Published in Mol Cell on July 21, 2006
Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell (2009) 14.51
What recent ribosome structures have revealed about the mechanism of translation. Nature (2009) 4.01
GTP hydrolysis by IF2 guides progression of the ribosome into elongation. Mol Cell (2009) 1.59
Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA. Nucleic Acids Res (2009) 1.52
The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli. PLoS Biol (2011) 1.35
The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. EMBO Rep (2010) 1.24
Preparation and evaluation of acylated tRNAs. Methods (2008) 1.20
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection. Genes Dev (2008) 1.19
Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis. Proc Natl Acad Sci U S A (2011) 1.18
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli. EMBO J (2008) 1.17
Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting. EMBO J (2008) 1.17
Characterization of 16S rRNA mutations that decrease the fidelity of translation initiation. RNA (2007) 1.14
Real-time assembly landscape of bacterial 30S translation initiation complex. Nat Struct Mol Biol (2012) 1.13
Control of translation initiation involves a factor-induced rearrangement of helix 44 of 16S ribosomal RNA. Mol Microbiol (2009) 1.10
A single mammalian mitochondrial translation initiation factor functionally replaces two bacterial factors. Mol Cell (2008) 1.06
Contribution of ribosomal residues to P-site tRNA binding. Nucleic Acids Res (2009) 1.01
Modeling protein association mechanisms and kinetics. Curr Opin Struct Biol (2013) 0.96
Crucial contribution of the multiple copies of the initiator tRNA genes in the fidelity of tRNA(fMet) selection on the ribosomal P-site in Escherichia coli. Nucleic Acids Res (2010) 0.96
The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3mt. Nucleic Acids Res (2007) 0.96
Conformational selection of translation initiation factor 3 signals proper substrate selection. Nat Struct Mol Biol (2013) 0.95
Molecular mechanisms leading to null-protein product from retinoschisin (RS1) signal-sequence mutants in X-linked retinoschisis (XLRS) disease. Hum Mutat (2010) 0.94
Eukaryotic initiator tRNA: finely tuned and ready for action. FEBS Lett (2010) 0.92
Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits. EMBO J (2010) 0.91
Autoregulatory systems controlling translation factor expression: thermostat-like control of translational accuracy. RNA (2010) 0.90
Role of helix 44 of 16S rRNA in the fidelity of translation initiation. RNA (2012) 0.89
Translation initiation factor 3 regulates switching between different modes of ribosomal subunit joining. J Mol Biol (2014) 0.88
Short spacing between the Shine-Dalgarno sequence and P codon destabilizes codon-anticodon pairing in the P site to promote +1 programmed frameshifting. Mol Microbiol (2010) 0.88
Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance. Mol Microbiol (2010) 0.86
The ribosome in action: Tuning of translational efficiency and protein folding. Protein Sci (2016) 0.83
Ribosomal initiation complex-driven changes in the stability and dynamics of initiation factor 2 regulate the fidelity of translation initiation. J Mol Biol (2015) 0.81
Mitochondrial translation initiation machinery: conservation and diversification. Biochimie (2013) 0.80
Initiation with elongator tRNAs. J Bacteriol (2013) 0.80
Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Nucleic Acids Res (2012) 0.80
An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA. Proc Natl Acad Sci U S A (2014) 0.79
Roles of helix H69 of 23S rRNA in translation initiation. Proc Natl Acad Sci U S A (2015) 0.78
Is the cellular initiation of translation an exclusive property of the initiator tRNAs? RNA Biol (2015) 0.78
Intersubunit Bridges of the Bacterial Ribosome. J Mol Biol (2016) 0.77
The emerging role of rectified thermal fluctuations in initiator aa-tRNA- and start codon selection during translation initiation. Biochimie (2015) 0.77
Structural insight into the recognition of amino-acylated initiator tRNA by eIF5B in the 80S initiation complex. BMC Struct Biol (2014) 0.75
Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation. Nucleic Acids Res (2017) 0.75
Initiation factor 2 stabilizes the ribosome in a semirotated conformation. Proc Natl Acad Sci U S A (2015) 0.75
Locking and unlocking of ribosomal motions. Cell (2003) 6.59
The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site. Cell (2003) 6.01
Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy. Nat Struct Biol (2003) 3.77
The cryo-EM structure of a translation initiation complex from Escherichia coli. Cell (2005) 2.91
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis. Proc Natl Acad Sci U S A (2009) 2.69
Fast evaluation of fluctuations in biochemical networks with the linear noise approximation. Genome Res (2003) 2.63
Structure of the Escherichia coli ribosomal termination complex with release factor 2. Nature (2003) 2.54
Selective charging of tRNA isoacceptors induced by amino-acid starvation. EMBO Rep (2005) 2.48
A cryo-electron microscopic study of ribosome-bound termination factor RF2. Nature (2003) 2.42
Regulatory nascent peptides in the ribosomal tunnel. Cell (2002) 2.41
The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors. EMBO J (2002) 2.37
Peptidyl-tRNA regulates the GTPase activity of translation factors. Cell (2003) 2.25
The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol (2003) 2.23
Termination of translation: interplay of mRNA, rRNAs and release factors? EMBO J (2003) 2.20
Slow peptide bond formation by proline and other N-alkylamino acids in translation. Proc Natl Acad Sci U S A (2008) 2.11
Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3. Mol Cell (2002) 1.98
Near-critical phenomena in intracellular metabolite pools. Biophys J (2003) 1.92
RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors. Cell (2007) 1.89
The kinetics of ribosomal peptidyl transfer revisited. Mol Cell (2008) 1.70
Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G. Mol Cell (2005) 1.69
Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs. J Biol (2005) 1.67
How initiation factors tune the rate of initiation of protein synthesis in bacteria. EMBO J (2006) 1.67
Ribosome rescue by tmRNA requires truncated mRNAs. J Mol Biol (2004) 1.63
Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies. Mol Cell (2005) 1.58
The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis. EMBO J (2003) 1.54
The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure. Mol Cell (2005) 1.53
The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer. FEBS Lett (2005) 1.52
Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset. J Struct Biol (2004) 1.46
Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome. J Cell Biol (2003) 1.45
Genetic code translation displays a linear trade-off between efficiency and accuracy of tRNA selection. Proc Natl Acad Sci U S A (2011) 1.31
The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2. Mol Microbiol (2003) 1.29
Pre-binding of small protein B to a stalled ribosome triggers trans-translation. J Biol Chem (2004) 1.29
Rate and accuracy of bacterial protein synthesis revisited. Curr Opin Microbiol (2008) 1.26
pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA. Proc Natl Acad Sci U S A (2010) 1.23
Over expression of a tRNA(Leu) isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. J Mol Biol (2005) 1.22
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J (2008) 1.21
Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting. EMBO J (2008) 1.17
A time-resolved investigation of ribosomal subunit association. J Mol Biol (2005) 1.16
Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3. Biochimie (2006) 1.14
Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM. J Mol Biol (2006) 1.11
Near-critical behavior of aminoacyl-tRNA pools in E. coli at rate-limiting supply of amino acids. Biophys J (2004) 1.11
The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome. RNA (2007) 1.10
Mapping the interaction of SmpB with ribosomes by footprinting of ribosomal RNA. Nucleic Acids Res (2005) 1.08
Comment on "The mechanism for activation of GTP hydrolysis on the ribosome". Science (2011) 1.07
Kinetics of macrolide action: the josamycin and erythromycin cases. J Biol Chem (2004) 1.06
Cofactor dependent conformational switching of GTPases. Biophys J (2008) 1.04
Increased RNA polymerase availability directs resources towards growth at the expense of maintenance. EMBO J (2009) 1.01
Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits. J Mol Biol (2007) 1.00
Positive allosteric feedback regulation of the stringent response enzyme RelA by its product. EMBO Rep (2012) 0.99
The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form. Proc Natl Acad Sci U S A (2008) 0.98
What makes ribosome-mediated transcriptional attenuation sensitive to amino acid limitation? PLoS Comput Biol (2005) 0.97
Stop codon recognition and interactions with peptide release factor RF3 of truncated and chimeric RF1 and RF2 from Escherichia coli. Mol Microbiol (2003) 0.97
Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences. J Biol Chem (2006) 0.97
Targeting and insertion of heterologous membrane proteins in E. coli. Biochimie (2003) 0.94
The molecular mechanism of peptide-mediated erythromycin resistance. J Biol Chem (2006) 0.92
Bistable bacterial growth rate in response to antibiotics with low membrane permeability. Phys Rev Lett (2006) 0.92
The impact of aminoglycosides on the dynamics of translation elongation. Cell Rep (2013) 0.92
tmRNA.SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes. J Struct Biol (2009) 0.92
Structure probing of tmRNA in distinct stages of trans-translation. RNA (2007) 0.91
tmRNA-induced release of messenger RNA from stalled ribosomes. J Mol Biol (2005) 0.91
Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits. EMBO J (2010) 0.91
Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency. EMBO J (2009) 0.89
Inefficient delivery but fast peptide bond formation of unnatural L-aminoacyl-tRNAs in translation. J Am Chem Soc (2012) 0.87
Simultaneous binding of trigger factor and signal recognition particle to the E. coli ribosome. Biochimie (2004) 0.87
Drug efflux pump deficiency and drug target resistance masking in growing bacteria. Proc Natl Acad Sci U S A (2009) 0.86
The role of ribosomal protein L11 in class I release factor-mediated translation termination and translational accuracy. J Biol Chem (2005) 0.86
Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance. Mol Microbiol (2010) 0.86
A proximal promoter element required for positive transcriptional control by guanosine tetraphosphate and DksA protein during the stringent response. J Biol Chem (2013) 0.84
Optimal control of gene expression for fast proteome adaptation to environmental change. Proc Natl Acad Sci U S A (2013) 0.83
Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1. Elife (2013) 0.82
A new beginning of the end of translation. Nat Struct Biol (2002) 0.81
Ribosomes lacking protein S20 are defective in mRNA binding and subunit association. J Mol Biol (2010) 0.81
A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids. RNA (2014) 0.80
Identification of enzyme inhibitory mechanisms from steady-state kinetics. Biochimie (2011) 0.78
Sensitivity analysis of metabolic cascades catalyzed by bifunctional enzymes. Mol Biol Rep (2002) 0.78
Ribosome bypassing at serine codons as a test of the model of selective transfer RNA charging. EMBO Rep (2005) 0.78
Peptide formation by N-methyl amino acids in translation is hastened by higher pH and tRNA(Pro). ACS Chem Biol (2014) 0.77
Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin. Biochimie (2009) 0.77
Protein synthesis: Translocation in slow motion. Nature (2010) 0.76
Structural and functional prerequisites for ribosomal nascent peptide acceptors: attempts to decipher the nature of the ribosome's catalysis of peptide bond formation. Nucleic Acids Symp Ser (Oxf) (2008) 0.75