Published in Genetics on June 18, 2006
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
A landscape of driver mutations in melanoma. Cell (2012) 12.61
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Clonal evolution in cancer. Nature (2012) 11.07
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature (2011) 9.71
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science (2015) 3.29
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma. Nat Commun (2014) 3.12
Variation in the mutation rate across mammalian genomes. Nat Rev Genet (2011) 3.09
Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature (2016) 3.05
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet (2014) 2.72
Identifying cancer driver genes in tumor genome sequencing studies. Bioinformatics (2010) 2.52
Emerging patterns of somatic mutations in cancer. Nat Rev Genet (2013) 2.50
Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics (2008) 1.95
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood (2013) 1.84
Simultaneous identification of multiple driver pathways in cancer. PLoS Comput Biol (2013) 1.71
Expanding the computational toolbox for mining cancer genomes. Nat Rev Genet (2014) 1.60
Cancer genome-sequencing study design. Nat Rev Genet (2013) 1.55
The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol (2013) 1.54
Defining the blueprint of the cancer genome. Carcinogenesis (2008) 1.49
PathScan: a tool for discerning mutational significance in groups of putative cancer genes. Bioinformatics (2011) 1.46
Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle (2009) 1.44
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39
Analytical methods for inferring functional effects of single base pair substitutions in human cancers. Hum Genet (2009) 1.39
Cancer evolution: mathematical models and computational inference. Syst Biol (2014) 1.36
Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat Genet (2014) 1.33
Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine. Genome Med (2014) 1.31
DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer. Genome Biol (2012) 1.21
Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project. Gut (2011) 1.20
New cast for a new era: preclinical cancer drug development revisited. J Clin Invest (2013) 1.11
NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes. Database (Oxford) (2014) 1.10
Translating cancer 'omics' to improved outcomes. Genome Res (2012) 1.07
MoKCa database--mutations of kinases in cancer. Nucleic Acids Res (2008) 1.06
Inactivating CUX1 mutations promote tumorigenesis. Nat Genet (2013) 1.06
A framework for evolutionary systems biology. BMC Syst Biol (2009) 1.05
A novel missense-mutation-related feature extraction scheme for 'driver' mutation identification. Bioinformatics (2012) 1.04
A syngeneic variance library for functional annotation of human variation: application to BRCA2. Cancer Res (2008) 1.02
Germline fitness-based scoring of cancer mutations. Genetics (2011) 1.02
Processed pseudogenes acquired somatically during cancer development. Nat Commun (2014) 1.00
Statistical method on nonrandom clustering with application to somatic mutations in cancer. BMC Bioinformatics (2010) 0.97
Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis. Proc Natl Acad Sci U S A (2015) 0.96
Prioritization of pathogenic mutations in the protein kinase superfamily. BMC Genomics (2012) 0.95
Cross-cancer profiling of molecular alterations within the human autophagy interaction network. Autophagy (2015) 0.94
DrGaP: a powerful tool for identifying driver genes and pathways in cancer sequencing studies. Am J Hum Genet (2013) 0.90
Structural and functional impact of cancer-related missense somatic mutations. J Mol Biol (2011) 0.89
Genetic signature for human risk assessment: lessons from trichloroethylene. Environ Mol Mutagen (2009) 0.84
Human variation databases. Database (Oxford) (2010) 0.84
Structure-Based Analysis Reveals Cancer Missense Mutations Target Protein Interaction Interfaces. PLoS One (2016) 0.80
A quantum leap in our knowledge of breast cancer mutations. Breast Cancer Res (2006) 0.80
wKinMut: an integrated tool for the analysis and interpretation of mutations in human protein kinases. BMC Bioinformatics (2013) 0.79
The continuing search for cancer-causing somatic mutations. Breast Cancer Res (2007) 0.78
Decreased Mitochondrial Mutagenesis during Transformation of Human Breast Stem Cells into Tumorigenic Cells. Cancer Res (2016) 0.78
Making connections: using networks to stratify human tumors. Nat Methods (2013) 0.77
Detection of Ultra-Rare Mitochondrial Mutations in Breast Stem Cells by Duplex Sequencing. PLoS One (2015) 0.77
Identification and analysis of driver missense mutations using rotation forest with feature selection. Biomed Res Int (2014) 0.75
Identification and analysis of mutational hotspots in oncogenes and tumour suppressors. Oncotarget (2017) 0.75
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
A codon-based model of nucleotide substitution for protein-coding DNA sequences. Mol Biol Evol (1994) 19.91
Ensembl 2005. Nucleic Acids Res (2005) 15.13
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet (2005) 6.70
Spontaneous point mutations that occur more often when advantageous than when neutral. Genetics (1990) 4.89
The UMD-p53 database: new mutations and analysis tools. Hum Mutat (2003) 2.89
Likelihood models of somatic mutation and codon substitution in cancer genes. Genetics (2003) 2.46
RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database. BMC Genet (2005) 2.08
A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data. Math Biosci (2003) 1.81
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
The cancer genome. Nature (2009) 23.13
Signatures of mutational processes in human cancer. Nature (2013) 21.63
International network of cancer genome projects. Nature (2010) 20.35
A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72
Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91
Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature (2009) 13.45
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
The life history of 21 breast cancers. Cell (2012) 10.59
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet (2002) 9.71
Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med (2008) 9.64
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res (2009) 9.59
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet (2006) 9.17
Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet (2002) 8.89
BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res (2002) 8.55
Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature (2004) 8.35
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med (2007) 8.18
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet (2006) 7.72
Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res (2005) 7.66
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc Natl Acad Sci U S A (2008) 7.22
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res (2006) 6.91