Published in J Mol Biol on March 14, 2003
Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74
Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci (2010) 3.61
Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab (2009) 2.81
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A (2007) 2.65
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta (2007) 1.89
Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem (2008) 1.62
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (2007) 1.61
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27
Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome. Proc Natl Acad Sci U S A (2008) 1.23
Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem (2009) 1.21
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci (2005) 1.11
A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry (2009) 1.10
Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure (2011) 1.01
Phosphorylation releases constraints to domain motion in ERK2. Proc Natl Acad Sci U S A (2014) 1.00
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase. J Biol Chem (2011) 0.99
Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol (2012) 0.98
Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem (2011) 0.96
Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci (2015) 0.96
Electronic measurements of single-molecule catalysis by cAMP-dependent protein kinase A. J Am Chem Soc (2013) 0.95
Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform. Biochim Biophys Acta (2007) 0.91
An enriched structural kinase database to enable kinome-wide structure-based analyses and drug discovery. Protein Sci (2010) 0.88
Identifying human kinase-specific protein phosphorylation sites by integrating heterogeneous information from various sources. PLoS One (2010) 0.87
Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One (2009) 0.86
Role of conformational entropy in the activity and regulation of the catalytic subunit of protein kinase A. FEBS J (2013) 0.85
Molecular features of product release for the PKA catalytic cycle. Biochemistry (2014) 0.84
Design principles underpinning the regulatory diversity of protein kinases. Philos Trans R Soc Lond B Biol Sci (2012) 0.83
The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget (2013) 0.82
Extracellular-regulated kinase 2 is activated by the enhancement of hinge flexibility. J Mol Biol (2014) 0.82
Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J Biol Chem (2015) 0.81
Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry (2013) 0.81
Correlated mutation analysis on the catalytic domains of serine/threonine protein kinases. PLoS One (2009) 0.81
Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. J Biol Chem (2015) 0.80
Calculating pKa values in the cAMP-dependent protein kinase: the effect of conformational change and ligand binding. Protein Sci (2010) 0.78
Demonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activity. J Biol Chem (2012) 0.77
Multiple steps to activate FAK's kinase domain: adaptation to confined environments? Biophys J (2013) 0.75
cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry. Biochem J (2016) 0.75
Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysis. PLoS One (2010) 0.75
Binding mechanism and dynamic conformational change of C subunit of PKA with different pathways. Proc Natl Acad Sci U S A (2017) 0.75
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature (2012) 10.17
Epidermal electronics. Science (2011) 8.65
Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Detection and quantification of rare mutations with massively parallel sequencing. Proc Natl Acad Sci U S A (2011) 6.29
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol (2011) 6.18
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature (2010) 4.53
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A (2006) 4.09
Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74
PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat Immunol (2004) 3.39
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet (2012) 3.38
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science (2005) 3.28
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell (2007) 3.19
Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nat Neurosci (2011) 3.03
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology (2012) 2.74
A transient interaction between two phosphorelay proteins trapped in a crystal lattice reveals the mechanism of molecular recognition and phosphotransfer in signal transduction. Structure (2000) 2.71
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A (2007) 2.65
BRAD, the genetics and genomics database for Brassica plants. BMC Plant Biol (2011) 2.59
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators. Proc Natl Acad Sci U S A (2006) 2.58
Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med (2013) 2.58
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature (2005) 2.54
A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51
Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy. Nat Mater (2011) 2.51
Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation (2008) 2.48
IgH gene rearrangements as plasma biomarkers in Non- Hodgkin's lymphoma patients. Oncotarget (2011) 2.34
The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A (2004) 2.32
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
Dynamics of signaling by PKA. Biochim Biophys Acta (2005) 2.26
Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis. J Am Soc Mass Spectrom (2006) 2.25
Printed assemblies of inorganic light-emitting diodes for deformable and semitransparent displays. Science (2009) 2.08
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol (2002) 2.07
Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet (2003) 2.01
Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A (2008) 1.99
Arrays of sealed silicon nanotubes as anodes for lithium ion batteries. Nano Lett (2010) 1.98
Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem (2010) 1.91
Deciphering the diploid ancestral genome of the Mesohexaploid Brassica rapa. Plant Cell (2013) 1.90
Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice. Liver Transpl (2006) 1.90
Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology (2009) 1.89
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta (2007) 1.89
cAMP activation of PKA defines an ancient signaling mechanism. Proc Natl Acad Sci U S A (2006) 1.79
Initial evaluation of a direct detection device detector for single particle cryo-electron microscopy. J Struct Biol (2011) 1.77
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer (2006) 1.76
Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta (2009) 1.76
Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments. Protein Sci (2006) 1.75
Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol (2013) 1.75
Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology (2003) 1.74
MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins. Cancer Lett (2012) 1.73
Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology (2006) 1.71
Applications of direct detection device in transmission electron microscopy. J Struct Biol (2007) 1.70
Genetic relationships within Brassica rapa as inferred from AFLP fingerprints. Theor Appl Genet (2005) 1.66
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65
Four-color DNA sequencing with 3'-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides. Proc Natl Acad Sci U S A (2008) 1.64
Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol (2009) 1.63
Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (2007) 1.61
Allosteric activation of functionally asymmetric RAF kinase dimers. Cell (2013) 1.60
Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. Structure (2001) 1.59
Stretchable GaAs photovoltaics with designs that enable high areal coverage. Adv Mater (2011) 1.56
Mutant proteins as cancer-specific biomarkers. Proc Natl Acad Sci U S A (2011) 1.56
Hybridization array technology coupled with chemostat culture: Tools to interrogate gene expression in Saccharomyces cerevisiae. Methods (2002) 1.56
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
A primary atypical solitary fibrous tumor of the sella mimicking nonfunctional pituitary adenoma: a case report. Acta Neurochir (Wien) (2009) 1.53
Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cancer Lett (2010) 1.51
Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase. Mol Cell (1998) 1.51
Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol (2004) 1.51
Active pixel sensor array as a detector for electron microscopy. Ultramicroscopy (2005) 1.49
Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology (2009) 1.48
Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials (2008) 1.48
Biased gene fractionation and dominant gene expression among the subgenomes of Brassica rapa. PLoS One (2012) 1.47
Effect of an acute mechanical stimulus on aortic structure in the transverse aortic constriction mouse model. Clin Exp Pharmacol Physiol (2011) 1.47
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins (2002) 1.45
Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S ribosomal DNA (rDNA) quantification and correlations with immune activation. J Acquir Immune Defic Syndr (2011) 1.45
Evolution of allostery in the cyclic nucleotide binding module. Genome Biol (2007) 1.44
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A (2011) 1.44
A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A (2005) 1.43
A novel model for evaluating the risk of hepatitis B recurrence after liver transplantation. Liver Int (2011) 1.43
Intravenous thrombolysis for minor stroke and rapidly improving symptoms: a quantitative overview. Neurol Sci (2014) 1.42
SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways. Atherosclerosis (2012) 1.41
Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species. J Biol Chem (2008) 1.41
MADMAX - Management and analysis database for multiple ~omics experiments. J Integr Bioinform (2011) 1.40
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev (2013) 1.40
Optimized structural designs for stretchable silicon integrated circuits. Small (2009) 1.40
Microstructured elastomeric surfaces with reversible adhesion and examples of their use in deterministic assembly by transfer printing. Proc Natl Acad Sci U S A (2010) 1.39
Disruption of apyrases inhibits pollen germination in Arabidopsis. Plant Physiol (2003) 1.38
Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol (2002) 1.38