Published in J Cell Sci on August 14, 2007
Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci (2008) 3.04
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood (2011) 1.79
Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br J Cancer (2008) 1.75
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. J Cell Biol (2008) 1.73
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proc Natl Acad Sci U S A (2009) 1.46
Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell (2008) 1.27
Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion. J Biol Chem (2009) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene (2011) 1.17
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol (2014) 1.15
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07
Arp2/3 complex activity in filopodia of spreading cells. BMC Cell Biol (2008) 1.05
Ezrin promotes invasion and metastasis of pancreatic cancer cells. J Transl Med (2010) 1.05
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells. J Clin Invest (2013) 1.04
Quantification of local morphodynamics and local GTPase activity by edge evolution tracking. PLoS Comput Biol (2008) 1.01
Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. Biochem J (2008) 0.99
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration. Nat Commun (2015) 0.98
Gq-coupled purinergic receptors inhibit insulin-like growth factor-I/phosphoinositide 3-kinase pathway-dependent keratinocyte migration. Mol Biol Cell (2010) 0.88
SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling. Cell Res (2017) 0.81
The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility. Exp Cell Res (2013) 0.80
Overexpression of Isoforms of Nitric Oxide Synthase 1 Adaptor Protein, Encoded by a Risk Gene for Schizophrenia, Alters Actin Dynamics and Synaptic Function. Front Cell Neurosci (2016) 0.76
A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration. Nat Commun (2015) 0.76
Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa. Biol Open (2013) 0.75
Mimicking transient activation of protein kinases in living cells. Proc Natl Acad Sci U S A (2016) 0.75
Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity. Oncogene (2014) 0.75
Regulation of cell migration via the EGFR signaling pathway in oral squamous cell carcinoma cells. Oncol Lett (2016) 0.75
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36
Rho and Rac take center stage. Cell (2004) 10.64
Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature (1994) 10.34
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell (1997) 6.55
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A (1999) 5.62
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol (2003) 5.55
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12
Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Mol Cell Biol (1998) 5.01
Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science (1986) 4.99
Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol (2002) 4.91
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature (2001) 4.83
Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci (1997) 4.52
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol (1995) 4.52
WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J (1998) 4.46
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res (2002) 3.95
A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature (1996) 3.79
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell (2000) 3.68
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature (2000) 3.56
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat Cell Biol (2007) 3.52
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem (1994) 3.37
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol (2006) 3.12
EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells. J Cell Sci (1998) 3.12
Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr Biol (2002) 3.06
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol (2000) 3.04
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J Cell Biol (2002) 2.99
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene (1997) 2.99
Chemotaxis in the absence of PIP3 gradients. Curr Biol (2007) 2.73
Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion. J Cell Biol (2000) 2.56
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A (2004) 2.25
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19
EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism. Clin Exp Metastasis (1996) 2.16
Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. J Cell Biol (1999) 2.14
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. J Cell Sci (2002) 2.11
Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol (2001) 2.11
Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett (2003) 2.11
How is actin polymerization nucleated in vivo? Trends Cell Biol (2001) 2.09
The activation of phosphatidylinositol 3-kinase by Ras. Curr Biol (1994) 2.05
Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism. Cancer Res (1999) 1.98
Integration of signals to the Arp2/3 complex. Curr Opin Cell Biol (2003) 1.95
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol (2004) 1.92
Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension. J Cell Sci (2004) 1.89
Dictyostelium RasG is required for normal motility and cytokinesis, but not growth. J Cell Biol (1997) 1.86
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene (2005) 1.86
The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr Biol (1996) 1.86
RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J Cell Biol (2000) 1.85
Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation. Curr Biol (2000) 1.83
A chemical compass. Nature (2002) 1.83
Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem J (1996) 1.78
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci (2006) 1.70
Regulation of actin dynamics by WASP family proteins. J Biochem (2003) 1.63
Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep (2004) 1.63
The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension. Curr Biol (2001) 1.62
Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism. Proc Natl Acad Sci U S A (1993) 1.62
Coupling membrane protrusion and cell adhesion. J Cell Sci (2003) 1.61
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. J Biol Chem (2000) 1.56
Regulation of WASP/WAVE proteins: making a long story short. J Cell Biol (2004) 1.50
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med (2001) 1.46
Rab5 induces Rac-independent lamellipodia formation and cell migration. Mol Biol Cell (1999) 1.28
Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells. J Biol Chem (2000) 1.28
The chemotactic response to PDGF-BB: evidence of a role for Ras. J Cell Biol (1995) 1.20
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07
Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms. J Biol Chem (2006) 0.98
MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. Proc Natl Acad Sci U S A (1999) 0.93
Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells. J Cell Physiol Suppl (1987) 0.87
Microinjection of Rho and Rac into quiescent Swiss 3T3 cells. Methods Enzymol (1995) 0.86
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 6.60
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem (2005) 5.22
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science (2007) 5.19
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol (2005) 4.75
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res (2004) 4.04
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell (2007) 3.97
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res (2002) 3.95
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol (2006) 3.55
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol (2008) 3.37
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. J Cell Biol (2006) 2.59
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol (2007) 2.48
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res (2009) 2.41
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Sci Transl Med (2013) 2.37
Cell migration and invasion assays. Methods (2005) 2.32
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res (2009) 2.25
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res (2007) 2.24
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal (2008) 2.19
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol (2005) 2.04
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci (2011) 2.00
Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol (2013) 1.95
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene (2005) 1.86
Inhibition of autophagy in mitotic animal cells. Traffic (2002) 1.81
The late endosome is essential for mTORC1 signaling. Mol Biol Cell (2010) 1.79
GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer Res (2002) 1.77
Role of Rho family GTPases in epithelial morphogenesis. Genes Dev (2002) 1.75
Regulation of microtubule stability and mitotic progression by survivin. Cancer Res (2002) 1.74
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. J Cell Biol (2008) 1.73
Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell (2003) 1.71
A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nat Methods (2011) 1.69
Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res (2006) 1.66
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer Res (2007) 1.65
Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol (2009) 1.64
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis (2008) 1.64
Role of synaptojanin 2 in glioma cell migration and invasion. Cancer Res (2004) 1.64
hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. Biochem J (2009) 1.61
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol (2008) 1.57
Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit. J Biol Chem (2005) 1.57
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. J Cell Sci (2006) 1.55
Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Mol Cell (2006) 1.55
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskeleton (2009) 1.54
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest (2008) 1.53
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol Biol Cell (2008) 1.48
Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proc Natl Acad Sci U S A (2009) 1.46
Membrane lipid organization is critical for human neutrophil polarization. J Biol Chem (2003) 1.46
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res (2009) 1.45
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.43
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Sci Signal (2012) 1.38
A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. J Biol Chem (2004) 1.37
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic (2002) 1.35
Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res (2011) 1.33
Mechanisms and cellular roles of local protein synthesis in mammalian cells. Curr Opin Cell Biol (2008) 1.31
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. J Cell Biol (2011) 1.31
Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy. Cancer Res (2004) 1.31
Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic (2007) 1.29
β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. Mol Biol Cell (2013) 1.29
Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res Treat (2004) 1.28
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res (2010) 1.24
Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis. Curr Biol (2003) 1.23
A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2010) 1.23
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis (2011) 1.23
Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1. J Biol Chem (2005) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22