Published in Nature on October 17, 2002
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A (2007) 4.06
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell (2008) 3.84
Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci U S A (2009) 2.81
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J (2003) 2.61
GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol (2005) 2.55
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem (2008) 2.15
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J (2007) 2.07
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics (2010) 1.92
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
Selective coactivator interactions in gene activation by SREBP-1a and -1c. Mol Cell Biol (2004) 1.75
Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology (2011) 1.74
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J (2007) 1.67
Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification. J Neurosci (2010) 1.65
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Learn Mem (2011) 1.59
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. EMBO J (2010) 1.55
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A (2011) 1.54
Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J (2003) 1.53
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. J Clin Invest (2010) 1.52
Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J (2003) 1.48
Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48
Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol Cell Biol (2006) 1.38
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J (2006) 1.37
Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle (2008) 1.28
Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Genes Dev (2005) 1.28
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol (2009) 1.27
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem (2009) 1.16
Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem (2011) 1.16
Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb. Nucleic Acids Res (2011) 1.13
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood (2010) 1.11
Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci U S A (2010) 1.09
Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc (2013) 0.97
Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. J Clin Invest (2010) 0.96
Myb proteins: angels and demons in normal and transformed cells. Front Biosci (Landmark Ed) (2011) 0.96
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood (2008) 0.95
Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy. Genes Cancer (2015) 0.95
Is histone acetylation the most important physiological function for CBP and p300? Aging (Albany NY) (2012) 0.95
CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription. Mol Brain (2009) 0.95
HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP. J Mol Biol (2011) 0.94
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab (2011) 0.92
A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Res (2010) 0.90
Post-translational modifications of Runx1 regulate its activity in the cell. Blood Cells Mol Dis (2009) 0.90
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Front Oncol (2015) 0.89
Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway. Blood Cells Mol Dis (2011) 0.88
Critical role for a single leucine residue in leukemia induction by E2A-PBX1. Mol Cell Biol (2006) 0.86
Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression. PLoS One (2013) 0.86
Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia. Blood (2009) 0.86
Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression. PLoS One (2013) 0.83
Molecular brake pad hypothesis: pulling off the brakes for emotional memory. Rev Neurosci (2012) 0.82
More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Blood (2006) 0.82
Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions. Leuk Res (2010) 0.81
Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity. J Biol Chem (2011) 0.80
The Crebbp Acetyltransferase is a Haploinsufficient Tumor Suppressor in B Cell Lymphoma. Cancer Discov (2017) 0.80
The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. Cell Death Dis (2013) 0.79
Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues. Biochemistry (2014) 0.78
Fell Pony syndrome: characterization of developmental hematopoiesis failure and associated gene expression profiles. Clin Vaccine Immunol (2012) 0.78
Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress (2013) 0.77
Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proc Natl Acad Sci U S A (2014) 0.77
Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300. Nucleic Acids Res (2014) 0.77
Regulation of delta-aminolevulinic acid dehydratase by krüppel-like factor 1. PLoS One (2012) 0.77
A cell model for conditional profiling of androgen-receptor-interacting proteins. Int J Endocrinol (2012) 0.75
Pharmacological Activators of the NR4A Nuclear Receptors Enhance LTP in a CREB/CBP-Dependent Manner. Neuropsychopharmacology (2016) 0.75
T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One (2014) 0.75
A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. Nucleic Acids Res (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature (2005) 7.14
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet (2004) 6.85
Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28
Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature (2011) 5.20
NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci (2007) 5.02
CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature (2011) 3.72
Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol (2003) 3.40
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J (2010) 3.25
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol (2007) 2.69
BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev Cell (2009) 2.69
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell (2009) 2.58
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood (2009) 2.39
The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature (2005) 2.33
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell (2008) 2.25
GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci U S A (2008) 2.17
A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell (2012) 2.15
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem (2006) 2.11
Whole chromosome instability and cancer: a complex relationship. Trends Genet (2008) 2.04
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol (2006) 2.00
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics (2010) 1.92
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell (2004) 1.80
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J (2005) 1.68
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J (2007) 1.67
From meiosis to postmeiotic events: the secrets of histone disappearance. FEBS J (2009) 1.65
Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J (2012) 1.64
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J Cell Biol (2010) 1.60
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. EMBO J (2010) 1.55
Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol (2006) 1.48
Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. Neurobiol Aging (2006) 1.40
Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood (2008) 1.39
Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res (2009) 1.39
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J (2002) 1.38
Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol (2010) 1.38
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol (2011) 1.35
Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis (2005) 1.35
Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke (2007) 1.35
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol (2009) 1.27
Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B. Genes Dev (2013) 1.24
Genomic binding of Pol III transcription machinery and relationship with TFIIS transcription factor distribution in mouse embryonic stem cells. Nucleic Acids Res (2011) 1.23
Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma. Mol Cancer Res (2009) 1.22
Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Blood (2006) 1.22
Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood (2005) 1.21
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood (2006) 1.21
USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. J Biol Chem (2010) 1.20
Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Oncogene (2002) 1.19
p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep (2013) 1.19
Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle (2006) 1.17
Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learn Mem (2011) 1.16
NIX induces mitochondrial autophagy in reticulocytes. Autophagy (2008) 1.16
Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. Chromosome Res (2009) 1.16
Gene targeting methods for studying nuclear transport factors in mice. Methods (2006) 1.14
CREB binding protein is required for both short-term and long-term memory formation. J Neurosci (2010) 1.14
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol (2012) 1.14
Aneuploidy in health, disease, and aging. J Cell Biol (2013) 1.13
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood (2004) 1.12
In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Rep (2013) 1.11
Cdc20 is critical for meiosis I and fertility of female mice. PLoS Genet (2010) 1.11
Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle (2006) 1.10
Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin. J Am Soc Nephrol (2011) 1.09
Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells (2006) 1.07
Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol (2011) 1.07
The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood (2002) 1.07
Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets. Exp Hematol (2008) 1.06
Mitophagy in mammalian cells: the reticulocyte model. Methods Enzymol (2009) 1.06
BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood (2002) 1.04
Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behav Neurosci (2006) 1.02
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nat Med (2013) 1.02
Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice. J Virol (2011) 0.99
Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med (2002) 0.98
Contemporary seasonal influenza A (H1N1) virus infection primes for a more robust response to split inactivated pandemic influenza A (H1N1) Virus vaccination in ferrets. Clin Vaccine Immunol (2010) 0.98
Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet (2012) 0.96
Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res (2013) 0.95
Is histone acetylation the most important physiological function for CBP and p300? Aging (Albany NY) (2012) 0.95
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways. Cell Cycle (2011) 0.95
Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle (2011) 0.94
CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle (2009) 0.92
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab (2011) 0.92
Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle (2010) 0.92
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest (2016) 0.91