Published in Cell on November 04, 2005
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell (2005) 7.20
An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (2009) 6.14
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Functional organization of the S. cerevisiae phosphorylation network. Cell (2009) 3.15
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase. Science (2008) 3.09
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet (2009) 3.06
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Trait variation in yeast is defined by population history. PLoS Genet (2011) 2.50
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nat Biotechnol (2009) 2.49
Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput Biol (2008) 2.46
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Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science (2012) 1.87
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Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Mol Syst Biol (2007) 1.79
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Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. Genome Biol (2007) 1.73
Computer-aided design of functional protein interactions. Nat Chem Biol (2009) 1.73
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. Nat Biotechnol (2017) 1.72
Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. Science (2011) 1.68
Quantitative genetic-interaction mapping in mammalian cells. Nat Methods (2013) 1.68
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A fine scale phenotype-genotype virulence map of a bacterial pathogen. Genome Res (2012) 1.67
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An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet (2011) 1.62
Finding friends and enemies in an enemies-only network: a graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions. Genome Res (2008) 1.61
Predicting genetic modifier loci using functional gene networks. Genome Res (2010) 1.59
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The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages. BMC Genomics (2008) 1.56
The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proc Natl Acad Sci U S A (2008) 1.54
A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol (2009) 1.54
Inheritance of cortical ER in yeast is required for normal septin organization. J Cell Biol (2007) 1.51
Structural characterization of the Get4/Get5 complex and its interaction with Get3. Proc Natl Acad Sci U S A (2010) 1.49
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. J Biol Chem (2008) 1.44
Subcellular Partitioning of Protein Tyrosine Phosphatase 1B to the Endoplasmic Reticulum and Mitochondria Depends Sensitively on the Composition of Its Tail Anchor. PLoS One (2015) 1.44
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol (2010) 1.44
JColorGrid: software for the visualization of biological measurements. BMC Bioinformatics (2006) 1.43
Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products. Proc Natl Acad Sci U S A (2013) 1.42
Maximal extraction of biological information from genetic interaction data. PLoS Comput Biol (2009) 1.42
A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics (2009) 1.42
The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic. J Cell Biol (2007) 1.42
DRYGIN: a database of quantitative genetic interaction networks in yeast. Nucleic Acids Res (2009) 1.41
Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol (2008) 1.41
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Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell (2012) 1.40
The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. Genetics (2006) 1.38
Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol (2010) 1.37
Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog (2007) 1.37
A single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast. Mol Cell (2008) 1.36
Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. PLoS One (2010) 1.36
From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions. Mol Syst Biol (2008) 1.35
Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol (2008) 1.35
Quantitative genetic interaction mapping using the E-MAP approach. Methods Enzymol (2010) 1.35
FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. PLoS One (2010) 1.34
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev (2009) 1.34
Global analysis of protein expression in yeast. Nature (2003) 34.15
Global analysis of protein localization in budding yeast. Nature (2003) 33.22
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 22.04
Global mapping of the yeast genetic interaction network. Science (2004) 21.34
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science (2009) 20.75
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Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature (2006) 12.92
A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 12.07
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell (2011) 10.56
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics (2007) 7.93
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Science (2001) 7.08
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science (2006) 6.75
An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Conformational variations in an infectious protein determine prion strain differences. Nature (2004) 6.15
An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (2009) 6.14
Nascent transcript sequencing visualizes transcription at nucleotide resolution. Nature (2011) 5.95
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Role of formins in actin assembly: nucleation and barbed-end association. Science (2002) 5.47
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol (2004) 4.96
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
The physical basis of how prion conformations determine strain phenotypes. Nature (2006) 4.77
Similarities and differences in genome-wide expression data of six organisms. PLoS Biol (2003) 4.75
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature (2004) 4.65
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science (2009) 4.58
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell (2003) 4.49
A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol (2006) 4.49
Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol (2006) 4.45
The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc (2012) 4.41
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science (2008) 4.36
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature (2005) 4.33
The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Nature (2012) 4.27
Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24
Expression Profiler: next generation--an online platform for analysis of microarray data. Nucleic Acids Res (2004) 4.21
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell (2004) 4.20
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell (2006) 4.08
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell (2004) 4.04
A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell (2003) 4.04
Rewiring of genetic networks in response to DNA damage. Science (2010) 4.03
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods (2008) 3.79
Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol (2004) 3.75
Differential network biology. Mol Syst Biol (2012) 3.74
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell (2013) 3.69
High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science (2011) 3.53
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell (2008) 3.51