Published in Crit Care Med on July 01, 2006
"Spicing up" of the immune system by curcumin. J Clin Immunol (2007) 2.43
Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Crit Care Med (2009) 1.55
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochem Pharmacol (2014) 1.47
Meeting the challenge of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2009) 1.22
Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol (2013) 1.21
Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res (2007) 1.19
Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity. PLoS One (2008) 1.11
Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis. Gut (2006) 1.03
The antioxidant response element and oxidative stress modifiers in airway diseases. Curr Mol Med (2008) 0.94
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. Malar J (2011) 0.91
Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation (2010) 0.89
Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model. Lab Invest (2008) 0.89
Preventive action of curcumin in experimental acute pancreatitis in mouse. Indian J Med Res (2011) 0.89
Novel synthetic biscoumarins target tumor necrosis factor-α in hepatocellular carcinoma in vitro and in vivo. J Biol Chem (2014) 0.88
Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. Pharmacol Rev (2014) 0.87
The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis. Mediators Inflamm (2008) 0.87
Curcumin is not a ligand for peroxisome proliferator-activated receptor-γ Gene Ther Mol Biol (2009) 0.85
Peroxisome proliferator activated receptor-γ and traumatic brain injury. Int J Clin Exp Med (2010) 0.84
Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both? Curr Heart Fail Rep (2015) 0.84
Pilot study of oral administration of a curcumin-phospholipid formulation for treatment of central serous chorioretinopathy. Clin Ophthalmol (2012) 0.83
Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases. PPAR Res (2012) 0.83
Curcumin and muscle wasting: a new role for an old drug? Nutrition (2008) 0.83
Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2009) 0.82
Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions. Curr Neuropharmacol (2007) 0.82
Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol (2010) 0.81
Novel Therapeutic Agents in Pediatric Sepsis: Peroxisome Proliferator Receptor γ (PPAR γ) Agonists. Open Inflamm J (2011) 0.80
The spice of life: curcumin reduces the mortality associated with experimental sepsis. Crit Care Med (2006) 0.80
Lipid Use and Misuse by the Heart. Circ Res (2016) 0.79
The impact of chronic kidney disease and short-term treatment with rosiglitazone on plasma cell-free DNA levels. PPAR Res (2014) 0.79
Pre-germinated brown rice prevents high-fat diet induced hyperglycemia through elevated insulin secretion and glucose metabolism pathway in C57BL/6J strain mice. J Clin Biochem Nutr (2014) 0.78
A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators. Inflammation (2012) 0.77
Oral administration of a curcumin-phospholipid delivery system for the treatment of central serous chorioretinopathy: a 12-month follow-up study. Clin Ophthalmol (2013) 0.77
Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock. Cytokine (2015) 0.76
Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice. World J Gastroenterol (2011) 0.76
Novel therapeutic approach for the treatment of periodontitis by curcumin. J Clin Diagn Res (2014) 0.76
Crystal structures of 3,5-bis-[(E)-3-hy-droxy-benzyl-idene]-1-methyl-piperidin-4-one and 3,5-bis-[(E)-2-chloro-benzyl-idene]-1-methyl-piperidin-4-one. Acta Crystallogr E Crystallogr Commun (2015) 0.75
Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products. Evid Based Complement Alternat Med (2013) 0.75
Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-α: a randomized placebo-controlled double-blind clinical trial. Immunol Res (2017) 0.75
Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice. Food Nutr Res (2017) 0.75
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61
A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (2002) 3.58
Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr (2007) 3.45
Poly[bis[aquaneodymium(III)]-mu2-oxalato-di-mu4-succinato]. Acta Crystallogr C (2007) 2.84
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med (2007) 2.48
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47
A phase diagram for jammed matter. Nature (2008) 2.45
The effect of intraoperative rectal washout on local recurrence after rectal cancer surgery: a meta-analysis. Ann Surg Oncol (2012) 2.38
Cortical actin turnover during cytokinesis requires myosin II. Curr Biol (2005) 2.30
Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex. Cereb Cortex (2006) 2.28
Adenosine A2A receptor activation: another potential therapy for trauma and hemorrhagic shock. Crit Care Med (2006) 2.18
A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13
Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res (2006) 2.12
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell (2008) 2.12
Endoscopic submucosal dissection for treatment of esophageal submucosal tumors originating from the muscularis propria layer. Gastrointest Endosc (2011) 2.08
