Published in Neurobiol Aging on June 15, 2006
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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
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Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence. J Hematol Oncol (2016) 0.76
Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice. Hum Mol Genet (2015) 0.76
Sirtuin to the rescue: SIRT2 extends life span of BubR1 mice. EMBO J (2014) 0.76
BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Elife (2016) 0.75
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet (2004) 6.85
Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol (2003) 3.40
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol (2007) 2.69
BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev Cell (2009) 2.69
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell (2009) 2.58
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature (2002) 2.50
The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature (2005) 2.33
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell (2008) 2.25
Whole chromosome instability and cancer: a complex relationship. Trends Genet (2008) 2.04
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
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Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (2005) 1.47
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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol (2010) 1.38
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol (2011) 1.35
Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke (2007) 1.35
Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS One (2012) 1.25
In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem (2007) 1.19
p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep (2013) 1.19
Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle (2006) 1.17
CREB binding protein is required for both short-term and long-term memory formation. J Neurosci (2010) 1.14
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol (2012) 1.14
Gene targeting methods for studying nuclear transport factors in mice. Methods (2006) 1.14
Aneuploidy in health, disease, and aging. J Cell Biol (2013) 1.13
Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research. Neuroscientist (2007) 1.13
In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Rep (2013) 1.11
Cdc20 is critical for meiosis I and fertility of female mice. PLoS Genet (2010) 1.11
Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PLoS One (2009) 1.10
Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin. J Am Soc Nephrol (2011) 1.09
Activation of programmed cell death markers in ventral horn motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in a transgenic mouse model. Brain Res (2004) 1.08
Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol (2011) 1.07
Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques. Biochemistry (2004) 1.07
Pharmacokinetic analysis of the blood-brain barrier transport of 125I-amyloid beta protein 40 in wild-type and Alzheimer's disease transgenic mice (APP,PS1) and its implications for amyloid plaque formation. J Pharmacol Exp Ther (2005) 0.99
Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet (2012) 0.96
Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle (2011) 0.94
Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Biochemistry (2009) 0.93
Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: initial results. Magn Reson Imaging (2012) 0.93
CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle (2009) 0.92
Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle (2010) 0.92
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice. Brain Res (2005) 0.92
Comparison of amyloid plaque contrast generated by T2-weighted, T2*-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease. Magn Reson Med (2009) 0.92
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest (2016) 0.91
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A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain. PLoS One (2011) 0.89
Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy. Pharm Res (2008) 0.87
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The yin and yang of the Cdkn2a locus in senescence and aging. Cell Cycle (2008) 0.85
Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice. Circulation (2008) 0.84
A mouse model of familial oligoasthenoteratozoospermia. Hum Reprod (2005) 0.84
Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein. Nanomedicine (2011) 0.84
MR microimaging of amyloid plaques in Alzheimer's disease transgenic mice. Eur J Nucl Med Mol Imaging (2008) 0.83
The role of mitotic checkpoint in maintaining genomic stability. Curr Top Dev Biol (2003) 0.83
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles. J Neuropathol Exp Neurol (2011) 0.83
Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery. Mol Pharm (2012) 0.82
Reprogramming to pluripotency can conceal somatic cell chromosomal instability. PLoS Genet (2012) 0.82
Magnetic resonance imaging of amyloid plaques in transgenic mouse models of Alzheimer's disease. Curr Med Imaging Rev (2011) 0.81
Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice. Neurochem Res (2008) 0.81
Transgenesis in mouse embryonic stem cells. Methods Mol Biol (2011) 0.81
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest (2016) 0.80
Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression. Semin Cell Dev Biol (2011) 0.79
Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid beta40. J Pharmacol Exp Ther (2006) 0.79
Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice. J Pharmacol Exp Ther (2007) 0.79
Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature. Mol Pharm (2013) 0.78
Sgo1 as a "guardian spirit" for preventing colon tumorigenesis. Cell Cycle (2012) 0.76
Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it? Longev Healthspan (2013) 0.75