Published in Proc Natl Acad Sci U S A on February 21, 2012
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol (2013) 1.65
Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A (2015) 0.97
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. Proc Natl Acad Sci U S A (2012) 0.93
Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine. J Mol Biol (2015) 0.84
Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. ACS Med Chem Lett (2015) 0.84
Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy. Open Biol (2014) 0.84
Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor. Acta Crystallogr D Biol Crystallogr (2014) 0.84
Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication. Chromosoma (2016) 0.81
Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine. J Biol Chem (2013) 0.81
Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain. Sci Rep (2016) 0.80
The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97. Front Mol Biosci (2017) 0.79
The role of the N-D1 linker of the N-ethylmaleimide-sensitive factor in the SNARE disassembly. PLoS One (2013) 0.77
Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding. Chembiochem (2016) 0.76
Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell. BMC Evol Biol (2016) 0.75
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell (2000) 3.97
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Nat Cell Biol (2001) 3.67
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell (2001) 3.62
Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes. Cell (1995) 3.44
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat Struct Biol (2003) 2.93
Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression. J Cell Biol (1991) 2.79
An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF. EMBO J (1990) 2.60
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nat Struct Biol (2002) 2.38
Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure (2008) 2.36
Nucleotide dependent motion and mechanism of action of p97/VCP. J Mol Biol (2005) 2.31
Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases. J Struct Biol (2004) 2.15
Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J Biol Chem (2002) 2.01
Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH. J Biol Chem (1999) 1.97
Use of a cDNA clone to identify a supposed precursor protein containing valosin. Nature (1987) 1.90
Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin Cell Dev Biol (2007) 1.88
The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol Biol Cell (2001) 1.66
ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity. J Biol Chem (2002) 1.66
Going through the motions: the ATPase cycle of p97. J Struct Biol (2006) 1.61
VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J Cell Biol (2004) 1.55
Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine. J Biol Chem (2003) 1.39
Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities. Biochem Biophys Res Commun (2003) 1.38
MgATP binding and hydrolysis determinants of NtrC, a bacterial enhancer-binding protein. J Bacteriol (1999) 1.38
The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A (2006) 1.26
Role(s) of Cdc48/p97 in mitosis. Biochem Soc Trans (2008) 1.23
D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP. J Biol Chem (2003) 1.22
p97/p47-Mediated biogenesis of Golgi and ER. J Biochem (2005) 1.21
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A (2007) 1.21
The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
NSF/SNAPs and p97/p47/VCIP135 are sequentially required for cell cycle-dependent reformation of the ER network. Genes Cells (2005) 1.04
Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding. Mol Cell Biol (2011) 1.02
New ATPase regulators--p97 goes to the PUB. Int J Biochem Cell Biol (2009) 1.02
Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation. J Neurosci (2010) 0.97
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab (2006) 4.64
A comparative anatomic study of a modified temporal-occipital transtentorial transpetrosal-ridge approach and a transpetrosal presigmoid approach. World Neurosurg (2011) 3.30
Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo. Nature (2004) 2.69
The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell (2006) 2.31
The prevalence and burden of primary headaches in China: a population-based door-to-door survey. Headache (2012) 2.04
Studies on the function of oligosaccharyl transferase subunits. Stt3p is directly involved in the glycosylation process. J Biol Chem (2002) 1.80
The burden of headache in China: validation of diagnostic questionnaire for a population-based survey. J Headache Pain (2011) 1.67
Unraveling the mechanism of protein N-glycosylation. J Biol Chem (2004) 1.61
Rosuvastatin attenuates the elevation in blood pressure induced by overexpression of human C-reactive protein. Hypertens Res (2011) 1.50
Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: role of mitochondrial permeability transition. Crit Care Med (2012) 1.48
Mediation of multiple pathways regulating cell proliferation, migration, and apoptosis in the human malignant glioma cell line U87MG via unphosphorylated STAT1: laboratory investigation. J Neurosurg (2013) 1.44
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett (2003) 1.42
Expression of snail in pancreatic cancer promotes metastasis and chemoresistance. J Surg Res (2007) 1.40
Value of myocardial regional perfusion on long-term function in collateral-dependent myocardium. South Med J (2008) 1.40
Cytoplasmic peptide:N-glycanase (PNGase) in eukaryotic cells: occurrence, primary structure, and potential functions. FASEB J (2002) 1.33
Obstructive sleep apnea and risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective cohort studies. Int J Cardiol (2013) 1.29
The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A (2006) 1.26
Overexpression of high-mobility group box 1 correlates with tumor progression and poor prognosis in human colorectal carcinoma. J Cancer Res Clin Oncol (2009) 1.26
Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons. Neurosci Res (2009) 1.23
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A (2007) 1.21
Reactivity and chemical synthesis of L-pyrrolysine- the 22(nd) genetically encoded amino acid. Chem Biol (2004) 1.19
Persistence of side population cells with high drug efflux capacity in pancreatic cancer. World J Gastroenterol (2008) 1.18
A meta-analysis of gemcitabine containing chemotherapy for locally advanced and metastatic pancreatic adenocarcinoma. J Hematol Oncol (2011) 1.15
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2013) 1.13
The catalytic activity of protein-disulfide isomerase requires a conformationally flexible molecule. J Biol Chem (2008) 1.12
Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats. Neurochem Int (2010) 1.11
Asymmetric [3+2] cycloadditions of allenoates and dual activated olefins catalyzed by simple bifunctional N-acyl aminophosphines. Angew Chem Int Ed Engl (2010) 1.10
Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol. Proc Natl Acad Sci U S A (2002) 1.10
Structure of the oligosaccharyl transferase complex at 12 A resolution. Structure (2008) 1.10
Specificity of pyrrolysyl-tRNA synthetase for pyrrolysine and pyrrolysine analogs. J Mol Biol (2008) 1.08
Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice. Neuropharmacology (2011) 1.07
Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeys. Arterioscler Thromb Vasc Biol (2007) 1.07
An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation. Proc Natl Acad Sci U S A (2009) 1.06
Body mass index and migraine: a survey of the Chinese adult population. J Headache Pain (2012) 1.06
microRNA-181a represses ox-LDL-stimulated inflammatory response in dendritic cell by targeting c-Fos. J Lipid Res (2012) 1.05
Headache yesterday in China: a new approach to estimating the burden of headache, applied in a general-population survey in China. Cephalalgia (2013) 1.04
A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2004) 1.04
Meta-modeling soil organic carbon sequestration potential and its application at regional scale. Ecol Appl (2013) 1.03
Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2003) 1.02
Nonlinear optical microscopy for histology of fresh normal and cancerous pancreatic tissues. PLoS One (2012) 1.02
Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons. Glycobiology (2005) 1.02
Dimeric organization of the yeast oligosaccharyl transferase complex. Proc Natl Acad Sci U S A (2006) 1.02
The accuracy of survival time prediction for patients with glioma is improved by measuring mitotic spindle checkpoint gene expression. PLoS One (2011) 1.02
Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module. Proc Natl Acad Sci U S A (2006) 1.01
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology (2012) 1.01
Pharmacokinetics and tissue distribution of PGG-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts. Cancer Chemother Pharmacol (2009) 1.01
Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J Biol Chem (2006) 1.01
Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine. Int J Mol Sci (2011) 1.00
Site-directed mutagenesis study of yeast peptide:N-glycanase. Insight into the reaction mechanism of deglycosylation. J Biol Chem (2002) 0.99
Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel. J Control Release (2009) 0.99
Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane. Cancer Chemother Pharmacol (2009) 0.99
Misfolding of glycoproteins is a prerequisite for peptide: N-glycanase mediated deglycosylation. FEBS Lett (2005) 0.98
The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies. BMC Gastroenterol (2014) 0.98
The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum. Mol Biol Cell (2005) 0.98
