Published in Diabetes on July 01, 2006
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Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice. Endocrinology (2011) 0.84
Glyburide reduces bacterial dissemination in a mouse model of melioidosis. PLoS Negl Trop Dis (2013) 0.84
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Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain. Cell Rep (2016) 0.83
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Mitochondrial ROS Metabolism: 10 Years Later. Biochemistry (Mosc) (2015) 0.81
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Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo. Diabetes (2015) 0.81
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FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes. J Biol Chem (2016) 0.78
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Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. Antioxid Redox Signal (2016) 0.76
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Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice. Dis Model Mech (2014) 0.76
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Comparison of Neurological Function in Males and Females from Two Substrains of C57BL/6 Mice. Toxics (2014) 0.76
A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice. Diabetes (2016) 0.76
The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria. J Biol Chem (2016) 0.76
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TEMPOL increases NAD(+) and improves redox imbalance in obese mice. Redox Biol (2016) 0.75
Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism. Biol Open (2016) 0.75
High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains. J Endocrinol (2017) 0.75
Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender. Dis Model Mech (2015) 0.75
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Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer. Bio Protoc (2016) 0.75
A genetically encoded tool for manipulation of NADP(+)/NADPH in living cells. Nat Chem Biol (2017) 0.75
C57BL/6 substrains exhibit different responses to acute carbon tetrachloride exposure: Implications for work involving transgenic mice. Gene Expr (2017) 0.75
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med (2004) 8.62
Crystal structure of the potassium channel KirBac1.1 in the closed state. Science (2003) 7.46
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med (2006) 7.31
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35
Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. Diabetes (2005) 2.95
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet (2007) 2.91
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metab (2006) 2.21
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet (2003) 2.02
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes. Hum Mol Genet (2006) 1.83
A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome (2004) 1.82
Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit. EMBO J (2005) 1.79
A gene-driven approach to the identification of ENU mutants in the mouse. Nat Genet (2002) 1.76
Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects. Am J Hum Genet (2007) 1.73
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. Proc Natl Acad Sci U S A (2004) 1.72
3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. EMBO J (2005) 1.66
ENU mutagenesis, a way forward to understand gene function. Annu Rev Genomics Hum Genet (2008) 1.59
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet. J Physiol (2010) 1.55
Relapsing diabetes can result from moderately activating mutations in KCNJ11. Hum Mol Genet (2005) 1.52
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest (2008) 1.50
Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clin Sci (Lond) (2009) 1.47
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Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis. EMBO J (2007) 1.41
PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations. Biochemistry (2009) 1.40
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome. EMBO Rep (2005) 1.32
Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science (2010) 1.31
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Studies of the ATPase activity of the ABC protein SUR1. FEBS J (2007) 1.28
Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metab (2009) 1.26
Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A (2013) 1.24
Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides. Hum Mol Genet (2002) 1.24
Novel phenotypes identified by plasma biochemical screening in the mouse. Mamm Genome (2002) 1.22
Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11. Nat Clin Pract Neurol (2007) 1.22
Identification of residues contributing to the ATP binding site of Kir6.2. EMBO J (2003) 1.22
The ligand-sensitive gate of a potassium channel lies close to the selectivity filter. EMBO Rep (2003) 1.20
Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab (2013) 1.18
Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants. Biophys J (2003) 1.17
Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP. Hum Mol Genet (2005) 1.17
Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome. Hum Mol Genet (2007) 1.14
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat Cell Biol (2007) 1.12
Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger. J Neurosci (2003) 1.12
Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. Proc Natl Acad Sci U S A (2007) 1.11
Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes. Pflugers Arch (2006) 1.09
Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels. J Cell Sci (2006) 1.08
Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-Type potassium channels. J Neurosci (2002) 1.08
Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages. Lab Anim (2010) 1.07
Potassium channel regulation. EMBO Rep (2003) 1.07
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease. Am J Physiol Renal Physiol (2009) 1.06
Retracted Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons. J Neurosci (2007) 1.06
Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS). Epilepsia (2004) 1.03
Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. J Neurosci (2007) 1.03
Modeling K(ATP) channel gating and its regulation. Prog Biophys Mol Biol (2008) 1.03
On the evolutionary origins of obesity: a new hypothesis. Endocrinology (2014) 1.02
FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. PLoS One (2011) 1.02
A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes (2006) 1.01
Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase. Methods Enzymol (2009) 1.00
Focus on Kir6.2: a key component of the ATP-sensitive potassium channel. J Mol Cell Cardiol (2005) 1.00
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One (2012) 0.99
ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2003) 0.99
Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions. EMBO J (2005) 0.98
Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy. Diabetes (2006) 0.98
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ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells. Diabetes (2006) 0.98
A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes (2004) 0.97
A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes. EMBO Rep (2008) 0.97
Asymmetric switching in a homodimeric ABC transporter: a simulation study. PLoS Comput Biol (2010) 0.97
ENU mutagenesis in the mouse: application to human genetic disease. Brief Funct Genomic Proteomic (2002) 0.97
How ATP inhibits the open K(ATP) channel. J Gen Physiol (2008) 0.97
Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism. EMBO Mol Med (2009) 0.97
Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects. Diabetes (2006) 0.96
Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes. Diabetes (2013) 0.96
Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study. Biochemistry (2007) 0.95
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes (2008) 0.95
Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels. J Physiol (2005) 0.95
Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis. Am J Pathol (2013) 0.95
A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation. J Bone Miner Res (2012) 0.94
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes (2002) 0.93
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