Published in Acta Crystallogr Sect F Struct Biol Cryst Commun on June 10, 2006
In vitro selection of BNA (LNA) aptamers. Artif DNA PNA XNA (2013) 0.81
Crystallization and X-ray diffraction analysis of an 'all-locked' nucleic acid duplex derived from a tRNA(Ser) microhelix. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.80
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (1990) 35.96
In vitro selection of RNA molecules that bind specific ligands. Nature (1990) 30.19
Adaptive recognition by nucleic acid aptamers. Science (2000) 5.33
Aptamers: an emerging class of therapeutics. Annu Rev Med (2005) 4.15
LNA: a versatile tool for therapeutics and genomics. Trends Biotechnol (2003) 3.90
Tumor targeting by an aptamer. J Nucl Med (2006) 2.68
Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res (2002) 2.58
Analytical applications of aptamers. Biosens Bioelectron (2004) 1.93
Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids. J Am Chem Soc (2002) 1.88
Tenascin-C aptamers are generated using tumor cells and purified protein. J Biol Chem (2001) 1.81
Developing aptamers into therapeutics. J Clin Invest (2000) 1.68
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function. Nucleic Acids Res (2004) 1.54
Crystal structure of acceptor stem of tRNA(Ala) from Escherichia coli shows unique G.U wobble base pair at 1.16 A resolution. RNA (1999) 1.50
Meet the tenascins: multifunctional and mysterious. J Biol Chem (2005) 1.50
Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology. Oligonucleotides (2004) 1.37
NMR studies of fully modified locked nucleic acid (LNA) hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid. Bioconjug Chem (2004) 1.27
LNA-antisense rivals siRNA for gene silencing. Curr Opin Drug Discov Devel (2004) 1.10
Nucleic acid aptamers as tools and drugs: recent developments. Chembiochem (2003) 1.05
Crystal structure of an RNA dodecamer containing the Escherichia coli Shine-Dalgarno sequence. J Mol Biol (1995) 1.04
Regulatory aspects of drug approval for macular degeneration. Adv Drug Deliv Rev (2005) 0.82
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid. J Am Chem Soc (2005) 0.82
5S Ribosomal RNA Database. Nucleic Acids Res (2002) 5.95
In vivo protein crystallization opens new routes in structural biology. Nat Methods (2012) 2.69
Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res (2002) 2.58
Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions. J Mol Biol (2005) 1.86
Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation (2009) 1.71
Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med (2012) 1.57
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function. Nucleic Acids Res (2004) 1.54
Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res (2003) 1.42
Probing the SELEX process with next-generation sequencing. PLoS One (2011) 1.34
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA (2008) 1.34
A new frontier for molecular medicine: noncoding RNAs. Biochim Biophys Acta (2005) 1.31
Noncoding regulatory RNAs database. Nucleic Acids Res (2003) 1.29
Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy. Nucleic Acids Res (2009) 1.28
Dimerization of the major birch pollen allergen Bet v 1 is important for its in vivo IgE-cross-linking potential in mice. J Immunol (2005) 1.22
Efficient UV detection of protein crystals enabled by fluorescence excitation at wavelengths longer than 300 nm. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.20
5 S rRNA: structure and interactions. Biochem J (2003) 1.20
Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis. FEBS J (2011) 1.19
Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases. Nucleic Acids Res (2010) 1.18
A streamlined protocol for emulsion polymerase chain reaction and subsequent purification. Anal Biochem (2010) 1.15
RNA cleaving '10-23' DNAzymes with enhanced stability and activity. Nucleic Acids Res (2003) 1.14
Comparative study of DNA enzymes and ribozymes against the same full-length messenger RNA of the vanilloid receptor subtype I. J Biol Chem (2001) 1.13
Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy. J Mol Med (Berl) (2008) 1.13
The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle. J Mol Biol (2011) 1.13
Cellular uptake and localization of a Cy3-labeled siRNA specific for the serine/threonine kinase Pim-1. Oligonucleotides (2003) 1.10
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem Biophys Res Commun (2006) 1.09
Sequence requirements in the catalytic core of the "10-23" DNA enzyme. J Biol Chem (2002) 1.08
The first crystal structure of an RNA racemate. Acta Crystallogr D Biol Crystallogr (2006) 1.08
