Published in Anal Chem on January 15, 2010
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip (2010) 1.97
MHC class II tetramers. J Immunol (2012) 1.45
Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A (2012) 1.41
Imaging immune surveillance of individual natural killer cells confined in microwell arrays. PLoS One (2010) 0.94
New assays for monitoring residual HIV burden in effectively treated individuals. Curr Opin HIV AIDS (2013) 0.93
Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab Chip (2012) 0.89
Peptide-MHC cellular microarray with innovative data analysis system for simultaneously detecting multiple CD4 T-cell responses. PLoS One (2010) 0.83
Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Anal Chem (2012) 0.83
Characterization of cell seeding and specific capture of B cells in microbubble well arrays. Biomed Microdevices (2013) 0.79
Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis. Mult Scler Int (2013) 0.78
Development of Microfluidic Systems Enabling High-Throughput Single-Cell Protein Characterization. Sensors (Basel) (2016) 0.76
Protein Adsorption in Microengraving Immunoassays. Sensors (Basel) (2015) 0.75
Cells on chips. Nature (2006) 8.40
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci U S A (1989) 5.07
T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature (1990) 4.40
MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen. J Clin Invest (1999) 3.83
Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells. J Exp Med (2001) 3.75
T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol (2003) 3.38
A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol (2006) 2.94
Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem (2005) 2.58
Dynamic single-cell analysis for quantitative biology. Anal Chem (2006) 2.36
A rapid and efficient single-cell manipulation method for screening antigen-specific antibody-secreting cells from human peripheral blood. Nat Med (2009) 2.24
Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol (1990) 2.07
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol (2008) 2.03
Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc Natl Acad Sci U S A (1990) 1.93
Screening individual hybridomas by microengraving to discover monoclonal antibodies. Nat Protoc (2009) 1.73
Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab Chip (2008) 1.71
Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc Natl Acad Sci U S A (2000) 1.61
T-cell signalling and autoimmunity: molecular mechanisms of disease. Nat Rev Immunol (2002) 1.56
Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes. Lab Chip (2004) 1.52
Functional avidity directs T-cell fate in autoreactive CD4+ T cells. Blood (2005) 1.39
Detecting cytokine release from single T-cells. Anal Chem (2009) 1.37
T helper cell effector fates--who, how and where? Curr Opin Immunol (2006) 1.26
Profiling antibody responses by multiparametric analysis of primary B cells. Proc Natl Acad Sci U S A (2008) 1.25
Low-avidity recognition by CD4+ T cells directed to self-antigens. Eur J Immunol (2003) 1.21
Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J Immunol (2000) 1.18
Single lymphocyte analysis with a microwell array chip. Cytometry A (2007) 1.12
MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete. Clin Immunol (2004) 1.10
Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med (1997) 1.08
High-density microcavity array for cell detection: single-cell analysis of hematopoietic stem cells in peripheral blood mononuclear cells. Anal Chem (2009) 1.06
Changes in autoreactive T cell avidity during type 1 diabetes development. Clin Immunol (2009) 1.01
Cell-microarray analysis of antigen-specific B-cells: single cell analysis of antigen receptor expression and specificity. Cytometry A (2007) 0.94
Multianalyte single-cell analysis with multiple cell lines using a fiber-optic array. Anal Chem (2007) 0.86
SFMAC: a novel method for analyzing multiple parameters on lymphocytes with a single fluorophore in cell-microarray system. Cytometry A (2009) 0.84
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Femtosecond X-ray protein nanocrystallography. Nature (2011) 14.34
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med (2011) 9.90
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 8.98
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet (2007) 8.74
FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 8.73
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature (2008) 7.00
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol (2003) 6.07
Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med (2011) 5.24
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet (2005) 5.02
Automated high-dimensional flow cytometric data analysis. Proc Natl Acad Sci U S A (2009) 4.91
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A (2004) 4.70
Single mimivirus particles intercepted and imaged with an X-ray laser. Nature (2011) 4.63
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature (2013) 4.57
Induction and molecular signature of pathogenic TH17 cells. Nat Immunol (2012) 4.43
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol (2006) 4.06
Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Nature (2007) 3.92
De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nat Genet (2009) 3.86
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science (2007) 3.70
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature (2005) 3.62
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med (2010) 3.32
IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A (2009) 3.31
Genetics of type 1A diabetes. N Engl J Med (2009) 3.18
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A (2006) 3.13
Human CD4+CD25+ regulatory T cells. Semin Immunol (2004) 3.13
Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain (2009) 3.04
IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood (2009) 3.04
Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol (2009) 2.95
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (2014) 2.77
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med (2007) 2.64
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (2014) 2.63
Apolipoprotein-mediated pathways of lipid antigen presentation. Nature (2005) 2.61
Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol (2002) 2.61
Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells. Clin Immunol (2005) 2.60
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci U S A (2005) 2.57
Human regulatory T cells and their role in autoimmune disease. Immunol Rev (2006) 2.56
A high-density screen for linkage in multiple sclerosis. Am J Hum Genet (2005) 2.50
National Inventory of Landscapes in Sweden (NILS)--scope, design, and experiences from establishing a multiscale biodiversity monitoring system. Environ Monit Assess (2010) 2.48
Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med (2006) 2.43
Multiple sclerosis. J Clin Invest (2012) 2.41
Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol (2009) 2.41
The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A (2009) 2.38
Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes (2010) 2.36
Models from experiments: combinatorial drug perturbations of cancer cells. Mol Syst Biol (2008) 2.33
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A (2009) 2.31
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Prediction and pathogenesis in type 1 diabetes. Immunity (2010) 2.26
Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration. Immunity (2012) 2.18
A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol (2015) 2.16
Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease. Nat Med (2011) 2.14
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity (2013) 2.08
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol (2008) 2.03
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes (2002) 2.01
Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A (2011) 2.00
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol (2009) 2.00
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity (2004) 2.00
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip (2010) 1.97
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest (2002) 1.95
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest (2006) 1.91
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet (2010) 1.89
Fingolimod for multiple sclerosis. N Engl J Med (2012) 1.85
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol (2009) 1.83
Role of "Western diet" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep (2014) 1.79
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol (2004) 1.78
Specific peripheral B cell tolerance defects in patients with multiple sclerosis. J Clin Invest (2013) 1.76
A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest (2011) 1.75
Suppressor T cells in human diseases. J Exp Med (2004) 1.73
Screening individual hybridomas by microengraving to discover monoclonal antibodies. Nat Protoc (2009) 1.73
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J (2009) 1.72
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide. J Exp Med (2006) 1.67
Differential gene expression profiles are dependent upon method of peripheral blood collection and RNA isolation. BMC Genomics (2008) 1.65
Common variants in P2RY11 are associated with narcolepsy. Nat Genet (2010) 1.65
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain (2011) 1.61
Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care (2002) 1.59
TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol (2008) 1.58
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet (2013) 1.55
Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort. Arthritis Rheum (2006) 1.55
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol (2009) 1.55