Therapeutic targeting of autophagy in disease: biology and pharmacology.

Autophagy and human diseases. Cell Res (2013) 2.17

Development of autophagy inducers in clinical medicine. J Clin Invest (2015) 1.33

Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer. Cancer Biol Ther (2014) 1.04

Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med (2015) 0.99

The importance of autophagy regulation in breast cancer development and treatment. Biomed Res Int (2014) 0.95

MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors. Oncotarget (2014) 0.87

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell Biosci (2015) 0.84

Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy. Front Oncol (2015) 0.83

Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies. Curr Neuropharmacol (2016) 0.83

Autophagy: an emerging therapeutic target in vascular diseases. Br J Pharmacol (2015) 0.82

Proteotoxicity and cardiac dysfunction. Circ Res (2015) 0.81

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proc Natl Acad Sci U S A (2015) 0.80

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia. Oncotarget (2016) 0.80

Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement. BMC Neurosci (2015) 0.79

Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS One (2014) 0.79

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett (2016) 0.78

Long non-coding RNAs act as regulators of cell autophagy in diseases (Review). Oncol Rep (2017) 0.77

Activity of BKM120 and BEZ235 against Lymphoma Cells. Biomed Res Int (2015) 0.77

Autophagy regulation in the development and treatment of breast cancer. Acta Biochim Biophys Sin (Shanghai) (2015) 0.77

Autophagy regulates the survival of cells with chromosomal instability. Oncotarget (2016) 0.76

Effect of beclin 1 expression on the biological behavior and chemotherapy sensitivity of cervical cancer cells. Oncol Lett (2016) 0.75

Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of rapamycin pathway in hepatocellular carcinoma HepG2 cells. Oncol Lett (2016) 0.75

Investigating regulatory signatures of human autophagy related gene 5 (ATG5) through functional in silico analysis. Meta Gene (2016) 0.75

Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner. EMBO Rep (2015) 0.75

ACTP: A webserver for predicting potential targets and relevant pathways of autophagy-modulating compounds. Oncotarget (2016) 0.75

Mechanisms of drug resistance in colon cancer and its therapeutic strategies. World J Gastroenterol (2016) 0.75

Novel autophagy inducers lentztrehaloses A, B and C. J Antibiot (Tokyo) (2015) 0.75

The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells. Cancer Cell Int (2017) 0.75

The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome. eNeuro (2017) 0.75

AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells. Oncotarget (2017) 0.75

Production of Human ATG Proteins for Lipidation Assays. Methods Enzymol (2016) 0.75

Temozolomide induces autophagy in primary and established glioblastoma cells in an EGFR independent manner. Oncol Lett (2017) 0.75

Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells. Cell Death Dis (2017) 0.75

An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAF(V600E) inhibitor-resistant metastatic melanoma cells. Autophagy (2017) 0.75

Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin. Int J Nanomedicine (2017) 0.75

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39

Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62

The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73

Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68

Upstream and downstream of mTOR. Genes Dev (2004) 21.61

Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res (2006) 18.44

Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81

AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

Autophagy: process and function. Genes Dev (2007) 15.21

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74

Autophagy in health and disease: a double-edged sword. Science (2004) 13.69

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73

A protein conjugation system essential for autophagy. Nature (1998) 12.71

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26

Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature (2006) 12.13

mTOR and cancer: insights into a complex relationship. Nat Rev Cancer (2006) 11.86

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29

Autophagy in immunity and inflammation. Nature (2011) 11.16

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science (2004) 10.77

Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70

Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66

A ubiquitin-like system mediates protein lipidation. Nature (2000) 10.61

TOR, a central controller of cell growth. Cell (2000) 10.41

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96

Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84

The roles of intracellular protein-degradation pathways in neurodegeneration. Nature (2006) 9.77

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol (2009) 9.63

Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61

Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell (2006) 9.47

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85

Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med (2007) 8.82

Potential therapeutic applications of autophagy. Nat Rev Drug Discov (2007) 8.56

Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res (2007) 8.44

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol (2007) 8.29

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25

The role of autophagy in cancer development and response to therapy. Nat Rev Cancer (2005) 8.18

