Published in Cell on July 28, 2006
One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol (2008) 4.54
Protein quality control in the early secretory pathway. EMBO J (2008) 3.59
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19
The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum. Traffic (2008) 3.07
The ubiquitylation machinery of the endoplasmic reticulum. Nature (2009) 2.66
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J Cell Biol (2007) 2.53
Dissecting the ER-associated degradation of a misfolded polytopic membrane protein. Cell (2008) 2.41
SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins. Proc Natl Acad Sci U S A (2008) 2.38
Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell (2011) 2.36
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell (2010) 2.33
Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. Mol Cell (2007) 2.20
Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol (2007) 2.17
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J Cell Biol (2006) 2.13
Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin Cell Dev Biol (2007) 2.13
Inhibition of p97-dependent protein degradation by Eeyarestatin I. J Biol Chem (2008) 2.07
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci (2013) 2.04
Endoplasmic reticulum protein quality control and its relationship to environmental stress responses in plants. Plant Cell (2010) 1.96
Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell (2009) 1.94
Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum. J Cell Biol (2009) 1.93
Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell (2008) 1.86
Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates. J Cell Biol (2010) 1.85
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. J Biol Chem (2008) 1.77
Quality control: ER-associated degradation: protein quality control and beyond. J Cell Biol (2014) 1.75
The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation). Biochem J (2007) 1.74
Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems. Curr Opin Cell Biol (2011) 1.74
The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73
EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Mol Cell (2009) 1.56
Derlin-1 facilitates the retro-translocation of cholera toxin. Mol Biol Cell (2007) 1.55
The mammalian endoplasmic reticulum-associated degradation system. Cold Spring Harb Perspect Biol (2013) 1.50
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Mol Biol Cell (2007) 1.49
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. J Biol Chem (2009) 1.47
ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell (2008) 1.44
Quality and quantity control at the endoplasmic reticulum. Curr Opin Cell Biol (2010) 1.42
A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics (2009) 1.42
Substrate-specific mediators of ER associated degradation (ERAD). Curr Opin Cell Biol (2009) 1.40
A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. J Biol Chem (2008) 1.38
Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD. J Cell Biol (2007) 1.37
Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell (2014) 1.35
Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel) (2010) 1.34
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. Mol Biol Cell (2007) 1.33
Protein folding and quality control in the ER. Cold Spring Harb Perspect Biol (2011) 1.33
In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. J Biol Chem (2009) 1.31
Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. J Biol Chem (2008) 1.29
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit Rev Biochem Mol Biol (2010) 1.29
A nucleus-based quality control mechanism for cytosolic proteins. Mol Biol Cell (2010) 1.28
Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation. Diabetes Obes Metab (2010) 1.23
Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.22
Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest (2010) 1.19
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem (2011) 1.17
The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell (2010) 1.17
Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY. J Biol Chem (2008) 1.16
Exposed hydrophobicity is a key determinant of nuclear quality control degradation. Mol Biol Cell (2011) 1.16
SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. J Biol Chem (2011) 1.16
Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Proc Natl Acad Sci U S A (2009) 1.15
Endoplasmic reticulum-associated degradation of glycoproteins in plants. Front Plant Sci (2012) 1.11
Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol Cell (2011) 1.11
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep (2008) 1.11
Secretory protein biogenesis and traffic in the early secretory pathway. Genetics (2013) 1.11
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. J Biol Chem (2011) 1.10
Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis. Trends Biochem Sci (2012) 1.09
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Cell Rep (2012) 1.09
Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. J Biol Chem (2009) 1.08
A luminal flavoprotein in endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A (2009) 1.08
Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum. Mol Biol Cell (2010) 1.07
Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem (2011) 1.07
Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J (2009) 1.07
Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A (2014) 1.06
Have you HRD? Understanding ERAD is DOAble! Cell (2006) 1.06
Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system. Mol Biol Cell (2009) 1.05
RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin. Mol Biol Cell (2010) 1.05
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J Biol Chem (2011) 1.04
Glycosylation-directed quality control of protein folding. Nat Rev Mol Cell Biol (2015) 1.04
Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell (2012) 1.03
Modularity of the Hrd1 ERAD complex underlies its diverse client range. J Cell Biol (2010) 1.02
Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope. Mol Biol Cell (2011) 1.01
Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. J Biol Chem (2010) 0.99
Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality control. Mol Biol Cell (2010) 0.97
Ricin trafficking in plant and mammalian cells. Toxins (Basel) (2011) 0.97
Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation. J Exp Med (2014) 0.96
How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD. Biochim Biophys Acta (2013) 0.96
Signaling pathways from the endoplasmic reticulum and their roles in disease. Genes (Basel) (2013) 0.96
Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase. J Biol Chem (2013) 0.96
Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. Cell (2016) 0.94
The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells. J Biol Chem (2008) 0.93
Yos9p assists in the degradation of certain nonglycosylated proteins from the endoplasmic reticulum. Mol Biol Cell (2011) 0.93
Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo. J Biol Chem (2009) 0.93
The Arabidopsis homolog of the mammalian OS-9 protein plays a key role in the endoplasmic reticulum-associated degradation of misfolded receptor-like kinases. Mol Plant (2012) 0.93
Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation. Mol Biol Cell (2013) 0.92
ERAD and how viruses exploit it. Front Microbiol (2014) 0.91
Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell (2011) 0.91
Sorting things out through endoplasmic reticulum quality control. Mol Membr Biol (2010) 0.91
Endoplasmic reticulum-mediated protein quality control in Arabidopsis. Front Plant Sci (2014) 0.91
A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem (2010) 0.90
Live cell imaging of protein dislocation from the endoplasmic reticulum. J Biol Chem (2012) 0.90
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife (2016) 0.89
The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem (2013) 0.89
Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking. FEBS Lett (2011) 0.88
Global analysis of protein expression in yeast. Nature (2003) 34.15
Global analysis of protein localization in budding yeast. Nature (2003) 33.22
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science (2009) 20.75
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature (2006) 12.92
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell (2011) 10.56
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics (2007) 7.93
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science (2006) 6.75
Conformational variations in an infectious protein determine prion strain differences. Nature (2004) 6.15
An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (2009) 6.14
Nascent transcript sequencing visualizes transcription at nucleotide resolution. Nature (2011) 5.95
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol (2004) 4.96
The physical basis of how prion conformations determine strain phenotypes. Nature (2006) 4.77
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science (2009) 4.58
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol (2006) 4.49
The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc (2012) 4.41
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Nature (2012) 4.27
A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods (2008) 3.79
Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol (2004) 3.75
Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell (2013) 3.69
High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science (2011) 3.53
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell (2008) 3.51
Proto-genes and de novo gene birth. Nature (2012) 3.43
Emerging principles of conformation-based prion inheritance. Annu Rev Biochem (2004) 3.36
The structural basis of yeast prion strain variants. Nature (2007) 3.31
Orm family proteins mediate sphingolipid homeostasis. Nature (2010) 3.29
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell (2012) 3.27
High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Nat Methods (2007) 3.24
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19
High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods (2008) 3.17
Functional organization of the S. cerevisiae phosphorylation network. Cell (2009) 3.15
Decoding human cytomegalovirus. Science (2012) 2.98
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell (2008) 2.96
A molecular caliper mechanism for determining very long-chain fatty acid length. Cell (2007) 2.76
Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell (2011) 2.55
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol Cell (2002) 2.38
Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol Cell (2005) 2.38
Dissection and design of yeast prions. PLoS Biol (2004) 2.19
Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell (2012) 2.16
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol (2011) 2.15
CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc (2013) 2.05
Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell (2005) 2.01
Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods (2009) 1.98
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell (2008) 1.86
In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104. Mol Cell (2008) 1.81
Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2011) 1.79
Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Elife (2013) 1.77
Directed evolution of substrate-optimized GroEL/S chaperonins. Cell (2002) 1.71
Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol (2007) 1.67
Amyloid structure: conformational diversity and consequences. Annu Rev Biochem (2011) 1.57
Origins and kinetic consequences of diversity in Sup35 yeast prion fibers. Nat Struct Biol (2002) 1.54
Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell (2010) 1.52
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature (2011) 1.49
Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell (2007) 1.41
Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell (2012) 1.40
Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol (2010) 1.37
Generation of prion transmission barriers by mutational control of amyloid conformations. Nature (2003) 1.36
Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains. Comp Funct Genomics (2005) 1.35
Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol (2014) 1.34
An efficient protein transformation protocol for introducing prions into yeast. Methods Enzymol (2006) 1.32
CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A (2007) 1.30
Genome-wide annotation and quantitation of translation by ribosome profiling. Curr Protoc Mol Biol (2013) 1.30
Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.26
Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. J Biol Chem (2005) 1.23
Global cellular response to chemotherapy-induced apoptosis. Elife (2013) 1.19
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol (2013) 1.17
Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell (2013) 1.16
Differences in prion strain conformations result from non-native interactions in a nucleus. Nat Chem Biol (2010) 1.08
From information to knowledge: new technologies for defining gene function. Nat Methods (2009) 1.06
rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments. Bioinformatics (2013) 1.04
Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol (2013) 1.04
Msn2 coordinates a stoichiometric gene expression program. Curr Biol (2013) 0.97
The utility of prions. Dev Cell (2002) 0.96
Systems biology: Reverse engineering the cell. Nature (2008) 0.95
A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev (2013) 0.94
Native elongating transcript sequencing (NET-seq). Curr Protoc Mol Biol (2012) 0.94
Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes. Nat Protoc (2013) 0.93
Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci U S A (2007) 0.92
Strain conformation, primary structure and the propagation of the yeast prion [PSI+]. Nat Struct Mol Biol (2011) 0.91
Systems biology: many things from one. Nature (2006) 0.91
J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem (2010) 0.90
Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts. Eukaryot Cell (2010) 0.89
The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum. Cold Spring Harb Perspect Biol (2013) 0.84
Genetics: Noise rules. Nature (2011) 0.80
Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion. J Mol Biol (2011) 0.78
Special issue: the molecular and cellular mechanisms of amyloidosis. J Mol Biol (2012) 0.76