein degradation.

One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol (2008) 4.54

Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90

Protein quality control in the early secretory pathway. EMBO J (2008) 3.59

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell (2008) 3.41

The ubiquitylation machinery of the endoplasmic reticulum. Nature (2009) 2.66

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J (2006) 2.58

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2008) 2.38

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol (2006) 2.13

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin Cell Dev Biol (2007) 2.13

Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Cell Cycle (2010) 2.08

Inhibition of p97-dependent protein degradation by Eeyarestatin I. J Biol Chem (2008) 2.07

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell (2009) 1.94

Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell (2011) 1.91

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. EMBO J (2006) 1.83

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol Cell (2009) 1.82

Quality control: ER-associated degradation: protein quality control and beyond. J Cell Biol (2014) 1.75

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems. Curr Opin Cell Biol (2011) 1.74

The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73

Quality and quantity control at the endoplasmic reticulum. Curr Opin Cell Biol (2010) 1.42

Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery. J Biol Chem (2008) 1.39

Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell (2014) 1.35

In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem (2009) 1.31

Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold. Biol Direct (2007) 1.31

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. J Biol Chem (2008) 1.27

The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A (2006) 1.26

p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation. EMBO J (2006) 1.24

Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol (2013) 1.20

The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell (2010) 1.17

The activities and function of molecular chaperones in the endoplasmic reticulum. Semin Cell Dev Biol (2007) 1.16

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Proc Natl Acad Sci U S A (2009) 1.15

Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy. Cell Res (2011) 1.07

Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem (2011) 1.07

A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell (2013) 1.02

Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. J Biol Chem (2011) 0.98

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase. J Biol Chem (2013) 0.98

How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD. Biochim Biophys Acta (2013) 0.96

p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association? Genes Cancer (2010) 0.96

Identification of an Htm1 (EDEM)-dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD. J Biol Chem (2010) 0.95

Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin. Cells (2014) 0.95

The endoplasmic reticulum-associated degradation pathways of budding yeast. Cold Spring Harb Perspect Biol (2012) 0.95

Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J Biol Chem (2013) 0.94

Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94

Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum. Mol Biol Cell (2011) 0.93

Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem (2009) 0.93

Three old and one new: protein import into red algal-derived plastids surrounded by four membranes. Protoplasma (2013) 0.93

Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92

Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol Biol Cell (2009) 0.92

ERAD and how viruses exploit it. Front Microbiol (2014) 0.91

Endoplasmic reticulum-mediated protein quality control in Arabidopsis. Front Plant Sci (2014) 0.91

A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem (2010) 0.90

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet (2016) 0.89

Importin beta interacts with the endoplasmic reticulum-associated degradation machinery and promotes ubiquitination and degradation of mutant alpha1-antitrypsin. J Biol Chem (2011) 0.87

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett (2008) 0.87

A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem (2013) 0.86

Protein quality control: the who's who, the where's and therapeutic escapes. Histochem Cell Biol (2007) 0.85

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun (2016) 0.84

Doa1 targets ubiquitinated substrates for mitochondria-associated degradation. J Cell Biol (2016) 0.84

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation. Mol Biol Cell (2013) 0.83

A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells. BMC Genomics (2009) 0.82

Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex. J Biol Chem (2012) 0.82

Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front Genet (2016) 0.81

Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2. J Biol Chem (2014) 0.80

Recent technical developments in the study of ER-associated degradation. Curr Opin Cell Biol (2014) 0.80

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins. Mol Biol Cell (2014) 0.80

The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). PLoS One (2013) 0.77

Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis. PLoS Genet (2014) 0.77

Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation. Sci Rep (2015) 0.76

Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene. PLoS One (2012) 0.76

Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation. PLoS One (2016) 0.76

Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO. PLoS One (2013) 0.76

The natural diyne-furan fatty acid EV-086 is an inhibitor of fungal delta-9 fatty acid desaturation with efficacy in a model of skin dermatophytosis. Antimicrob Agents Chemother (2013) 0.75

Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane. J Biol Chem (2016) 0.75

Computational Analysis of Host-Pathogen Protein Interactions between Humans and Different Strains of Enterohemorrhagic Escherichia coli. Front Cell Infect Microbiol (2017) 0.75

A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation. J Biol Chem (2016) 0.75

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun (2016) 0.75

A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation. Sci Rep (2017) 0.75

Toward an understanding of the Cdc48/p97 ATPase. F1000Res (2017) 0.75

ERAD: the long road to destruction. Nat Cell Biol (2005) 7.46

Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med (2008) 6.80

Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol (2002) 5.02

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06

Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol Cell (2010) 3.23

The ubiquitylation machinery of the endoplasmic reticulum. Nature (2009) 2.66

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery. Nat Cell Biol (2006) 2.41

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum. J Cell Biol (2009) 1.93

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. EMBO J (2006) 1.83

The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73

High uptake of exclusive breastfeeding and reduced early post-natal HIV transmission. PLoS One (2007) 1.62

Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol Cell (2009) 1.58

New modules for the repeated internal and N-terminal epitope tagging of genes in Saccharomyces cerevisiae. Yeast (2005) 1.57

Protein dislocation from the ER. Biochim Biophys Acta (2010) 1.43

A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast. J Biol Chem (2002) 1.31

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Mol Cell (2012) 1.30

In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity. Mol Cell Biol (2004) 1.29

Nuclear localization signal and protein context both mediate importin alpha specificity of nuclear import substrates. Mol Cell Biol (2006) 1.29

Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim Biophys Acta (2013) 1.28

A role for mammalian Ubc6 homologues in ER-associated protein degradation. J Cell Sci (2002) 1.26

Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation. Mol Cell (2004) 1.23

Finding the will and the way of ERAD substrate retrotranslocation. Curr Opin Cell Biol (2012) 1.16

Endoplasmic reticulum-associated protein degradation. Int Rev Cytol (2003) 1.16

Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission. PLoS One (2010) 1.13

Protein dislocation from the endoplasmic reticulum--pulling out the suspect. Traffic (2002) 1.12

Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization. EMBO J (2005) 1.11

Endoplasmic reticulum-associated protein degradation--one model fits all? Biochim Biophys Acta (2004) 1.10

ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum. Bioessays (2010) 1.08

Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected women. Pediatrics (2009) 1.06

CT-navigation versus fluoroscopy-guided placement of pedicle screws at the thoracolumbar spine: single center experience of 4,500 screws. Eur Spine J (2012) 1.05

Coping with stress: cellular relaxation techniques. Trends Cell Biol (2006) 0.97

BiP binding keeps ATF6 at bay. Dev Cell (2002) 0.95

Risk factors of aseptic bone resorption: a study after autologous bone flap reinsertion due to decompressive craniotomy. J Neurosurg (2013) 0.92

Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis. J Neurooncol (2014) 0.91

4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms. PLoS One (2010) 0.91

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Mol Cell (2013) 0.88

GluR- and TrkB-mediated maturation of GABA receptor function during the period of eye opening. Eur J Neurosci (2005) 0.88

Anterior cervical intercorporal fusion in patients with osteoporotic or tumorous fractures using a cement augmented cervical plate system: first results of a prospective single-center study. J Spinal Disord Tech (2013) 0.87

Protein quality control: on IPODs and other JUNQ. Curr Biol (2008) 0.86

Smoking history and the incidence of age-related macular degeneration--results from the Muenster Aging and Retina Study (MARS) cohort and systematic review and meta-analysis of observational longitudinal studies. Addict Behav (2009) 0.86

Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast. Mol Cell Biol (2008) 0.85

The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore. Angew Chem Int Ed Engl (2012) 0.85

Major outbreak of hepatitis A associated with orange juice among tourists, Egypt, 2004. Emerg Infect Dis (2007) 0.85

HIV-1 concentrations in human breast milk before and after weaning. Sci Transl Med (2013) 0.84

Structural and biochemical basis of Yos9 protein dimerization and possible contribution to self-association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation ubiquitin-ligase complex. J Biol Chem (2012) 0.82

Cerebral metastasis of a primary heart sarcoma. Neurol Neurochir Pol (2010) 0.81

Expandable titanium cages for anterior column cervical reconstruction and their effect on sagittal profile: a review of 48 cases. Acta Neurochir (Wien) (2013) 0.80

Cerebral abscess due to Lactococcus lactis cremoris in a child after sinusitis. Clin Neurol Neurosurg (2012) 0.80

Denervation and atrophy of paraspinal muscles after open lumbar interbody fusion is associated with clinical outcome--electromyographic and CT-volumetric investigation of 30 patients. Acta Neurochir (Wien) (2014) 0.80

Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases. J Cancer Res Clin Oncol (2010) 0.79

Multiplanar MRI-CT fusion neuronavigation-guided serial stereotactic biopsy of human brain tumors: proof of a strong correlation between tumor imaging and histopathology by a new technical approach. J Cancer Res Clin Oncol (2009) 0.78

Selection of suitable reference genes for expression analysis in human glioma using RT-qPCR. J Neurooncol (2015) 0.77

Pardon me--no access without ubiquitin. Dev Cell (2005) 0.76

Death gives birth to life: the essential role of the ubiquitin-proteasome system in biology. Biochim Biophys Acta (2004) 0.76

Large outbreak of hepatitis A in tourists staying at a hotel in Hurghada, Egypt, 2004--orange juice implicated. Euro Surveill (2005) 0.76

Methylation-specific multiplex ligation-dependent probe amplification and its impact on clinical findings in medulloblastoma. J Neurooncol (2013) 0.76

Bone flap necrosis after decompressive hemicraniectomy for malignant middle cerebral artery infarction. Neurocrit Care (2014) 0.75

Varshavsky's contributions. Science (2004) 0.75

Parafalcine mass with meningothelial and chondroid features. Clin Neuropathol (2015) 0.75