Published in Dev Cell on January 01, 2009
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer (2010) 3.95
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore. Nat Rev Mol Cell Biol (2013) 3.01
Structure of the mitotic checkpoint complex. Nature (2012) 2.72
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol (2010) 2.07
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell (2014) 2.03
BUB1 and BUBR1: multifaceted kinases of the cell cycle. Trends Biochem Sci (2010) 1.99
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
BubR1- and Polo-coated DNA tethers facilitate poleward segregation of acentric chromatids. Cell (2010) 1.83
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci U S A (2010) 1.72
Bub1 regulates chromosome segregation in a kinetochore-independent manner. J Cell Biol (2009) 1.72
Signalling dynamics in the spindle checkpoint response. Nat Rev Mol Cell Biol (2014) 1.71
Spindle assembly checkpoint: the third decade. Philos Trans R Soc Lond B Biol Sci (2011) 1.68
Panta rhei: the APC/C at steady state. J Cell Biol (2013) 1.62
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J Cell Biol (2010) 1.60
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process. Proc Natl Acad Sci U S A (2011) 1.55
Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. J Cell Sci (2011) 1.49
The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell (2012) 1.47
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol (2012) 1.41
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. Chromosoma (2013) 1.39
Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol (2010) 1.38
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol (2011) 1.35
Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint. Mol Cell Biol (2011) 1.29
Mutual regulation between the spindle checkpoint and APC/C. Semin Cell Dev Biol (2011) 1.29
BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. Dev Cell (2014) 1.28
Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Cancer Res (2010) 1.26
Separating the spindle, checkpoint, and timer functions of BubR1. J Cell Biol (2009) 1.25
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators. Dev Cell (2015) 1.23
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell (2013) 1.21
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci (2010) 1.18
BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex. J Biol Chem (2011) 1.17
Structural insights into anaphase-promoting complex function and mechanism. Philos Trans R Soc Lond B Biol Sci (2011) 1.17
Cdc20 is critical for meiosis I and fertility of female mice. PLoS Genet (2010) 1.11
A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint. Elife (2015) 1.10
Kinase signaling in the spindle checkpoint. J Biol Chem (2009) 1.09
Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. J Biol Chem (2010) 1.08
Bub3p facilitates spindle checkpoint silencing in fission yeast. Mol Biol Cell (2009) 1.07
Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells. Cancer Discov (2012) 1.07
Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol (2011) 1.07
Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site. Structure (2011) 1.04
Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1. EMBO J (2011) 1.01
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta (2014) 1.00
Overcoming inhibition in the spindle checkpoint. Genes Dev (2009) 0.99
CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint. J Cell Biol (2012) 0.98
Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms. Genetics (2014) 0.97
Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling. Proc Natl Acad Sci U S A (2014) 0.96
The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis. J Biol Chem (2014) 0.96
Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature (2016) 0.96
Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. PLoS One (2011) 0.95
Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint. Nat Commun (2015) 0.93
Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism. Mol Biol Cell (2010) 0.93
CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle (2009) 0.92
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest (2016) 0.91
Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation. EMBO J (2013) 0.91
KNL1: bringing order to the kinetochore. Chromosoma (2013) 0.91
Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle (2011) 0.88
Sumoylated BubR1 plays an important role in chromosome segregation and mitotic timing. Cell Cycle (2012) 0.88
Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nat Commun (2015) 0.87
Modulation of cell cycle control during oocyte-to-embryo transitions. EMBO J (2013) 0.87
Time-lapse imaging of mitosis after siRNA transfection. J Vis Exp (2010) 0.86
BubR1 is modified by sumoylation during mitotic progression. J Biol Chem (2011) 0.84
Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation. J Cell Biol (2013) 0.83
Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line. Open Biol (2014) 0.83
Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex. Proc Natl Acad Sci U S A (2016) 0.83
Reprogramming to pluripotency can conceal somatic cell chromosomal instability. PLoS Genet (2012) 0.82
TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres. Cell Cycle (2014) 0.82
Acm1 contributes to nuclear positioning by inhibiting Cdh1-substrate interactions. Cell Cycle (2012) 0.80
Relaying the checkpoint signal from kinetochore to APC/C. Dev Cell (2009) 0.78
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nat Commun (2016) 0.78
Active transport can greatly enhance Cdc20:Mad2 formation. Int J Mol Sci (2014) 0.77
Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1. OMICS (2015) 0.76
Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint. Cells (2015) 0.75
Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells. J Biol Chem (2016) 0.75
Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer. Clin Cancer Res (2014) 0.75
Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1. PLoS One (2015) 0.75
BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Elife (2016) 0.75
Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation. Nat Commun (2016) 0.75
Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control. Comput Struct Biotechnol J (2015) 0.75
A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1. Biol Open (2016) 0.75
The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Mol Sci (2016) 0.75
Playing polo during mitosis: PLK1 takes the lead. Oncogene (2017) 0.75
The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol (2003) 9.27
On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer (2005) 7.53
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet (2004) 6.85
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol (2001) 6.80