Trypsin revisited: crystallography AT (SUB) atomic resolution and quantum chemistry revealing details of catalysis. J Biol Chem (2003) 1.08
Noncoding RNAs database (ncRNAdb). Nucleic Acids Res (2006) 1.08
Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndrome. Nucleic Acids Res (2011) 1.06
The Nano-tag, a streptavidin-binding peptide for the purification and detection of recombinant proteins. Protein Expr Purif (2004) 1.03
3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses. J Virol (2013) 1.03
Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J Biol Chem (2011) 1.01
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases. Biochem Biophys Res Commun (2006) 1.00
Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol Cell Neurosci (2007) 0.99
A DNA aptamer with high affinity and specificity for therapeutic anthracyclines. Anal Biochem (2007) 0.98
The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities. J Proteome Res (2010) 0.98
Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.97
The 10.8-A structure of Saccharomyces cerevisiae phosphofructokinase determined by cryoelectron microscopy: localization of the putative fructose 6-phosphate binding sites. J Struct Biol (2003) 0.97
Searching sequence space for high-affinity binding peptides using ribosome display. J Mol Biol (2003) 0.97
Crystallographic and X-ray absorption spectroscopic characterization of Helicobacter pylori UreE bound to Ni²⁺ and Zn²⁺ reveals a role for the disordered C-terminal arm in metal trafficking. Biochem J (2012) 0.97
Trypanosoma brucei ATG8: structural insights into autophagic-like mechanisms in protozoa. Autophagy (2009) 0.96
Selection of RNA aptamers to the Alzheimer's disease amyloid peptide. Biochem Biophys Res Commun (2002) 0.95
Gaining target access for deoxyribozymes. J Mol Biol (2004) 0.95
A calibrated diversity assay for nucleic acid libraries using DiStRO--a Diversity Standard of Random Oligonucleotides. Nucleic Acids Res (2009) 0.94
Structure of mistletoe lectin I from Viscum album in complex with the phytohormone zeatin. Biochim Biophys Acta (2008) 0.94
Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue. Am J Pathol (2003) 0.94
Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1. Neurochem Int (2006) 0.94
The structure of a functional unit from the wall of a gastropod hemocyanin offers a possible mechanism for cooperativity. Biochemistry (2003) 0.93
CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. PLoS One (2010) 0.93
RNA interference in pain research. J Neurochem (2006) 0.92
Application of small interfering RNAs modified by unlocked nucleic acid (UNA) to inhibit the heart-pathogenic coxsackievirus B3. FEBS Lett (2010) 0.92
Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro. J Struct Biol (2006) 0.92
The 1.2A crystal structure of an E. coli tRNASer)acceptor stem microhelix reveals two magnesium binding sites. Biochem Biophys Res Commun (2009) 0.90
Crystallographic characterization of CCG repeats. Nucleic Acids Res (2012) 0.90
Semi-automated selection of DNA aptamers using magnetic particle handling. Biotechniques (2007) 0.89
Crystallographic analysis of a thermoactive nitrilase. J Struct Biol (2010) 0.89
X-ray structural studies of the fungal laccase from Cerrena maxima. J Biol Inorg Chem (2006) 0.88
Deletion analysis in the catalytic region of the 10-23 DNA enzyme. FEBS Lett (2005) 0.88
Structure of the functional domain of the major grass-pollen allergen Phlp 5b. Acta Crystallogr D Biol Crystallogr (2002) 0.88
Proteome analysis of snake venom toxins: pharmacological insights. Expert Rev Proteomics (2008) 0.88
Spiegelzymes: sequence specific hydrolysis of L-RNA with mirror image hammerhead ribozymes and DNAzymes. PLoS One (2013) 0.87
Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) -- relation to pharmacological activities. J Proteomics (2009) 0.87
The crystal structure of an 'All Locked' nucleic acid duplex. Nucleic Acids Res (2010) 0.87
Peptide mimics of the Bowman-Birk inhibitor reactive site loop. Biopolymers (2002) 0.87
Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor. Biol Chem (2005) 0.87
The secretory omega-class glutathione transferase OvGST3 from the human pathogenic parasite Onchocerca volvulus. FEBS J (2008) 0.87
Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum. J Biol Chem (2003) 0.86
Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose. FEBS J (2009) 0.86
The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 A resolution. Acta Crystallogr D Biol Crystallogr (2009) 0.86
Single-drop optimization of protein crystallization. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.86
Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs. J Mol Biol (2004) 0.86