Subunits of the translocon interact with components of the oligosaccharyl transferase complex. J Biol Chem (2005) 0.97
Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res (2004) 0.96
The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. J Alzheimers Dis (2013) 0.96
Catheter-based adenovirus-mediated anti-monocyte chemoattractant gene therapy attenuates in-stent neointima formation in cynomolgus monkeys. Atherosclerosis (2006) 0.95
Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents. Hepatology (2013) 0.95
Structural basis for the function of a minimembrane protein subunit of yeast oligosaccharyltransferase. Proc Natl Acad Sci U S A (2004) 0.95
Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. Neurotherapeutics (2011) 0.95
A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Mycobacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid. J Clin Microbiol (2012) 0.95
Health-care utilization for primary headache disorders in China: a population-based door-to-door survey. J Headache Pain (2013) 0.94
Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. J Med Chem (2012) 0.94
Bifunctional N-acyl-aminophosphine-catalyzed asymmetric [4+2] cycloadditions of allenoates and imines. Chemistry (2011) 0.94
Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2. Microb Pathog (2009) 0.94
Oligosaccharyltransferase directly binds to ribosome at a location near the translocon-binding site. Proc Natl Acad Sci U S A (2009) 0.94
Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. JACC Cardiovasc Interv (2009) 0.93
Spontaneous differentiation of murine bone marrow-derived mesenchymal stem cells into adipocytes without malignant transformation after long-term culture. Cells Tissues Organs (2009) 0.93
An efficient and enantioselective approach to the azaspirocyclic core of alkaloids: formal synthesis of halichlorine and pinnaic acid. J Org Chem (2005) 0.93
Rickettsia raoultii, the predominant Rickettsia found in Dermacentor silvarum ticks in China-Russia border areas. Exp Appl Acarol (2014) 0.93
Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. Proc Natl Acad Sci U S A (2012) 0.93
MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway. Cell Cycle (2015) 0.92
Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways. Pancreatology (2013) 0.92
Ngly1, a mouse gene encoding a deglycosylating enzyme implicated in proteasomal degradation: expression, genomic organization, and chromosomal mapping. Biochem Biophys Res Commun (2003) 0.92
Use of 3D-computed tomography angiography for planning the surgical removal of pineal region meningiomas using Poppen's approach: a report of ten cases and a literature review. World J Surg Oncol (2011) 0.92
Synergistic effect of the combination of nanoparticulate Fe3O4 and Au with daunomycin on K562/A02 cells. Int J Nanomedicine (2008) 0.92
Probing the structure and function of human glutaminase-interacting protein: a possible target for drug design. Biochemistry (2008) 0.91
Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation. Behav Brain Res (2010) 0.91
Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase. Glycobiology (2008) 0.90
Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide. Biol Pharm Bull (2008) 0.90
Abernethy malformation with multiple aneurysms: incidentally found in an adult woman with Caroli's disease. Ann Hepatol (2013) 0.90
Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice. Prostaglandins Other Lipid Mediat (2011) 0.90
Topiramate reduced sweat secretion and aquaporin-5 expression in sweat glands of mice. Life Sci (2007) 0.90
Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line. J Hepatol (2002) 0.90
Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes. PLoS One (2012) 0.90
Pancreaticoduodenectomy with vascular resection for local advanced pancreatic head cancer: a single center retrospective study. J Gastrointest Surg (2008) 0.90
Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex. J Cell Mol Med (2012) 0.90
High RIN1 expression is associated with poor prognosis in patients with gastric adenocarcinoma. Tumour Biol (2012) 0.89
The Arabidopsis AtPNG1 gene encodes a peptide: N-glycanase. Plant J (2007) 0.89
Tyrosine phosphorylation of ATPase p97 regulates its activity during ERAD. Biochem Biophys Res Commun (2008) 0.89
Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats. World J Gastroenterol (2006) 0.89
Hypothesis: a glycoprotein-degradation complex formed by protein-protein interaction involves cytoplasmic peptide:N-glycanase. Biochem Biophys Res Commun (2003) 0.89
Et2Zn-catalyzed intramolecular hydroamination of alkynyl sulfonamides and the related tandem cyclization/addition reaction. J Org Chem (2007) 0.89
A cytoplasmic peptide: N-glycanase. Methods Enzymol (2006) 0.89
Structural studies and the assembly of the heptameric post-translational translocon complex. J Biol Chem (2010) 0.89