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell (2001) 5.82
Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol (1999) 5.62
Timing and checkpoints in the regulation of mitotic progression. Dev Cell (2004) 5.41
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature (2007) 4.31
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A (2004) 3.69
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol Biol Cell (2002) 3.65
MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p. J Cell Biol (2000) 3.31
The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat Cell Biol (2004) 3.27
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol (2002) 2.97
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol (1999) 2.82
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol (2007) 2.69
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell (2003) 2.47
The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature (2005) 2.33
Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint. Genes Dev (2007) 2.32
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev (2006) 2.16
Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol (2005) 2.11
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. PLoS One (2007) 2.08
Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner. Mol Cell Biol (2002) 2.07
Whole chromosome instability and cancer: a complex relationship. Trends Genet (2008) 2.04
Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J Cell Sci (1992) 1.97
The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem (2001) 1.84
Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1. Exp Cell Res (2006) 1.82
Flies without a spindle checkpoint. Nat Cell Biol (2007) 1.80
Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model. J Cell Biol (2006) 1.70
The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C). J Biol Chem (2008) 1.61
The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol (2005) 1.47
The mitotic checkpoint gene BubR1 has two distinct functions in mitosis. Exp Cell Res (2005) 1.17
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet (2004) 6.85
Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol (2003) 3.40
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol (2007) 2.69
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell (2009) 2.58
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature (2002) 2.50
The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature (2005) 2.33
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell (2008) 2.25
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol (2006) 2.24
Whole chromosome instability and cancer: a complex relationship. Trends Genet (2008) 2.04
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.98
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem (2008) 1.93
Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci (2007) 1.92
Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J Cell Biol (2010) 1.60
Total disc replacement in the lumbar spine: a systematic review of the literature. Eur Spine J (2006) 1.40
Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. Neurobiol Aging (2006) 1.40
Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res (2009) 1.39
Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol (2010) 1.38
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol (2011) 1.35
Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke (2007) 1.35
p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep (2013) 1.19
Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle (2006) 1.17
Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol (2010) 1.17
The mitotic checkpoint gene BubR1 has two distinct functions in mitosis. Exp Cell Res (2005) 1.17
Gene targeting methods for studying nuclear transport factors in mice. Methods (2006) 1.14
Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol (2012) 1.14
CREB binding protein is required for both short-term and long-term memory formation. J Neurosci (2010) 1.14
Aneuploidy in health, disease, and aging. J Cell Biol (2013) 1.13
In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Rep (2013) 1.11
Cdc20 is critical for meiosis I and fertility of female mice. PLoS Genet (2010) 1.11
Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin. J Am Soc Nephrol (2011) 1.09
Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol (2011) 1.07
Function and structure of lipid storage droplet protein 1 studied in lipoprotein complexes. Arch Biochem Biophys (2008) 1.01
Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet (2012) 0.96
Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle (2011) 0.94
CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle (2009) 0.92
Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle (2010) 0.92
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest (2016) 0.91
Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma. Hepatology (2015) 0.90
Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation. Cell Microbiol (2013) 0.90
Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G. Apoptosis (2009) 0.90
Effect of ultrasound on herpes simplex virus infection in cell culture. Virol J (2011) 0.86
Purification and characterization of recombinant lipid storage protein-2 from Drosophila melanogaster. Protein Pept Lett (2008) 0.85
The yin and yang of the Cdkn2a locus in senescence and aging. Cell Cycle (2008) 0.85
Sequence of a fusogenic herpes simplex virus, RH2, for oncolytic virotherapy. J Gen Virol (2012) 0.85
A mouse model of familial oligoasthenoteratozoospermia. Hum Reprod (2005) 0.84
Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice. Circulation (2008) 0.84
The role of mitotic checkpoint in maintaining genomic stability. Curr Top Dev Biol (2003) 0.83
Repeated bacteraemia caused by Streptococcus mutans in a patient with Sjogren's syndrome. J Med Microbiol (2007) 0.83
Reprogramming to pluripotency can conceal somatic cell chromosomal instability. PLoS Genet (2012) 0.82
Transgenesis in mouse embryonic stem cells. Methods Mol Biol (2011) 0.81
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA. Int J Oncol (2013) 0.80
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest (2016) 0.80
Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression. Semin Cell Dev Biol (2011) 0.79
Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. Self Nonself (2011) 0.78
Sgo1 as a "guardian spirit" for preventing colon tumorigenesis. Cell Cycle (2012) 0.76
Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it? Longev Healthspan (2013) 0.75
A potential addition to continuing professional development points. Clin Teach (2011) 0.75
Furosemide challenge in patients with heart failure and adverse reactions to sulfa-containing diuretics. Ann Intern Med (2003) 0.75