A 70-year-old man with blue skin. Clin Chem (2014) 2.03
Structural insights into the YAP and TEAD complex. Genes Dev (2010) 2.00
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology (2008) 1.97
Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med (2005) 1.93
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev (2013) 1.91
Cortical layer-dependent BOLD and CBV responses measured by spin-echo and gradient-echo fMRI: insights into hemodynamic regulation. Neuroimage (2006) 1.90
Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A (2005) 1.88
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87
Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999-2006. Obes Surg (2011) 1.85
Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem (2003) 1.82
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature (2008) 1.79
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Am J Pathol (2002) 1.78
Antiangiogenic properties of gold nanoparticles. Clin Cancer Res (2005) 1.78
A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester. J Immunol Methods (2009) 1.78
Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. Curr Med Res Opin (2011) 1.77
Improved spatial localization of post-stimulus BOLD undershoot relative to positive BOLD. Neuroimage (2006) 1.76
Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression. Mol Cell (2012) 1.76
PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell (2010) 1.75
The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron (2010) 1.74
Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol (2009) 1.71
Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation. PLoS One (2010) 1.70
MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T. Magn Reson Med (2012) 1.67
Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit Care Med (2009) 1.67
Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med (2005) 1.66
Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest (2003) 1.66
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res (2013) 1.61
A review of statistical methods for expression quantitative trait loci mapping. Mamm Genome (2006) 1.60
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol (2007) 1.60
Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med (2002) 1.60
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera. Genetics (2011) 1.60
Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ Health Perspect (2006) 1.60
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci (2008) 1.60
Evaluation of the human transmission risk of an atypical bovine spongiform encephalopathy prion strain. J Virol (2008) 1.59
Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice. Crit Care Med (2011) 1.58
Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa. Biochem J (2011) 1.57
Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation. J Lab Clin Med (2004) 1.57
C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. Proc Natl Acad Sci U S A (2002) 1.56
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep (2005) 1.56
Adipocyte extracellular matrix composition, dynamics and role in obesity. Cell Mol Life Sci (2010) 1.56
Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology (2011) 1.55
The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation. Hum Brain Mapp (2009) 1.55
Magnetic resonance imaging of the Amine-Proton EXchange (APEX) dependent contrast. Neuroimage (2011) 1.54
Procoagulants and osteonecrosis. J Rheumatol (2003) 1.54
Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol (2012) 1.52
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest (2015) 1.52
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature (2016) 1.52
Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med (2009) 1.52
Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci (2011) 1.52
Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner. Crit Care Med (2002) 1.52
Modern analytical techniques in metabolomics analysis. Analyst (2011) 1.52
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem (2007) 1.52
The physiologic effects of caloric restriction are reflected in the in vivo adipocyte-enriched proteome of overweight/obese subjects. J Proteome Res (2009) 1.51
Analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks. PLoS One (2010) 1.51
Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics (2008) 1.50
Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock (2006) 1.50
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50
Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies. Circulation (2010) 1.49
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. J Leukoc Biol (2004) 1.49
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48
Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Ann Surg (2007) 1.48
Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism (2003) 1.47
Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis. Anal Chem (2012) 1.46
The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies. PLoS One (2009) 1.46
Retracted Triple reassortant swine influenza A (H3N2) virus in waterfowl. Emerg Infect Dis (2010) 1.46
Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. Am J Respir Crit Care Med (2009) 1.45