Published in Nucleic Acids Res on November 11, 2009
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Ensembl BioMarts: a hub for data retrieval across taxonomic space. Database (Oxford) (2011) 6.04
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PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol (2012) 4.77
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Predicting selective drug targets in cancer through metabolic networks. Mol Syst Biol (2011) 3.65
The next-generation sequencing revolution and its impact on genomics. Cell (2013) 3.35
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26
The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet (2013) 2.89
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Temporal dissection of tumorigenesis in primary cancers. Cancer Discov (2011) 2.40
Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. Cancer Discov (2012) 2.27
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell (2011) 2.17
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell (2011) 2.13
Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. Nat Genet (2014) 2.11
IntOGen-mutations identifies cancer drivers across tumor types. Nat Methods (2013) 2.10
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood (2014) 1.92
Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. Mol Syst Biol (2013) 1.78
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol (2010) 1.73
Clinical characteristics and course of 63 patients with BRAF mutant lung cancers. J Thorac Oncol (2014) 1.53
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Mutations in CEP57 cause mosaic variegated aneuploidy syndrome. Nat Genet (2011) 1.46
Biomarkers of response to Akt inhibitor MK-2206 in breast cancer. Clin Cancer Res (2012) 1.44
CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge. Nucleic Acids Res (2010) 1.44
Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. Cancer Res (2010) 1.41
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet (2011) 1.41
Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function. Nucleic Acids Res (2013) 1.38
Protocol matters: which methylome are you actually studying? Epigenomics (2010) 1.37
Reassessing target antigens for adoptive T-cell therapy. Nat Biotechnol (2013) 1.34
Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness. Oncogene (2011) 1.33
Genome Maps, a new generation genome browser. Nucleic Acids Res (2013) 1.33
MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing. Genome Biol (2014) 1.32
Next-generation sequencing to guide cancer therapy. Genome Med (2015) 1.31
Induction of human epithelial stem/progenitor expansion by FOXM1. Cancer Res (2010) 1.27
Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PLoS One (2011) 1.27
Integrative cancer genomics (IntOGen) in Biomart. Database (Oxford) (2011) 1.26
Network enrichment analysis: extension of gene-set enrichment analysis to gene networks. BMC Bioinformatics (2012) 1.24
dbDEMC: a database of differentially expressed miRNAs in human cancers. BMC Genomics (2010) 1.20
Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. Leukemia (2011) 1.18
Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. Genome Res (2013) 1.15
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat Genet (2016) 1.15
Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing. PLoS One (2014) 1.14
Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide. Br J Cancer (2011) 1.13
A framework for organizing cancer-related variations from existing databases, publications and NGS data using a High-performance Integrated Virtual Environment (HIVE). Database (Oxford) (2014) 1.12
A bioinformatics approach for precision medicine off-label drug drug selection among triple negative breast cancer patients. J Am Med Inform Assoc (2016) 1.11
Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells. Genome Biol (2015) 1.11
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PLoS One (2010) 1.10
Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines. PLoS One (2011) 1.10
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. Neuro Oncol (2011) 1.10
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proc Natl Acad Sci U S A (2011) 1.09
Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics. Genome Biol (2015) 1.07
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife (2014) 1.06
Identification of nine genomic regions of amplification in urothelial carcinoma, correlation with stage, and potential prognostic and therapeutic value. PLoS One (2013) 1.05
Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. Cancer Lett (2011) 1.04
Shimmer: detection of genetic alterations in tumors using next-generation sequence data. Bioinformatics (2013) 1.02
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. Nature (2015) 1.01
Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges. Cancers (Basel) (2015) 1.01
A self-validating quantitative mass spectrometry method for assessing the accuracy of high-content phosphoproteomic experiments. Mol Cell Proteomics (2010) 1.01
Regulation of ROCK activity in cancer. J Histochem Cytochem (2012) 1.01
Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics (2012) 0.99
Diverse modes of genomic alteration in hepatocellular carcinoma. Genome Biol (2014) 0.99
Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center. Oncologist (2015) 0.97
Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing. J Clin Oncol (2015) 0.96
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. Biochem J (2012) 0.95
Next-generation sequencing in breast cancer: first take home messages. Curr Opin Oncol (2012) 0.95
Liverome: a curated database of liver cancer-related gene signatures with self-contained context information. BMC Genomics (2011) 0.95
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database (Oxford) (2016) 0.95
An analysis of substitution, deletion and insertion mutations in cancer genes. Nucleic Acids Res (2012) 0.95
myKaryoView: a light-weight client for visualization of genomic data. PLoS One (2011) 0.94
Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients. Br J Cancer (2015) 0.94
COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma. BMC Clin Pathol (2010) 0.94
Cancer3D: understanding cancer mutations through protein structures. Nucleic Acids Res (2014) 0.93
Integrated metabolome and transcriptome analysis of the NCI60 dataset. BMC Bioinformatics (2011) 0.93
The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction. J Biol Chem (2010) 0.93
Multiple mechanisms of MYCN dysregulation in Wilms tumour. Oncotarget (2015) 0.91
Different phenotypic consequences of simultaneous versus stepwise Apc loss. Oncogene (2011) 0.91
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol (2014) 0.90
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest (2015) 0.90
Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas. Genome Biol (2015) 0.90
Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer. Cancer Metastasis Rev (2010) 0.90
The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo. Clin Cancer Res (2013) 0.89
Immune status, strain background, and anatomic site of inoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas. PLoS One (2014) 0.89
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
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Circos: an information aesthetic for comparative genomics. Genome Res (2009) 40.02
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet (2008) 16.09
Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat (2000) 13.25
BioMart Central Portal--unified access to biological data. Nucleic Acids Res (2009) 9.06
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
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Signatures of mutational processes in human cancer. Nature (2013) 21.63
International network of cancer genome projects. Nature (2010) 20.35
A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell (2011) 16.72
Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature (2009) 13.45
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
The life history of 21 breast cancers. Cell (2012) 10.59
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet (2002) 9.71