Published in Curr Protoc Mol Biol on July 01, 2013
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Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell (2005) 10.41
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
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Conformational variations in an infectious protein determine prion strain differences. Nature (2004) 6.15
An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science (2009) 6.14
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The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
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The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria. Nature (2012) 4.27
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell (2006) 4.08
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Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol (2004) 3.75
Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell (2013) 3.69
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A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell (2008) 3.51
Proto-genes and de novo gene birth. Nature (2012) 3.43
Emerging principles of conformation-based prion inheritance. Annu Rev Biochem (2004) 3.36
The structural basis of yeast prion strain variants. Nature (2007) 3.31
Orm family proteins mediate sphingolipid homeostasis. Nature (2010) 3.29
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell (2012) 3.27
High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Nat Methods (2007) 3.24
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19
High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods (2008) 3.17
Functional organization of the S. cerevisiae phosphorylation network. Cell (2009) 3.15
Decoding human cytomegalovirus. Science (2012) 2.98
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell (2008) 2.96
A molecular caliper mechanism for determining very long-chain fatty acid length. Cell (2007) 2.76
Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo. Cell (2011) 2.55
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol Cell (2002) 2.38
Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol Cell (2005) 2.38
Dissection and design of yeast prions. PLoS Biol (2004) 2.19
Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell (2012) 2.16
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol (2011) 2.15
CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc (2013) 2.05
Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins. Cell (2005) 2.01
Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods (2009) 1.98
A general lack of compensation for gene dosage in yeast. Mol Syst Biol (2010) 1.96
Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell (2008) 1.86
In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104. Mol Cell (2008) 1.81
Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2011) 1.79
Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Elife (2013) 1.77
Directed evolution of substrate-optimized GroEL/S chaperonins. Cell (2002) 1.71
The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Cell (2005) 1.68
Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol (2007) 1.67
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Membranes in balance: mechanisms of sphingolipid homeostasis. Mol Cell (2010) 1.52
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Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell (2007) 1.41
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Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains. Comp Funct Genomics (2005) 1.35
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An efficient protein transformation protocol for introducing prions into yeast. Methods Enzymol (2006) 1.32
CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A (2007) 1.30
Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.26
Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. J Biol Chem (2005) 1.23
Global cellular response to chemotherapy-induced apoptosis. Elife (2013) 1.19
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol (2013) 1.17
Aneuploid yeast strains exhibit defects in cell growth and passage through START. Mol Biol Cell (2013) 1.16
Differences in prion strain conformations result from non-native interactions in a nucleus. Nat Chem Biol (2010) 1.08
Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions. Elife (2012) 1.08
From information to knowledge: new technologies for defining gene function. Nat Methods (2009) 1.06
rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments. Bioinformatics (2013) 1.04
Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Genome Biol (2013) 1.04
The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing. Proc Natl Acad Sci U S A (2008) 1.00
Msn2 coordinates a stoichiometric gene expression program. Curr Biol (2013) 0.97
The utility of prions. Dev Cell (2002) 0.96
Systems biology: Reverse engineering the cell. Nature (2008) 0.95
A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev (2013) 0.94
Native elongating transcript sequencing (NET-seq). Curr Protoc Mol Biol (2012) 0.94
Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes. Nat Protoc (2013) 0.93