Autophagy and metabolism. Science (2010) 8.10

Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65

Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43

Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol (2007) 7.43

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol (1998) 7.41

Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32

Ambra1 regulates autophagy and development of the nervous system. Nature (2007) 6.94

Autophagy as a cell death and tumor suppressor mechanism. Oncogene (2004) 6.92

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88

Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84

Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80

Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69

Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62

Cytoplasmic components in hepatic cell lysosomes. J Cell Biol (1962) 6.57

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56

Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell (2007) 6.39

Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature (2000) 6.34

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics (1999) 6.23

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22

Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17

Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity (2006) 6.17

A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01

Autophagy in mammalian development and differentiation. Nat Cell Biol (2010) 5.99

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy and aging. Cell (2011) 5.96

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85

Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. Bioorg Med Chem (2003) 3.13

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol (2008) 2.56

eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res (2011) 2.10

Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy (2009) 2.09

AACR-FDA-NCI Cancer Biomarkers Collaborative consensus report: advancing the use of biomarkers in cancer drug development. Clin Cancer Res (2010) 2.06

Elongation factor-2 kinase regulates autophagy in human glioblastoma cells. Cancer Res (2006) 1.89

Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells. Cancer Res (2003) 1.71

The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res (2005) 1.57

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Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer. Cancer Res (2002) 1.56

Transcription-dependent degradation of topoisomerase I-DNA covalent complexes. Mol Cell Biol (2003) 1.43

Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy. Cancer Res (2009) 1.42

Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41

Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res (2003) 1.39

MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther (2011) 1.33

Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res (2003) 1.33

Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition. PLoS One (2010) 1.29

Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells. Mol Pharmacol (2007) 1.29

Regulation of the stability of P-glycoprotein by ubiquitination. Mol Pharmacol (2004) 1.19

Involvement of CtBP1 in the transcriptional activation of the MDR1 gene in human multidrug resistant cancer cells. Biochem Pharmacol (2007) 1.14

EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer. Clin Cancer Res (2008) 1.11

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A matter of life or death (or both): understanding autophagy in cancer. Clin Cancer Res (2006) 0.99

Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-Seq data. PLoS One (2012) 0.99

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Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death. PLoS One (2012) 0.91

Targeting autophagic pathways for cancer drug discovery. Chin J Cancer (2012) 0.91

Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells. Cancer Sci (2007) 0.91

Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun (2011) 0.90

Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy (2012) 0.90

Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis. Cancer Res (2012) 0.88

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Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells. Chemotherapy (2008) 0.86

A Phase I/pilot study of sequential doxorubicin/vinorelbine: effects on p53 and microtubule-associated protein 4. Clin Cancer Res (2002) 0.84

Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma. PLoS One (2013) 0.84

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P-glycoprotein mediates resistance to histidine kinase inhibitors. Mol Pharmacol (2004) 0.81

eEF-2 kinase, another meddler in the "yin and yang" of Akt-mediated cell fate? Autophagy (2011) 0.80

Effect of the multidrug resistance protein on the transport of the antiandrogen flutamide. Cancer Res (2003) 0.80

Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53. J Exp Ther Oncol (2002) 0.79

11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity. Bioorg Med Chem (2004) 0.79

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Sustaining the clinical in clinical translational research. Clin Cancer Res (2006) 0.78

NAC1 and HMGB1 enter a partnership for manipulating autophagy. Autophagy (2011) 0.78

Central nervous system progression during systemic response to trastuzumab, humanized anti-HER-2/neu antibody, plus paclitaxel in a woman with refractory metastatic breast cancer. Breast J (2003) 0.78

Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression. BMC Genomics (2008) 0.78

Roles of eEF-2 kinase in cancer. Chin Med J (Engl) (2012) 0.77

Involvement of phosphatidylinositol-3-kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells. Biochem Pharmacol (2002) 0.77

Triticuside A, a dietary flavonoid, inhibits proliferation of human breast cancer cells via inducing apoptosis. Nutr Cancer (2013) 0.76